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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 3 | Assessment of glomerular filtration rate in transplant recipients with severe renal insufficiency by Nankivell,Modification of Diet in Renal Disease(MDRD),and Cockroft-Gault equations显示文摘 | Rodrigo E Fernandes-Fresnedo G Ruiz JC | 2003 | Transplant Proc2003，35，： | 1 |
| 4 | Dynamic consequences of prey refuges in a simple model system: more prey, fewer predators and enhanced stability显示文摘 | EDUARDO G RODRIGO R | 2003 | Ecol Model2003，166，： | 1 |
| 5 | First Ordovician vertebrate from South America显示文摘 | Gagaer P Y Blieck A Rodrigo G S | 1986 | Geobios1986，19，： | 1 |
| 6 | Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta analysis 显示文摘 | RODRIGO G J NANNINI L J | 2007 | Pulm Pharmaeol Ther2007，20，5： | 1 |
| 7 | Heliox for nonintubated acute asthma patients显示文摘 | Rodrigo G Pollack C Rodrigo C | | 0，，4： | 1 |
| 8 | Liver NF-κB and AP-1 DNA binding in obese patients显示文摘 | Videla LA Tapia G Rodrigo R | 2009 | Obesity2009，17，5： | 1 |
| 9 | Channel plasmon-polaritons:modal shape,dispersion,and losses显示文摘 | Moreno E Garcia-Vidal F J Rodrigo S G | | 0，，23： | 1 |
| 10 | Guiding and focusing of electromagnetic fields with wedge plasmon polaritons显示文摘 | Moreno E Rodrigo S G Bozhevolnyi S I | | 0，，02： | 1 |
| 11 | Guiding and focusing of electromagnetic fields with wedge plasmon polaritons 显示文摘 | MORENO E RODRIGO S G BOZHEVOLNYI S I | 2008 | Physical Review Letters2008，100，02： | 1 |
| 12 | Alosetron relievespain and improves bowel function compared with mebeverine infemale nonconstipated irritable bowel syndrome patients显示文摘 | Jones RH Holtmann G Rodrigo L | 1999 | Aliment Pharmacol Ther1999，13，11： | 1 |
| 13 | Performance evaluation of collision-reaction interface and internal standardization in quadrupole ICP-MS measurements 显示文摘 | Rodrigo F S S Marcelo B B G Edenir R P | 2011 | Talanta2011，86，： | 1 |
| 14 | Renal damage mediated by oxidative stress: a hypoth-esis of protective effects of red wine显示文摘 | Rodrigo R Rivera G | 2002 | Free Radic Biol Med2002，33，3： | 1 |
| 15 | A rare case of synchro- nous malignant thoracic tumors 显示文摘 | Benoit JB Marcos M Rodrigo G | 2009 | J Bras Pneumol2009，35，2： | 1 |
| 16 | Tiotropium for the treatment of adolescents with moderate tosevere symptomatic asthma:a systematic review with meta-analysis显示文摘 | Rodrigo G J Castro-Rodríguez J A | 2015 | Ann Allergy Asthma Immunol2015，115，3： | 1 |
| 17 | A meta-analysis of the effects of ipratropium bromide in adults with acute asthma显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | Am Med1999，107，： | 1 |
| 18 | The role of anti leukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials显示文摘 | RODRIGO G J YANEZ A | 2006 | Ann Allergy Asthma Immunol2006，96，： | 1 |
| 19 | Inhibition of protein kinases AKT and ERK1/2 reduce the carotid body chemoreceptor response to hypoxia in adult rats显示文摘 | Iturri P Joseph V Rodrigo G | 2015 | Adv Exp Med Biol2015，860，： | 1 |
| 20 | Can competition improve outcomes in UK health care'? Lessons from the past two decades 显示文摘 | Martin G Rodrigo M S Carol P | 2012 | Journal of Health Services Research & Policy2012，171，1： | 1 |
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