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| 1 | Are probiotics useful in Helicobacter pylori eradication?显示文摘Helicobacter pylori(H. pylori) is considered an etiologic factor for the development of peptic ulcer disease,gastric adenocarcinoma, and MALT lymphoma.Therapeutic schemes to eradicate the bacteria are based on double antibiotic therapy and proton pump inhibitor. Despite many therapeutic improvements in H. pylori eradication treatment, it is still associated with high infection rate also in developed countries.Bacterial resistance and adverse events occurrence are among most frequent causes for anti- H. pylori treatment failure. Several studies have reported that certain probiotic strains can exhibit inhibitory activity against H. pylori bacteria. In addition, some probiotic strains can reduce the occurrence of side effects due to antibiotic therapy and consequently increase the H.pylori eradication rate. The results of the prospective double-blind placebo-controlled studies suggest that specific probiotics, such as S. boulardii and L.johnsonni La1 probably can diminish the bacterial load,but not completely eradicate the H. pylori bacteria.Furthermore, it seems that supplementation with S. boulardii is a useful concomitant therapy in the standard H. pylori eradication treatment protocol and most probably increases eradication rate. L. reuteri is equally effective, but more positive studies are needed. Finally, probiotic strains, such as S. boulardii,L. reuteri and L. GG, decrease gastrointestinal antibiotic associated adverse effects. | Matjaz Homan Rok Orel | 2015 | World Journal of Gastroenterology2015，21，37： | 29 |
| 2 | Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease显示文摘It has been presumed that aberrant immune response to intestinal microorganisms in genetically predisposed individuals may play a major role in the pathogenesis of the inflammatory bowel disease, and there is a good deal of evidence supporting this hypothesis. Commensal enteric bacteria probably play a central role in pathogenesis, providing continuous antigenic stimulation that causes chronic intestinal injury. A strong biologic rationale supports the use of probiotics and prebiotics for inflammatory bowel disease therapy. Many probiotic strains exhibit anti-inflammatory properties through their effects on different immune cells, proinflammatory cytokine secretion depression, and the induction of anti-inflammatory cytokines. There is very strong evidence supporting the use of multispecies probiotic VSL#3 for the prevention or recurrence of postoperative pouchitis in patients. For treatment of active ulcerative colitis, as well as for maintenance therapy, the clinical evidence of efficacy is strongest for VSL#3 and Escherichia coli Nissle 1917. Moreover, some prebiotics, such as germinated barley foodstuff, Psyllium or oligofructose-enriched inulin, might provide some benefit in patients with active ulcerative colitis or ulcerativecolitis in remission. The results of clinical trials in the treatment of active Crohn's disease or the maintenance of its remission with probiotics and prebiotics are disappointing and do not support their use in this disease. The only exception is weak evidence of advantageous use of Saccharomyces boulardii concomitantly with medical therapy in maintenance treatment. | Rok Orel Tina Kamhi Trop | 2014 | World Journal of Gastroenterology2014，20，33： | 27 |
| 3 | Novel mechanisms in functional dyspepsia显示文摘机能性消化不良(FD ) 是多重病原的机制涉及的高度流行却异构的混乱。尽管有许多研究,调查了各种各样的 pathophysiologic 机制,与 FD 联系的内在的随便小径仍然保持阴暗。与 FD 联系的当前建议的 pathophysiologic 机制包括基因危险性,推迟以及加速胃的倒空的、内脏的超敏性到酸或机械膨胀,损害胃的住所,反常底的的局面的收缩,反常 antro 十二指肠的活动性,急性、长期的感染,和精神分析社会 comorbidity。位于 FD 下面的畸形的更大的理解可以导致改进管理。这篇社论的目的是在机能性消化不良提供当前的 pathophysiologic 概念的批评概述。 | Rok Son Choung Nicholas J Talley | 2006 | World Journal of Gastroenterology2006，12，5： | 25 |
