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| 1 | Single-port versus multi-port cholecystectomy for patients with acute cholecystitis: a retrospective comparative analysis显示文摘BACKGROUND: Trans-umbilical single-port laparoscopic cholecystectomy for chronic gallbladder disease is becoming increasingly accepted worldwide. But so far, no reports exist about the challenging single-port surgery for acute cholecystitis. The objective of this study was to describe our experience with single-port cholecystectomy in comparison to the conventional laparoscopic technique. METHODS: Between August 2008 and March 2010, 73 patients with symptomatic gallbladder disease and histopathological signs of acute cholecystitis underwent laparoscopic cholecystec- tomy at our institution. Thirty-six patients were operated on with the single-port technique (SP group) and the data were compared with a control group of 37 patients who were treated with the multi-port technique (MP group). RESULTS: The mean age in the SP group was 61.5 (range 21-81) years and in the MP group was 60 (range 21-94) (P=0.712). Gender, ASA status and BMI were not significantly different. The number of white blood cells was different before [SP: 9.2 (range 2.8-78.4); MP: 13.2 (range 4.4-28.6); P=0.001] and after the operation [SP: 7.8 (range 3.5-184.8); MP: 11.1 (range 5-20.8); P=0.002]. Mean operating time was 88 (range 34-174) minutes in the SP group vs 94 (range 39-209) minutes in the MP group (P=0.147). Four patients (5%) required conversion to an open procedure (SP: 1; MP: 3; P=0.320). During the follow- up period of 332 (range 29-570) days in the SP group and 428 (range 111-619) days in the MP group (P=0.044), eleven (15%) patients developed postoperative complications (P=0.745) and two patients in the SP group required reoperation (P=0.154). CONCLUSIONS: Trans-umbilical single-port cholecystectomy for beginning acute cholecystitis is feasible and the complicationrate is comparable with the standard multi-port operation. In spite of our good results, these operations are difficult to perform and should only be done in high-volume centers for laparoscopic surgery with experience in single-port surgery. | Dietmar Jacob Roland Raakow | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 2 | IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis显示文摘To function optimally,human blood natural killer(NK)cells need to communicate with other immune cells.Previously,it has been shown that NK cells communicate with 6-sulfo LacNAc dendritic cells(slanDCs),which are able to stimulate NK cells in vitro.In this study,we investigated how slanDCs regulate the level of NK cell activation.The secretion of interleukin(IL)-1βby slanDCs during coculture with NK cells increased as a result of signaling via intercellular adhesion molecule-1 on slanDCs following its interaction with lymphocyte functionassociated antigen-1 on NK cells.IL-1βinduced the expression of Fas receptor(CD95)on NK cells.The binding of Fas ligand(CD178)to CD95 induced the apoptosis of activated NK cells.Moreover,IL-1βalso induced increased cyclooxygenase-2 expression in slanDCs,which in turn enabled the cells to secrete prostaglandin(PG)-E2.Consequently,PGE2 acted as a suppressing agent,tuning down the activation level of NK cells.In summary,IL-1βlimits the level of NK cell activation by inducing apoptosis and suppression as a homeostatic regulatory function. | Dejene Milkessa Tufa Fareed Ahmad Debanjana Chatterjee Gerrit Ahrenstorf Reinhold Ernst Schmidt Roland Jacobs | 2017 | Cellular & Molecular Immunology2017，14，12： | 2 |
| 3 | Unenhanced brain CT is useful to decide on further imaging in suspected venous sinus thrombosis显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，1： | 1 |
