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| 1 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 2 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 3 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 4 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 5 | Dyslipidemia: evidence of efficacy of the pharmacological and non-pharmacological treatment in the elderly显示文摘为心血管的疾病(CVD ) 控制风险因素在的临床的决定老考虑下列:(1 ) 老预期寿命;(2 ) 老生物年龄和功能的能力;(3 ) 在老组的心血管的疾病的角色;(4 ) 风险因素在的流行老;并且(5 ) 风险因素在的治疗的有效性老。很多研究显示出 dyslipidemia 的第二等、主要的预防的功效在老。然而,在 80 年包括了病人的唯一的审判是心保护学习(HPS ) 。Statins 为阴沉的低密度的脂蛋白胆固醇(LDL-C ) 被认为第一线治疗。因为生活方式变化是很困难的完成,医生们一般来说趋于开许多药控制心血管的风险因素。然而,健康食物消费在主要、第二等的心血管的预防仍然是一块奠基石并且应该被每个人实现。 | Claudia F Gravina Marcelo Bertolami Giselle HP Rodrigues | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 6 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 7 | Enhanced flotation of sulfide fines using the emulsified oil extender technique显示文摘 | Rubio J Capponi F Rodrigues R T | 2007 | Int J Miner Process2007，84，14： | 1 |
| 8 | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats 显示文摘 | Gondim F A Rodrigues C L da-Graca J R | 2001 | Auton Neurosci2001，87，1： | 1 |
| 9 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 10 | Ti-Al-V powder metallurgy (PM) via the hydrogenation dehydrogenation (HDH) process 显示文摘 | AZEVEDO C R F RODRIGUES D NETO F B | 2003 | Journal of Alloys and Compounds2003，353，12： | 1 |
| 11 | Response surface analysis and sinulation as tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 12 | Crane scheduling with spatial constraints显示文摘 | Lim A Rodrigues B Xiao F | 2004 | Naval Research Logistics2004，51，： | 1 |
| 13 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 14 | S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians显示文摘 | Persson I Aklillu E Rodrigues F | 1996 | Pharmacogenetics1996，6，： | 1 |
| 15 | An expeditiousmethod for the determ ination of organochlorine pesticides resi-dues in estuarine sediments using microwave assisted pre-ex-traction an d automa ted headspace solid phase microextractioncoupled to gas chromatography-mass spectrometry显示文摘 | Carvalho P N Rodrigues P N R Alves F | 2008 | Talan-ta2008，76，5： | 1 |
| 16 | Optimization of the production of biodiesel from soybean oil by ultrasound assisted methanolysis显示文摘 | SANTOS F F P RODRIGUES S FERNANDES F A N | | 0，，： | 1 |
| 17 | Char- acterization of complex networks: a survey of measurements 显示文摘 | COSTA L F RODRIGUES F A TRAVIESO G | 2007 | Advances in Physics2007，56，1： | 1 |
| 18 | Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid 显示文摘 | Silva R F Rodrigues C M Brites D | 2001 | J Hepatol2001，34，3： | 1 |
| 19 | Adsorption equilibria and kinetics for propylene and propane over 13X and 4A zeolites pellets显示文摘 | RODRIGUES A E | 1999 | Ind Eng Chem Res1999，38，5： | 1 |
| 20 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
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