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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Heliox for nonintubated acute asthma patients显示文摘 | Rodrigo G Pollack C Rodrigo C | | 0，，4： | 1 |
| 3 | A meta-analysis of the effects of ipratropium bromide in adults with acute asthma显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | Am Med1999，107，： | 1 |
| 4 | Heliox for treatment of exacerbations of chronic obstructive pulmonary disease显示文摘 | Rodrigo G Pollack C Rodrigo C | 2002 | Cochrane Database Syst Rev2002，，00： | 1 |
| 5 | A meta-analysis of the effects of ipratropium bromide in adults with acute asthma显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | American Journal of Medicine1999，107，4： | 1 |
| 6 | Biodegradation studies of cellulose and its vinylic graft copolymers by thermal analysis and mechanical spectroscopy 显示文摘 | FLAQUE C RODRIGO L C KIBES G A | 2000 | J Appl Polym Sci2000，76，3： | 1 |
| 7 | Subarachnoid hemorrhage following persmissivehypercapnia in a patient with severe acute asthma显示文摘 | Rodrigo C Rodrigo G | 1999 | Am J Emerg Med1999，17，7： | 1 |
| 8 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 9 | Small cell neuroendocrine carcinoma of the cervix : report of two cases 显示文摘 | Puig F Rodrigo C Mufioz G | 2009 | Eur J Gynaecol 0ncol2009，30，3： | 1 |
| 10 | E-work based collaborative optimization approach for strategic logistic显示文摘 | PABLO A M RODRIGO A G JOSE A C | 2009 | Computers & Industrial Engineering2009，57，1： | 1 |
| 11 | A randomised crossover comparison of patient - controlled sedation and patient - maintained sedation using propofol 显示文摘 | RODRIGO M R IRWIN M G TONG C K | 2003 | Anaesthesia2003，58，4： | 1 |
| 12 | Quality changes in fresh- cut pear slices as affected by controlled atmospheres and chemical preservatives显示文摘 | James R G Betty H P Rodrigo A C | 2002 | Postharvest Bio Technol2002，24，： | 1 |
| 13 | Numerical stabilization of Biot’s consolidation model by a perturbation on the flow equation 显示文摘 | AGUILAR G GASPAR F J LISBONA F RODRIGO C | 2008 | International Journal for Numerical Methods in Engineering2008，75，11： | 1 |
| 14 | ATP-sensitive potassium channels 显示文摘 | Rodrigo G C Standen N B | 2005 | Curr Pharm Design2005，11，15： | 1 |
| 15 | Heliox for treatment of exacerbations of chronic obstructive pulmonary disease显示文摘 | Rodrigo G Pollack C Rodrigo C | 2002 | Cochrane Database Syst Rev2002，2，00： | 1 |
| 16 | A meta - analysis of the effects of ipratropium bromide in adults with acute asthma 显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | Am J Med1999，107，4： | 1 |
| 17 | Heliox for treatment of exacerbations of chronic obstructive pulmonary disease 显示文摘 | Rodrigo G Pollack C Rodrigo C | 2002 | Cochrane Database Syst Rev2002，，00： | 1 |
| 18 | Efficacy of magnesium sulfate in acute adult asthma:a meta-analysis of randomized trials显示文摘 | Rodrigo G Rodrigo C Burschtin O | 2000 | Am J Emerg M ed2000，18，2： | 1 |
| 19 | Melt func-tionalization of EVA copolymers with maleic anhydride显示文摘 | BLUMA G SOARES RODRIGO S C Colombaretti | 1999 | J appl polym sci1999，72，14： | 1 |
| 20 | Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility 显示文摘 | Wang G Y Bergman M R Nguyen A P Turcato S Swigart P M Rodrigo M C | 2006 | Cardiovasc Res2006，69，： | 1 |
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