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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Egenhofer: determining semantic similarity among entity classes from different ontologies 显示文摘 | Rodriguez M A Max J | 2003 | IEEE Trans Knowl Data Eng2003，15，2： | 2 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Schedule generation and reeonfiguration for parallel machines显示文摘 | LUH P B HOITOMT D J MAX E | 1990 | IEEE Transactions on Robotics and Automation1990，6，6： | 1 |
| 5 | Effects of the land application of sewage sludge on soil heavy metal concentrations and soil microbial communities 显示文摘 | Kelly J J Haggblom Max Tate R L | 1999 | Soil Biol Biochem1999，31，10： | 1 |
| 6 | Deriving the Composition of Binary Topological Relation 显示文摘 | MAX J E | 1994 | Journal of Visual Languages and Computing1994，5，2： | 1 |
| 7 | Donor lymphocyte infusion mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen:extinction of graft-versus-leukemia effects after conversion to full donor chimerism显示文摘 | Mapara MY Kim YM Max J | 2003 | Transplantation2003，76，2： | 1 |
| 8 | Quantizing for minimum distortion显示文摘 | MAX J | 1960 | IRE Transactions on Information Theory1960，6，1： | 1 |
| 9 | Hydraulic Ram Pumps for Irrigation in NorthernThailand显示文摘 | INTHACHOT M SAEHAENG S MAX J F J | 2015 | Agriculture and Agricultural Science Procedia2015，5，： | 1 |
| 10 | Infrared spectra of aquous ionic salt mixtures at low concentrations: Ion pairing in water 显示文摘 | Max J J Chapados C | 2007 | The Journal of Chem Phys2007，127，11： | 1 |
| 11 | Generation of neotendon using synthetic polymers seeded with tenocytes显示文摘 | Cao Y Vacanti J P Max | 2000 | Transplant Proc2000，32，： | 1 |
| 12 | The first genetic linkage map of Luohanguo (Siraitia grosvenorii) based on ISSR and SRAP markers显示文摘 | LIU L H MAX J WEI J H | 2011 | Genome2011，54，1： | 1 |
| 13 | Effects of nitrogen on grown-in oxygen precipitates in large diameter Czochralski silicon 显示文摘 | YU X G YANG D R YANG J S MAX Y LI L B QUE D L | 2003 | Chin J Semicond2003，24，1： | 1 |
| 14 | Effects of heavy phosphorus-doping on mechanical properties of Czochralski silicon显示文摘 | ZENG Z D MAX Y CHEN J H | 2010 | Journal of Applied Physics2010，107，： | 1 |
| 15 | Global Cancer Statistics, 2002显示文摘 | D Max Parkin Freddie Bray J Ferlay | 2005 | CA Cancer J Clin2005，55，： | 1 |
| 16 | Point-set Topological Spatial Relations显示文摘 | MAX J EGENHOFER ROBERT D FRANZOSA | 1991 | International Journal of Geographical Information Science1991，11，2： | 1 |
| 17 | Ultra deep desulfurization and denitrogenation of diesel fuel by selective adsorption over three different adsorbents: A study on adsorptive selectivity and mechanism显示文摘 | KIM J H MAX L | 2006 | Catalysis Today2006，111，12： | 1 |
| 18 | Global cancer statistics,2002显示文摘 | D Max Parkin FreddieBray J Ferlay | 2005 | CA CancerJ Clin2005，55，2： | 1 |
| 19 | Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemisphere stroke显示文摘 | Max W Nancy J F Wade S S | 2005 | Am J Neuroradiol2005，26，1： | 1 |
| 20 | soja under NaC1 stress 显示文摘 | Luo Q Y Yu B J Liu Y L Differential sensitivity to chloride and sodium ions in seedlings of Glycine max and G | 2003 | Journal of Plant Physiology2003，16，： | 1 |
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