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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-L-glutamine in rats 显示文摘 | Marcelo M R Julio T Rogerio G P | 2004 | Nutrition Res2004，24，4： | 1 |
| 3 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic wastewater显示文摘 | Michelan Rogerio Zimmer Thiago R Rodrigues Jose A D | 2009 | Journal of Environmental Management2009，90，3： | 1 |
| 4 | Induced sputum and peripheral blood cell profile in chronic obstructive pulmonary disease显示文摘 | ROGERIO R CL(A)UDIA H C HEITOR-SIFFERT P S | 2007 | J Bras Pneumol2007，33，5： | 1 |
| 5 | Effect of forage quality and monensin on the rumenal fermentation of fistulated cows fed continuously at a constant intake显示文摘 | Rogerio P L James B R | 1997 | J Anim Sci1997，75，： | 1 |
| 6 | Detection of Neos- pora caninum DNA in capybaras and phylogenetic analysis显示文摘 | Jesse H T Fabiano M F Rogerio R L | 2010 | Parasitology International2010，59，： | 1 |
| 7 | Resolvin DI and aspirin- triggered resolvin DI promote resolution of allergic airways responses显示文摘 | Rogerio AP Haworth O Croze R | 2012 | J Immunol2012，189，4： | 1 |
| 8 | Performance of a polyaniline(DMcT)/carbon fiber composite as cathode for rechargeable lithium batteries显示文摘 | SHEILA C CANOBRE ROGERIO A DAVOGLIO SONIA R BIAGGIO | 2006 | J Power Sour2006，154，1： | 1 |
| 9 | Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis显示文摘 | John R Basile Rogerio M Castilho | 2006 | Proc Natl Acad Sci U S A2006，103，24： | 1 |
| 10 | Visualization of ontologies to specify semantic descriptions of serv- ices显示文摘 | J J Samper V R Tomas E Carrillo Rogerio P C Do Nascimento | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，1： | 1 |
| 11 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 12 | Molecular characterization of vitellin from the ovaries of the white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | GARC VARGAS-ALBORES F ROGERIO R S M | 2002 | Comparative Biochemistry and Physiology2002，133，3： | 1 |
| 13 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic waste water显示文摘 | Rogerio M Thiago R Z Jose A D | 2009 | Journal of Environmental Management2009，90，5： | 1 |
| 14 | Non-photorealistic camera: Depth edge detection and stylized rendering using multi-flash Imaging 显示文摘 | Raskar R Karhan T Rogerio F | 2004 | ACM Trans on Graphics2004，23，3： | 1 |
| 15 | Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-L-glutamine in rats显示文摘 | MARCELO M R JULIO T ROGERIO G P | 2004 | Nutr Res2004，24，4： | 1 |
| 16 | Wa- ter cooling system using a piezoelectrically actuated flow pump for a medical headlight system显示文摘 | Rogerio F P Sandro L V Amaury R D O | 2008 | Pro- ceedings of SPIE2008，6527，： | 1 |
| 17 | Mo- lecular cloning of a β-glucan-patterwrecognition lipoprotein from the white shrimp Penaeus (Litopenaeus) vannamei: correlations between the deduced amino acid sequence and the native protein structure显示文摘 | Mar a GRF Claudia V R Rogerio R S M etal | 2004 | Developmental and Comparative Immunology2004，28，： | 1 |
| 18 | Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise显示文摘 | Marcelo M R Julio T Rogerio G P | 2006 | Nutrition2006，22，5： | 1 |
| 19 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic wastewater显示文摘 | Rogerio Miehelan Thiago R Zimmer Jose A D Rodrigues Suzana M Ratusznei Deovaldo de Maraes Marcelo Zaiat Eugenio Foresti | 2009 | Journal of Environmental Management2009，90，： | 1 |
| 20 | Maneb enhances MPTP neurotoxicity in mice 显示文摘 | Takahashi RN Rogerio R Zanin M | 1989 | Res Commun Chem Pathol Pharmacol1989，66，： | 1 |
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