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| 1 | Analysis of the postoperative hemostatic profile of colorectal cancer patients subjected to liver metastasis resection surgery显示文摘BACKGROUND Liver resection surgery has advanced greatly in recent years,and the adoption of fasttrack programs has yielded good results.Combination anesthesia (general anesthesia associated to epidural analgesia) is an anesthetic-analgesic strategy commonly used for the perioperative management of patients undergoing surgery of this kind,though there is controversy regarding the coagulation alterations it may cause and which can favor the development of spinal hematomas.AIM To study the postoperative course of liver resection surgery,an analysis was made of the outcomes of liver resection surgery due to colorectal cancer metastases in our centre in terms of morbiditymortality and hospital stay according to the anesthetic technique used (general vs combination anesthesia).METHODS A prospective study was made of 61 colorectal cancer patients undergoing surgery due to liver metastases under general and combination anesthesia between January 2014 and October 2015.The patient characteristics,intraoperative variables,postoperative complications,evolution of hemostatic parameters,and stay in intensive care and in hospital were analyzed.RESULTS A total of 61 patients were included in two homogeneous groups: general anesthesia (n = 30) and combination anesthesia (general anesthesia associated to epidural analgesia)(n = 31).All patients had normal coagulation values before surgery.The international normalized ratio (INR) in both the general and combination anesthesia groups reached maximum values at 2448 h (mean 1.37 and 1.45 vs 1.39 and 1.41,respectively),followed by a gradual decrease.There was less intraoperative bleeding in the combination anesthesia group (769 mL) than in the general anesthesia group (1200 mL)(P < 0.05).Of the 61 patients,38.8% in the general anesthesia group experienced some respiratory complication vs 6.6% in the combination anesthesia group (P < 0.001).The time to gastrointestinal tolerance was significantly correlated to the type of anesthesia,though not so the stay in critical care or the time to hospital discharge.CONCLUSION Epidural analgesia in liver resection surgery was seen to be safe,with good results in terms of pain control and respiratory complications,and with no associated increase in complications secondary to altered hemostasis. | Guillermo Perez Navarro Ana Maria Pascual Bellosta Sonia María Ortega Lucea Mario Serradilla Martín Jose Manuel Ramirez Rodriguez Javier Martinez Ubieto | 2019 | World Journal of Clinical Cases2019，7，17： | 4 |
| 2 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 3 | Molecular approaches for spinal cord injury treatment显示文摘Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic injuries.Despite decades of research,there is still no efficient treatment for spinal cord injury.Many strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord injury.Among these,molecular compounds are currently being used for neurological recovery,with promising results.These molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost connections.In this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and purines.The mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans. | Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez | 2023 | Neural Regeneration Research2023，18，1： | 3 |
| 4 | 富含组织细胞型横纹肌母细胞肿瘤:一种组织学独特的横纹肌母细胞肿瘤显示文摘许多软组织肿瘤不能简单地划分为“良性”或“恶性”。WHO软组织和骨肿瘤分类将几种类型的软组织肿瘤(如脂肪细胞肿瘤中的非典型脂肪瘤性肿瘤和内皮细胞肿瘤中的血管内皮瘤)确定为中间型(交界型)。一些软组织肿瘤(如韧带样型纤维瘤病和含铁血黄素沉着性纤维脂肪瘤性肿瘤)被认为是中度恶性肿瘤,这可能是因为它们具有局部侵袭性生长的能力,也可能因为它们(如血管瘤样纤维组织细胞瘤和骨化性纤维黏液样肿瘤)具有较低但无法预测的远处转移风险。血管球肿瘤和PEComa等肿瘤的分类系统不仅可以预测临床良、恶性肿瘤具有合理的敏感性和特异性,而且还可以将这些肿瘤的少部分划分为恶性潜能不确定型。有选择的软组织肿瘤(如胃肠道间质肿瘤和孤立性纤维性肿瘤),应从风险评估的角度来看待,而非良、恶性。显示骨骼肌分化的肿瘤传统上一分为二为良性横纹肌瘤或完全恶性横纹肌肉瘤(RMS)。 | Martinez A P Fritchie K J Weiss S W 张仁亚 | 2019 | 临床与实验病理学杂志2019，35，11： | 3 |
| 5 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 6 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 7 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 8 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 9 | Factors regulating spatial distribution of soil water content in small semiarid catchments显示文摘 | Gomez P A Martinez M M Albaladejo J | 2000 | Journal of Hydrology2000，253，： | 1 |
| 10 | Distinct Regulation of pH in and in human melanoma ceils with different metastatic potential 显示文摘 | Martinez-Zaguilan R Martinez GM Gomez A | 1998 | Journal of Cellular Physiology1998，176，1： | 1 |
| 11 | Lightning performance analysis of overhead transmission lines using the EMTP显示文摘 | Martinez J A Castro-Aranda F | 2005 | IEEE Trans on Power Delivery2005，20，3： | 1 |
| 12 | Facilitated sprouting in a peripheral nerve injury显示文摘 | Xu Q G Midha R Martinez J A | 2008 | Neuroscience2008，152，： | 1 |
| 13 | Venous thromboembolie disease in general surgery显示文摘 | Areelus Martinez A JI | 2008 | Med Clin (Barc)2008，131，2： | 1 |
| 14 | Food-web structure and network theory:The role of connectance and size显示文摘 | Dunne J A Williams R J Martinez N D | 2002 | Proceedings of the National Academy of Sciences2002，99，12： | 1 |
| 15 | A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint 显示文摘 | Pena E Calvo B Martinez M A | 2006 | Journal of Biomechanics2006，39，9： | 1 |
| 16 | A rapid,sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry显示文摘 | YOUNG C L ASH D DRISKELL W J BOYER A E MARTINEZ R A SILKS L A BARR J R | 2004 | Anal Toxicol2004，28，5： | 1 |
| 17 | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum loeosporioides, causal agent of anthracnose disease in tropical fruits 显示文摘 | Almada Ruiz E Martinez Tellez M A Hem ndez Alamos M M | 2003 | Pest Manag Sci2003，59，： | 1 |
| 18 | Evaluation of longitudinal ventricular function with tissue Doppler echocardiography in children treated with an- thracyclines显示文摘 | Stapleton GE Stapleton SL Martinez A Ayres NA Kovalchin JP Bezold LI | 2007 | J Am Soc Echocardiogr2007，20，5： | 1 |
| 19 | Thermal cracking of coal residues: Kinetics of asphaltene decomposition显示文摘 | MARTINEZ M T BENITO A M CALLEJAS M A | 1997 | Fuel1997，76，9： | 1 |
| 20 | Introduction of a product family penalty function using physical programming显示文摘 | Messac A Martinez M P Simpson T W | 2002 | Transactions of ASME2002，124，2： | 1 |
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