| 4 | Unenhanced brain CT is useful to decide on further imaging in suspected venous sinus thrombosis 显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，1： | 1 |
| 5 | Unenhanced brain CT is useful to decide on further imaging in suspected ve- nous sinus thrombosis 显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，1： | 1 |
| 6 | Unenhanced brain CT is useful to decide on further imaging in suspected venous sinus thrombosis显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，1： | 1 |
| 7 | CD26 expression determines lung metastasis in mutant F344 rats: involvement of NK cell function and soluble CD26显示文摘 | Kiyoshi Shingu Andreas Helfritz Margot Zielinska-Skowronek Dirk Meyer-Olson Roland Jacobs Reinhold E. Schmidt Rolf Mentlein Reinhard Pabst Stephan H?rsten | 2003 | Cancer Immunology Immunotherapy2003，，9： | 1 |
| 8 | Unenhanced brain CT is use- ful to decide on further imaging in suspected venous sinus thrombosis 显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，1： | 1 |
| 9 | Phylogeographic analysis and genetic cluster recognition for the conservation of Ural Owls ( Strix uralensis ) in Europe显示文摘 | Roland Hausknecht Susanne Jacobs J?rg Müller Richard Zink Hans Frey Roar Solheim Al Vrezec Anton Kristin Jozef Mihok Ilze Kergalve Pertti Saurola Ralph Kuehn | 2014 | Journal of Ornithology2014，，： | 1 |
| 10 | Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo显示文摘 | Anusara Daenthanasanmak Gustavo Salguero Sylvia Borchers Constanca Figueiredo Roland Jacobs Bala Sai Sundarasetty Andreas Schneider Axel Schambach Britta Eiz-Vesper Rainer Blasczyk Eva M. Weissinger Arnold Ganser Renata Stripecke | 2012 | Vaccine2012，，34： | 1 |
| 11 | Unenhanced brain CT is useful to decide on further imaging in suspected venous sinus thrombosis显示文摘 | Roland T Jacobs J Rappaport A | 2010 | Clin Radiol2010，65，： | 1 |
| 12 | 比尔和梅琳达·盖茨大厅显示文摘位于纽约州的盖茨大厅坐落在康奈尔大学校园中,采用悬挑式的入口雨篷覆盖着富有动感的不锈钢板材,遮蔽了一处户外广场,学生的社交空间周边设有当地的植物和雕塑。极具表现力的钢表皮以棱角分明的方式交织在一起并环绕整个立面,为教室提供遮阳保护,并构建出不断变化而又充满活力的表面。表皮的图案、几何形式和细节的设计都采用了先进的数字模型工具,这足以说明计算机技术对艺术和科学所产生的深远影响。建筑的功能是为社交和学术交流提供场地,让教学不再局限在课堂环境中。主要的交通流线围绕着建筑西侧的玻璃中庭来组织,那里的落地玻璃立面、天窗和玻璃构成的室内围护结构让人对各个楼层内举行的活动间的联系一目了然。被非正式学习空间和集体活动空间环绕的中庭在各个学科间建立了文字上和视觉上的联系。 | Jacob Roland Halbe | 2015 | 设计2015，28，11： | 0 |
| 13 | 康奈尔大学学术厅显示文摘这是位于美国康奈尔大学的BILL&MELINDA GATES学术厅。该项目将重新激活校园这一从前未充分利用的角落,创建一个新的校园门户。建筑裹以动感的不锈钢面板,悬挑的入口顶棚覆盖了一个户外广场空间和学生交流空间,周边设有当地绿化和雕塑。 | Jacob Roland Halbe | 2015 | 设计2015，28，4： | 0 |
| 14 | Gully Erosion Study and Control: A Case Study of Queen Ede Gully in Benin City显示文摘 | Jacob O. Ehiorobo Roland O. Ogirigbo | 2013 | Journal of Civil Engineering and Architecture2013，7，10： | 0 |
| 15 | Role of CD20^+ T cells in multiple sclerosis:implications for treatment with ocrelizumab显示文摘Features of CD20^+T cells:CD20 is a membrane-spanning hosphoprotein strongly expressed on the cell surface of B lineage cells and is widely regarded as a B cell specific marker.However,CD20(Figure 1)is also expressed at a low level on a small subset of CD3^+T cells which therefore are sometimes referred to as CD20dimCD3^+T cells in contrast to CD20brightCD19^+B cells which represent the majority of cells expressing CD20(Hultin et al.,1993).The amount of the CD20 antigen has been assessed to be 25 to 50 times higher on CD20^+CD19^+B cells compared to CD20^+CD3^+T cells(Hultin et al.,1993).At first description of this cell population the frequency of these CD20^+T cells has been described to represent an average of 2.4%of all peripheral blood lymphocytes(50 healthy controls)(Hultin et al.,1993). | Stefan Gingele Thomas Skripuletz Roland Jacobs | 2020 | Neural Regeneration Research2020，15，4： | 0 |
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