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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Silicon Nitride Deposition Rate by Inductively Coupled Plasma Using Silicon and Nitrogen 显示文摘 | LUISSDA S Z RONAIlXD M ROGERIO F | 2002 | Vacuum2002，65，： | 1 |
| 3 | Expression of neuronal isoform of nitric oxide synthase in spinal neurons of neonatal rats after sciatic nerve transection显示文摘 | Rogerio F Teixeira SA Queiroz LS | 2001 | Neurosci Let2001，307，1： | 1 |
| 4 | Shaking table tests of two different reinforcement techniques using polymeric grids on an asymmetric limestone full - scaled structure 显示文摘 | ROGERIO B SILVA M J F | 2009 | Engineering Structures2009，31，6： | 1 |
| 5 | Abeam hardening correction for x-ray microtomography显示文摘 | LYNCH J ELISABETH | 1998 | NDT& E International1998，31，1： | 1 |
| 6 | Detection of Neos- pora caninum DNA in capybaras and phylogenetic analysis显示文摘 | Jesse H T Fabiano M F Rogerio R L | 2010 | Parasitology International2010，59，： | 1 |
| 7 | Innovation networks: From technological development to business model reconfiguration显示文摘 | Rogerio C Guerrini F Moura G | 2007 | Technovation2007，27，8： | 1 |
| 8 | Silicon Nitride Deposition Rate by Inductively Coupled Plasma Using Silicon and Nitrogen 显示文摘 | Luissda S Z Ronaiixd M Rogerio F et ol | 2002 | Vacuum2002，65，： | 1 |
| 9 | Depositional and diagenetic controls on the reservoir quality of lower Cretaceous Pendencia sandstones, Poliguar rift basin, Brazil 显示文摘 | Anjos Sylvia M C dos Deros L F Rogerio desouza Schiffer | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 10 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 11 | Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment 显示文摘 | Rogerio F Jr H J Vieira A S | 2006 | Brain Res2006，1112，： | 1 |
| 12 | Paclitaxel loaded PLGA nanoparticles.: preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Cristina F Sergio S Rogerio G | | 0，，： | 1 |
| 13 | Molecular characterization of vitellin from the ovaries of the white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | GARC VARGAS-ALBORES F ROGERIO R S M | 2002 | Comparative Biochemistry and Physiology2002，133，3： | 1 |
| 14 | Authoring and formatting hypermedia documents in the HyperProp system显示文摘 | Luiz Fernando G Soares Rogerio F Rodrigues | 2000 | Multimedia Systems2000，8，2： | 1 |
| 15 | Depositional and diagenetic controls on the reservoir quality of Lower Cretaceous Pendencia sandstones Potiguar rift basin, Brazil显示文摘 | Sylvia M C dos Anjos Luiz F De Ros Rogerio Schiffer de Souza | 2000 | AAPG Bullentin2000，84，11： | 1 |
| 16 | Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment显示文摘 | Rogerio F Junior Hi Vieira AS | 2006 | J Cell Biol2006，124，12： | 1 |
| 17 | Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction显示文摘 | Jose D Rogerio G P Vinicius F C | 2006 | Nutrition2006，22，5： | 1 |
| 18 | Non-photorealistic camera: Depth edge detection and stylized rendering using multi-flash Imaging 显示文摘 | Raskar R Karhan T Rogerio F | 2004 | ACM Trans on Graphics2004，23，3： | 1 |
| 19 | Wa- ter cooling system using a piezoelectrically actuated flow pump for a medical headlight system显示文摘 | Rogerio F P Sandro L V Amaury R D O | 2008 | Pro- ceedings of SPIE2008，6527，： | 1 |
| 20 | Enhanced depositional and AVO models for lithologically complex sandstone in the Santos Basin, offshore Brazil 显示文摘 | Sabine K Bemhart U Rogerio L F | 2008 | Petroleum Geoscience2008，14，3： | 1 |
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