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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | 收获沙棘振动器试验研究显示文摘该项研究的核心是研制振动器,通过振动果枝的方式来收获沙棘果实。2003到2004年间,基于我们的试验研究结果显示,沙棘品种'印度夏季'通过用频率为40Hz,振幅为15mm,10s为一振动周期的果枝振动器可有效获得果实。利用这个参数的振动可以有效获得90%的果实,且对果枝的损害很小,从果枝上下来的叶片、芽及木枝的碎片也很少。在2003年进行了最原始的研究,2004年测试发现这种方法存在一定缺陷。发电机利用机轴进行来回的旋转运动,利用这个原理进行各种振幅试验,但这对果树各部分会产生大量的压力。用1.5kW的电机可以在车间及没有农业机械的土地上进行试验,但这个过程需要人工看护。最原始的方法效率不高且过程复杂。2005年进行了设备的改进,通过凸轮产生的振动来驱动液压马达。尽管这种方法使用时间还很短,但是它的振动功能还是非常显著的。如果选在最佳采摘季节收获果实,收获的果实品质最佳,同时对果树的伤害也是最小的。如果在每个季节采摘500株或是更少果树的果实,这种振动收获果实的方法是一种最佳选择。 | 梁月 殷丽强 Roger Chagnon Jérme Boutin Sylvain Fortin | 2009 | 国际沙棘研究与开发2009，7，4： | 3 |
| 3 | Histologic evidence of the safety of endoscopic saphenous vein graft preparation显示文摘 | Meyer DM Rogers TE Jessen ME | 2000 | Ann Thorac Surg2000，70，2： | 1 |
| 4 | Thoracolumbar burst fractures:CT dimensions of the spinal canal relative to post surgical improvement显示文摘 | Shuman WP Rogers JV Sickler ME | 1958 | AJR Am J Roemtgeno1958，145，2： | 1 |
| 5 | Short-Term Effect of a course of manual therapy and exercise in people with moderate chronic obstructive pulmonary disease:a Preliminary Clinical Trial显示文摘 | Roger ME Subramanyam RV Ken B | 2013 | J Manipul Physiol Therapeu2013，36，8： | 1 |
| 6 | Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors显示文摘 | Roger P Sahla ME Sari Makela S | 2001 | Cancer Res2001，61，6： | 1 |
| 7 | Probabilistic risk analysis of slope stability显示文摘 | Whittlestone AP Johnson JD Rogers ME | 1995 | T I MIN METALL A1995，104，： | 1 |
| 8 | Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors显示文摘 | Roger P Sahla ME Makela S | 2001 | Cancer Res2001，61，6： | 1 |
| 9 | Laparoscopic partial nephreetomy: Evaluation of long-term oncological outcome 显示文摘 | Allaf ME Bhayani SB Rogers C | 2004 | J Urol2004，172，3： | 1 |
| 10 | Targeted gene delivery by tropism-modified adenoviral vectors显示文摘 | Douglas JT Rogers BE Rosenfeld ME | 1996 | Nat Biotechnol1996，14，11： | 1 |
| 11 | Coagulase-negative staphylococcal infections 显示文摘 | Rogers KL Fey PD Rupp ME | 2009 | Infect Dis Clin North Am2009，23，1： | 1 |
| 12 | Targeted gene delivery by tropism-modified adenoviral vectors显示文摘 | Douglas JT Rogers BE Rosenfeld ME | 1996 | Nat Biotechnol1996，14，11： | 1 |
| 13 | An olfactory-specific glutathione-S-transferase in the sphinx moth Manduca sexta显示文摘 | Rogers ME Jani MK Vogt RG | 1999 | Exp Biol1999，202，12： | 1 |
| 14 | Interaction be- tween heat shock proteins and antimicrobial peptides 显示文摘 | Otvos L J Rogers ME Consolvo P J | 2000 | Biochemistry2000，39，14： | 1 |
| 15 | Histologic evidence of the safety of endoscopic saphenous vein graft preparation 显示文摘 | Meyer DM Rogers TE Jessen ME | 2000 | Ann Thorac Surg2000，70，2： | 1 |
| 16 | The functional Independence Measure for Children (WeeFIM):conceptual basis and pilot use in children with developmental disabilities显示文摘 | Msall ME DiGaudio K Rogers BT | 1994 | Clin Pediatr1994，70，： | 1 |
| 17 | Histologic evidence of the safety of endoscopic saphenous vein graft preparation 显示文摘 | Meyer DM Rogers TE Jessen ME | 2000 | Ann Thorae Surg2000，70，2： | 1 |
| 18 | Morphine alters macrophage and lymphocyte population in the spleen and peritoneal cavity显示文摘 | Hilburger ME Adler MW Rogers TJ | 1997 | J Neuroimmunol1997，80，12： | 1 |
| 19 | Sipl mediates an E-cadherin- to-N-cadherin switch during cranial neural crest EMT 显示文摘 | Rogers CD Saxena A Bronner ME | 2013 | J Cell Bid2013，203，5： | 1 |
| 20 | Auto-anti-A1:another cause of ABO discrepancy显示文摘 | Rogers VB Reid ME Ellisor SS | 1981 | Transfusion1981，21，1： | 1 |
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