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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Lead Recovery from a Typical Brazilian Sludge of Exhausted Lead-acid Batteries Using an Electro-hydrometallurgical Process显示文摘 | Luiz C Ferracin Abel E Chacon-Sanhueza Rogerio A | 2002 | Hydrometallurgy2002，65，42： | 1 |
| 3 | Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma显示文摘 | Rogerio A P Kanashiro A Fontanari C | 2007 | Inflammation Res2007，56，10： | 1 |
| 4 | Innovation networks:From technological development to business model reconfiguration显示文摘 | Rogerio C Fabio M G Gilnei L M | 2007 | Technovation2007，27，8： | 1 |
| 5 | Antiinflammatory effect of Queuercetin-loaded microemulsion in the airways allergic inflammatory model in mice显示文摘 | Rogerio A P Dora C L Andrade E L | 2010 | Pharmacological Research2010，61，4： | 1 |
| 6 | Corn posite materials in flexible multibody systems 显示文摘 | MARIA A N JORGE A C ROGERIO P L | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，： | 1 |
| 7 | An- esthesia in glucose 6-phosphate dehydro- genase-deficient patient 显示文摘 | Mucio P Carla C Rogerio S | 2002 | Rev bras An- estesiol2002，52，6： | 1 |
| 8 | Quality characteristics of high pressure-induced hake (Merluccius capensis)protein gels with and without MTGase显示文摘 | CARLOS L C ROGERIO 0 M JORGE A S | 2010 | Journal of Aquatic Food Product Technology2010，19，34： | 1 |
| 9 | Induced sputum and peripheral blood cell profile in chronic obstructive pulmonary disease显示文摘 | ROGERIO R CL(A)UDIA H C HEITOR-SIFFERT P S | 2007 | J Bras Pneumol2007，33，5： | 1 |
| 10 | Innovation networks: From technological development to business model reconfiguration显示文摘 | Rogerio C Guerrini F Moura G | 2007 | Technovation2007，27，8： | 1 |
| 11 | Performance of a polyaniline(DMcT)/carbon fiber composite as cathode for rechargeable lithium batteries显示文摘 | SHEILA C CANOBRE ROGERIO A DAVOGLIO SONIA R BIAGGIO | 2006 | J Power Sour2006，154，1： | 1 |
| 12 | Visualization of ontologies to specify semantic descriptions of serv- ices显示文摘 | J J Samper V R Tomas E Carrillo Rogerio P C Do Nascimento | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，1： | 1 |
| 13 | Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE STUDY) 显示文摘 | Rodrigo J Rogerio A Daniela C | 2006 | Retina2006，26，6： | 1 |
| 14 | Depositional and diagenetic controls on the reservoir quality of lower Cretaceous Pendencia sandstones, Poliguar rift basin, Brazil 显示文摘 | Anjos Sylvia M C dos Deros L F Rogerio desouza Schiffer | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 15 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 16 | Anti-inflammatoryeffects of Lafoensia pacari and ellagic acid in a murine model ofasthma显示文摘 | Rogerio AP Fontanari C Borducchi E | 2008 | Eur J Pharm2008，580，12： | 1 |
| 17 | Depositional and diagenetic controls on the reservoir quality of Lower Cretaceous Pendencia sandstones Potiguar rift basin, Brazil显示文摘 | Sylvia M C dos Anjos Luiz F De Ros Rogerio Schiffer de Souza | 2000 | AAPG Bullentin2000，84，11： | 1 |
| 18 | Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction显示文摘 | Jose D Rogerio G P Vinicius F C | 2006 | Nutrition2006，22，5： | 1 |
| 19 | Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma显示文摘 | ROGERIO A P KANASHIRO A FONTANARI C | 2007 | Inflammation Research2007，56，10： | 1 |
| 20 | Optimum generation control in wind parks when carrying out system operator requests显示文摘 | Rogerio G de A Edgardo D C | 2006 | IEEE Transactions onPowerSystems2006，21，2： | 1 |
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