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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Egenhofer: determining semantic similarity among entity classes from different ontologies 显示文摘 | Rodriguez M A Max J | 2003 | IEEE Trans Knowl Data Eng2003，15，2： | 2 |
| 3 | Relationship between soil organic carbon and site characteristics in Peninsular Spain显示文摘 | Hontoria C Rodriguez M J C Saa A | 1999 | Soil Science Society of America Journal1999，63，： | 1 |
| 4 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 5 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 6 | Piscicidal properties of piperovatine from Piper piscatorum 显示文摘 | Marcus A M Rodriguez E | 1998 | J Ethnophar macol1998，60，2： | 1 |
| 7 | Influence of copper on the structural characteristics of carbon nanofibers produced from the cobaltcatalyzed decomposition of ethylene显示文摘 | CHAMBERS A RODRIGUEZ N M BAKER R T K | 1996 | J Mater Res1996，11，2： | 1 |
| 8 | Label free bioelectronic detection of aptamer-protein interaction 显示文摘 | Kawde A N Rodriguez M C Lee T M H | 2005 | Electrochem Commun2005，，7： | 1 |
| 9 | TaqMan real-time PCR for the detection and quantitation of pork in meat mixtures 显示文摘 | Rodriguez M A Garcia T Gonzalez I | 2005 | Meat Science2005，70，： | 1 |
| 10 | Determination of oxytetracycliae in milk samples by polymer inclusion membrane separation coupled to high performance liquid chromatography 显示文摘 | PEREZ-SILVA I RODRIGUEZ J A RAMIREZ-SILVA M T | 2012 | Analytica Chimica Acta2012，718，9： | 1 |
| 11 | Efficiency of chain codes to represent binary objects 显示文摘 | Sdnchez Cruz H Bribiesea E Rodriguez Diaz M A | 2007 | Pattern Recogni- tion2007，40，6： | 1 |
| 12 | Pheochromocytoma of the urinary bladder 显示文摘 | Albores-Saavedra J Maldonado M E Ibarra J Rodriguez H A | 1969 | Cancer1969，23，5： | 1 |
| 13 | Pre- diction of haematoma growth and outcome in patients with in- tracerebral haemorrhage using the CT-angiography spot sign (PREDICT) a prospective observational study显示文摘 | Demchuk A M Dowlatshahi D Rodriguez Luna D | 2012 | Lancet Neu- rol2012，11，4： | 1 |
| 14 | Continuous degradation of a mixture of sulfonamides by Trametes versicolor and identification of metabolites from sulfapyridine and sulfathiazole 显示文摘 | RODRIGUEZ C E GARCIA-GALAN M A BLANQUEZ P | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 15 | Effects of inulin and enzyme complex, individually or in combination, on growth performance, intestinal mi- croflora, cecal fermentation characteristics, and jejunal histomorphology in broiler chickens fed a wheat-and barley-based diet显示文摘 | REBOLE A ORTIZ L T RODRIGUEZ M L | 2010 | Poultry Science2010，89，2： | 1 |
| 16 | An alternative route to the consolidation of mechanically alloyed aluminum powder显示文摘 | RODRIGUEZ J A GALLARDO J M HERRERA E J | 1995 | Materials Transactions1995，36，2： | 1 |
| 17 | Callus induction and a preliminary attempt to obtain cell suspensions from embryos and levels of Juglans regia L 显示文摘 | Rodriguez R Revilla M A Perez C | 1987 | Acta Hort (ISHS)1987，12，： | 1 |
| 18 | Fiber-rich functional fish food from stripped mullet using amidated low methoxyl pectin显示文摘 | RAMIREZ J A RODRIGUEZ N R URESTI R M etal | 2007 | Food HydrocoUoids2007，21，4： | 1 |
| 19 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 20 | Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage显示文摘 | Roquer J Rodriguez Campellp A Gomis M | | 0，，04： | 1 |
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