| 4 | Prognostic factors in patients with node-negative gastric carcinoma:A comparison with node-positive gastric carcinoma显示文摘瞄准:识别淋巴的 clinicopathological 特征节点否定的胃的癌,并且另外在淋巴评估结果指示物节点否定的病人。方法:2848 个胃的癌病人,(53.5%) 1524 是淋巴节点否定。统计分析用艇长模型被执行估计结果指示物。结果:在在节点否定的淋巴和淋巴之间的再发率有有效差量节点积极的病人(14.4% 对 41.0% , P<0.001 ) 。5 年的幸存率在比在淋巴节点积极的淋巴是显著地更低的节点否定的病人(31.1% 对 77.4% , P<0.001 ) 。Univariate 分析表明下列因素影响了 5 年的幸存率:耐心的年龄,肿瘤尺寸,侵略的深度,肿瘤地点,起作用的类型,和在起始的诊断的肿瘤舞台。比例的危险回归建模的艇长表明那种肿瘤尺寸, serosal 侵略,和治愈可能性是独立的,淋巴的统计上重要的、预示的指示物节点否定的胃的癌。结论:淋巴节点否定的病人与相对大的肿瘤和 serosal 侵略让对高治愈可能性,而是病人可归因的有利结果有差的预后。治愈可能性是为淋巴的长期的幸存的最可靠的预言者之一节点否定的胃的癌病人。 | Dong Yi Kim Kyeung Won Seo Jae Kyoon Joo Young Kyu Park Seong Yeob Ryu Hyeong Rok Kim Young Jin Kim Shin Kon Kim | 2006 | World Journal of Gastroenterology2006，12，8： | 20 |
| 5 | Ischemic colitis associated with intestinal vasculitis: Histological proof in systemic lupus erythematosus显示文摘I schemic colitis is an uncommon complication in patients with systemic lupus erythematosus (SLE). In previously reported cases of colitis caused by SLE, intestinal vasculitis is implicated as the causative process, but is rarely confirmed histologically. We described a case of a 32-year-old man with increased activity of SLE, who presented with hematochezia and abdominal pain due to ischemic colitis with small vessel vasculitis which was proven by sigmoidoscopic biopsy. The clinical course of the patient was improved after steroid and conservative management. | Jeong Rok Lee Chang Nyol Paik Jin Dong Kim Woo Chul Chung Kang-Moon Lee | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 6 | Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis显示文摘A 68-year-old man underwent laparoscopic low anterior resection for rectal carcinoma in December 2006.Nearly 19 mo after the operation,he developed recurrent rectal cancer with peritoneal metastasis. In September 2008,he subsequently underwent a laparotomy with a peritonectomy,omentectomy, splenectomy,and a Hartmann procedure.Hyperthermic intraperitoneal oxaliplatin 750 mg was administered. The patient was discharged with no postoperative complications and has been well with postoperative FOLFOX chemotherapy. | Jung Wook Huh Young Jin Kim Hyeong Rok Kim | 2009 | World Journal of Gastroenterology2009，15，6： | 5 |
| 7 | Photonic structures in radiative cooling显示文摘Radiative cooling is a passive cooling technology without any energy consumption,compared to conventional cooling technologies that require power sources and dump waste heat into the surroundings.For decades,many radiative cooling studies have been introduced but its applications are mostly restricted to nighttime use only.Recently,the emergence of photonic technologies to achieves daytime radiative cooling overcome the performance limitations.For example,broadband and selective emissions in mid-IR and high reflectance in the solar spectral range have already been demonstrated.This review article discusses the fundamentals of thermodynamic heat transfer that motivates radiative cooling.Several photonic structures such as multilayer,periodical,random;derived from nature,and associated design procedures were thoroughly discussed.Photonic integration with new functionality significantly enhances the effciency of radiative cooling technologies such as colored,transparent,and switchable radiative cooling applications has been developed.The commercial applications such as reducing cooling loads in vehicles,increasing the power generation of solar cells,generating electricity,saving water,and personal thermal regulation are also summarized.Lastly,perspectives on radiative cooling and emerging issues with potential solution strategies are discussed. | Minjae Lee Gwansik Kim Yeongju Jung Kyung Rok Pyun Jinwoo Lee Byung-Wook Kim Seung Hwan Ko | 2023 | Light(Science & Applications)2023，12，7： | 3 |
| 8 | Lymphovascular or Perineural Invasion May Predict Lymph Node Metastasis in Patients With T1 and T2 Colorectal Cancer显示文摘 | Jung Wook Huh Hyeong Rok Kim Young Jin Kim | 2010 | Journal of Gastrointestinal Surgery2010，，： | 2 |
