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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 3 | NF-Y and Sp1 are involved in transcriptional regulation of rat SND p102 gene显示文摘 | RODRIGUEZ L OCHOA B MARTINEZ M J | 2007 | Biochem Biophys Res Commun2007，356，1： | 1 |
| 4 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 5 | Genes homologous to ubiquitin-conjugating proteins and eukaryotic transcription factor SII in African swine fever virus显示文摘 | RODRIGUEZ J M SALAS M L VINUELA E | 1992 | Virology1992，186，： | 1 |
| 6 | Effects of inulin and enzyme complex, individually or in combination, on growth performance, intestinal mi- croflora, cecal fermentation characteristics, and jejunal histomorphology in broiler chickens fed a wheat-and barley-based diet显示文摘 | REBOLE A ORTIZ L T RODRIGUEZ M L | 2010 | Poultry Science2010，89，2： | 1 |
| 7 | Spatial patterns and chemical characteristics of root biomass in ecosystems of the Patagonian Monte disturbed by grazing显示文摘 | Rodriguez M V Bertiller M B Sain C L | 2007 | Journal of Arid Environments2007，70，1： | 1 |
| 8 | Perceived value of the purchase of a tourism product显示文摘 | Sanchez J Callarisa L Rodriguez R M | 2006 | Tourism Management2006，，3： | 1 |
| 9 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 10 | Optimal feedforward compensators for systems with right-half plane zeros显示文摘 | RODRIGUEZ C GUZMAN J L BERENGUEL M HAGGLUND T | 2014 | )ournal of Process Control2014，24，4： | 1 |
| 11 | The role of capillary water in the stability of tailing dams 显示文摘 | Zandarfn M T Oldecop L A Rodriguez R | 2009 | Engineering Geology2009，105，2： | 1 |
| 12 | Neonatal expression of amh, sox9 and sf-1 mRNA in Caiman latirostris and effects of in ovo exposure to endocrine disrupting chemicals 显示文摘 | Durando M Cocito L Rodriguez H A | 2013 | General and Comparative Endocrinology2013，191，1： | 1 |
| 13 | Assessment of mitral annulardynamics during diastole by Doppler tissue imaging:comparisonwith mitral doppler inflow in subjects without heart diseaseand in patients with left ventricular hypertrophy显示文摘 | Rodriguez L Garcia M Ares M | 1996 | AmericanHeart Journal1996，131，5： | 1 |
| 14 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 15 | preimplantation genetic diagnosis for spinal muscular atrophy type I 显示文摘 | Fallon L Harton GL Sisson ME Rodriguez E Field LK Fugger EF Geltinger M Sun Y Dorfmann A Schoener C Bick Dm Schulman J Levinson G Black SH | 1999 | Neurology1999，53，： | 1 |
| 16 | African swine fever virus structural protein p54 is essential for the re- cruitment of envelope precursors to assembly sites 显示文摘 | Rodriguez J M Gareia-Escudero R Salas M L | 2004 | J Vir- ol2004，78，8： | 1 |
| 17 | Myocardial wall velocity assessment by pulsed Doppler tissue imaging: characteristic findings in normal subjects显示文摘 | Garcia M J Rodriguez L Ares M | 1996 | Am Heart J1996，132，3： | 1 |
| 18 | Long pho-toperiod on sea cages delays timing of first spermiation and enhances growth in male European sea bass (Di-centrarchus labrax) 显示文摘 | Carrillo M Begtashi I Rodriguez L | 2010 | Aquaculture2010，299，14： | 1 |
| 19 | Influence of groove size on the static and rotordynamic characteristics of short, laminar-flow annular seals 显示文摘 | Childs D W Graviss M Rodriguez L E | 2007 | Journal of Tribology2007，129，2： | 1 |
| 20 | Variation among and within Capsicum species revealed by RAPD markers 显示文摘 | Rodriguez J M Berke T Engle L | 1999 | Theor Appl Genet1999，99，： | 1 |
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