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| 1 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 2 | Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke:a comprehensive analysis using data from primary care 显示文摘 | Feary JR Rodrigues LC Smith CJ | 2010 | Thorax2010，65，11： | 1 |
| 3 | Effect of dequalinium on the oxidative stress in Plasmodium berghei-infected erythrocytes 显示文摘 | Rodrigues JR Gamboa ND | 2009 | Parasitol Res2009，104，6： | 1 |
| 4 | Perspective on fluid and solid dynamics in different pars plana vitrectomy systems显示文摘 | Magalh(a)es O Jr Maia M Rodrigues EB | | 0，，： | 1 |
| 5 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 6 | Snake venom phospholipases A2 : a new class of antitumor agents 显示文摘 | Rodrigues RS Izidoro LF de Oliveira RJ Jr | 2009 | Protein Pept Lett2009，16，： | 1 |
| 7 | Tobacco use before and after liver transplantation: a single center survey and implications for clinical practice and research 显示文摘 | Ehlers SE Rodrigue JR Widows MR | 2004 | Liver Transpl2004，10，3： | 1 |
| 8 | Statinmonotherapy attenuates renal injury in a salt-sensitive hy-pertension model of renal disease显示文摘 | Vieira JM Jr Rodrigues LT Mantovani E et a1 | 2005 | Nephron Physiol2005，101，4： | 1 |
| 9 | Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/ emotional, and cognitive outcomes in children显示文摘 | Rodrigue JR Balistreri W Haber B | 2011 | Hepatology2011，53，5： | 1 |
| 10 | The help-seekingby women with urinary incontinence in Brazil显示文摘 | Rios AA Cardoso JR Rodrigues MA | 2011 | Int Urogy-necol J2011，22，7： | 1 |
| 11 | The Psychosocial Adjustment to Illness Scale-Self Report:factor structure and item stability显示文摘 | Rodrigue J R Kanasky Jr W F Jackson S I | 2000 | Psychol Assess2000，12，4： | 1 |
| 12 | Paving the way for predictive diagnostics and personali- zed treatment of invasive aspergillosis显示文摘 | Oliveira-Coelho A Rodrigues F Campos A Jr | 2015 | Front Microbiol2015，6，： | 1 |
| 13 | Mechanisms of pulmonary injury 显示文摘 | Turino GM Rodrigues JR Greenbaum LM | 1974 | Am J Med1974，57，3： | 1 |
| 14 | Phylloseptins: a novel class of anti - bacterial and anti - protozoan peptides from the Phyllomedusa genus 显示文摘 | Leite JR Silva LP Rodrigues MI | 2005 | Peptides2005，26，4： | 1 |
| 15 | Extendedpericranial flap and bone graft reconstruction in anteriorskull base surgery显示文摘 | Rodrigues M O'malley BW Jr Staecker H | 2004 | Otolaryngol Head Neck Surg2004，131，1： | 1 |
| 16 | Erlotinib in previously treated non-small-cell lung cancer 显示文摘 | Shepherd FA Rodrigues Pereira JR Ciuleanu T | 2005 | N Engl J Med2005，353，： | 1 |
| 17 | Erlotinib in previously treated non-small cell lung cancer显示文摘 | Shepherd FA Rodrigues Pereira JR Ciuleanu T | 2005 | N Engl J Med2005，353，2： | 1 |
| 18 | Medical coping modes questionnaire:Factor structure for adult transplant candidates显示文摘 | Rodrigue JR Jackson SI Perri MG | 2000 | International Journal of Behavioral Medicine2000，7，2： | 1 |
| 19 | Adjunct controlled inversion therapy following extracorporeal shock wave lithotripsy for lower pole ealieeal stonas显示文摘 | Rodrigues Netto N Jr Claro JF Cortado PL | 1991 | J Urol1991，146，4： | 1 |
| 20 | Development of an injectable formulation of albendazole and in vivo evaluation of its eflficacy against Echinococcus multilocularis metacestode显示文摘 | Rodrigues JM Jr Bories C Emery I | | 0，，12： | 1 |
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