| 9 | Operative stabilization of the remaining mobile segment in ankylosed cervical spine in systemic onset- juvenile idiopathic arthritis:A case report显示文摘We describe a case of a 19-year-old young man with oligoarthritis type of juvenile idiopathic arthritis, who presented with several month duration of lower neck pain and progressive muscular weakness of all four limbs. X-rays of the cervical spine demonstrated spontaneous apophyseal joint fusion from the occipital condyle to C6 and from C7 to Th2 with marked instability between C6 and C7. Surgical intervention began with anterolateral approach to the cervical spine performing decompression, insertion of cage and anterior vertebral plate and screws, followed by posterior approach and fixation. Care was taken to restore sagittal balance. The condition was successfully operatively managed with multisegmental, both column fixation and fusion, resulting in pain cessation and resolution of myelopathy. Postoperatively, minor swallowing difficulties were noted, which ceased after three days. Patient was able to move around in a wheelchair on the sixth postoperative day. Stiff neck collar was advised for three months postoperatively with neck pain slowly decreasing in the course of first postoperative month.On the follow-up visit six months after the surgery patient exhibited no signs of spastic tetraparesis, X-rays of the cervical spine revealed solid bony fusion at single mobile segment C6-C7. He was able to gaze horizontally while sitting in a wheelchair. Signs of myelopathy with stiff neck and single movable segment raised concerns about intubation, but were successfully managed using awake fiber-optic intubation. Avoidance of tracheostomy enabled us to perform an anterolateral approach without increasing the risk of wound infection. Regarding surgical procedure, the same principles are obeyed as in management of fracture in ankylosing spondylitis or Mb. Forestrier. | Lovro Suhodolcan Marko Mihelak Janez Brecelj Rok Vengust | 2016 | World Journal of Orthopedics2016，7，7： | 2 |
| 10 | Epidemiology of IBS显示文摘 | Rok Seon Choung G. Richard Locke | 2011 | Gastroenterology Clinics of North America2011，，1： | 2 |
| 11 | The effects of anti-vascular endothelial growth factor agents on human retinal pigment epithelial cells under high glucose conditions显示文摘AIM: To investigate the effects of high glucose levels and anti-vascular endothelial growth factor(VEGF) agents(bevacizumab,ranibizumab and aflibercept) on retinal pigment epithelium(RPE) cells.METHODS: ARPE-19 cells were cultured at different glucose levels(5.5 mmol/L,25 mmol/L,and 75 mmol/L).Cell viability was evaluated by MTT assay at 3d after treatment with D-glucose.Cell migration ability was measured by wound healing assay at 3d.A cell death detection kit was used to assess apoptosis at 3 and 14 d.Cell proliferation was assessed by EdU assay at 3d.The culture medium was treated with anti-VEGF agents at clinically relevant concentrations.The experiment was then repeated at a different glucose level.RESULTS: The viability and migration of ARPE-19 cells were significantly decreased in the presence of 75 mmol/L as compared to 5.5 mmol/L glucose.The percentage of TUNEL-positive cells was significantly increased and the proliferative potential was decreased with 75 mmol/L compared to 5.5 mmol/L glucose.There were no significant differences in the results between 25 mmol/L and 5.5 mmol/L glucose.In the presence of 75 mmol/L glucose,the groups treated with anti-VEGF showed decreased cell viability and proliferation and increased apoptosis.However,there were no significant differences between the anti-VEGF groups.CONCLUSION: High glucose level decreases the viability,wound healing ability,and proliferation of RPE cells,while increasing apoptosis.Furthermore,anti-VEGF agents interfered with the physiological functions of RPE cells under high-glucose conditions,accompanied by decreases in cell viability and proliferation. | Jong Rok Oh Jung Woo Han Yoon Kyung Kim Young-Hoon Ohn Tae Kwann Park | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 2 |
| 12 | Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists显示文摘AIM: To present evidence and formulate recommendations for sedation in pediatric gastrointestinal(GI) endoscopy by non-anesthesiologists.METHODS: The databases MEDLINE, Cochrane and EMBASE were searched for the following keywords 'endoscopy, GI', 'endoscopy, digestive system' AND 'sedation', 'conscious sedation', 'moderate sedation', 'deep sedation' and 'hypnotics and sedatives' for publications in English restricted to the pediatric age. We searched additional information published between January 2011 and January 2014. Searches for(upper) GI endoscopy sedation in pediatrics and sedation guidelines by non-anesthesiologists for the adult population were performed. RESULTS: From the available studies three sedation protocols are highlighted. Propofol, which seems to offer the best balance between efficacy and safety is rarely used by non-anesthesiologists mainly because of legal restrictions. Ketamine and a combination of a benzodiazepine and an opioid are more frequently used. Data regarding other sedatives, anesthetics and adjuvant medications used for pediatric GI endoscopy are also presented.CONCLUSION: General anesthesia by a multidisciplinary team led by an anesthesiologist is preferred. The creation of sedation teams led by non-anesthesiologists and a careful selection of anesthetic drugs may offer an alternative, but should be in line with national legislation and institutional regulations. | Rok Orel Jernej Brecelj Jorge Amil Dias Claudio Romano Fernanda Barros Mike Thomson Yvan Vandenplas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 13 | Colonic lymphangiomatosis associated with anemia显示文摘Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia, which was diagnosed and treated with endoscopic snare polypectomy. | Woo Chul Chung Hye-Kang Kim Jin Young Yoo Jeong Rok Lee Kang-Moon Lee Chang Nyol Paik U-Im Jang Jin Mo Yang | 2008 | World Journal of Gastroenterology2008，14，37： | 2 |
| 14 | Development of enterohepatic fistula after embolization in ileal gastrointestinal stromal tumor: A case report显示文摘Gastrointestinal stromal tumor(GIST)is a rare mesenchymal tumor of the gastrointestinal tract that has been associated with the formation of fistulas to adjacent organs in few case reports.However,GIST with enterohepatic fistula has not been reported.Here we report the case of an enterohepatic fistula that occurred after embolization of a liver mass originating in the distal ileum.An 87-year-old woman was hospitalized for melena.On initial conventional endoscopy,a bleeding focus in the gastrointestinal tract was not found.Because of massive hematochezia,enteroscopy was performed through the anus.A protruding,ulcerative mass was found in the distal ileum that was suspected to be the source of the bleeding;a biopsy sample was taken.Electrocoagulation was not successful in controlling the bleeding;therefore,embolization was performed.After embolization,the patient developed a high fever and severe abdominal tenderness with rebound tenderness.Follow-up abdominopelvic computed tomography revealed an enterohepatic fistula between the liver and distal ileum.The fistula was treated surgically by segmental resection of the distal ileum and unlooping of the liver mass. | Yun Ho Lee Ja Seol Koo Chang Ho Jung Sang Yoon Chung Jae Joong Lee Seung Young Kim Jong Jin Hyun Sung Woo Jung Rok Seon Choung Sang Woo Lee Jai Hyun Choi | 2013 | World Journal of Gastroenterology2013，19，43： | 2 |
| 15 | Laparoscopic Anterior 180-Degree Versus Nissen Fundoplication for Gastroesophageal Reflux Disease: Systematic Review and Meta-Analysis of Randomized Clinical Trials显示文摘 | Joris A. Broeders David J. Roks Usama Ahmed Ali David I. Watson Robert J. Baigrie ZhanGuo Cao Jens Hartmann Guy J. Maddern | 2013 | Annals of Surgery2013，，5： | 2 |
| 16 | Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction显示文摘 | Loot AE Roks AJ Henning RH | 2002 | Circulation2002，105，： | 1 |
| 17 | Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations 显示文摘 | Sang Yeob Hana Jong Rok Lee Young Kyu Kwon | 2007 | Journal of Ethnopharmacology2007，114，： | 1 |
| 18 | Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children显示文摘 | Matja? Homan Anja ?terbenc Bo?tjan J. Kocjan Bo?tjan Luzar Nina Zidar Rok Orel Mario Poljak | 2014 | Antonie van Leeuwenhoek2014，，4： | 1 |
| 19 | Effects of angiotensin Ⅱ and angiotensin Ⅱ type 1 receptor blockade on neointimal formation after stent implantation 显示文摘 | Groenewegen HC Van der Harst P Roks A J | 2007 | Int J Cardiol2007，，： | 1 |
| 20 | Forward-backward analysis of RFID-enabled supply chain using fuzzy cognitive map and genetic algorithm显示文摘 | Moon-Chan Kim Chang Ouk Kim S eong Rok Hong Ick-Hyun Kwon | 2008 | Expert Systems with Applications2008，35，： | 1 |
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