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| 1 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 2 | Immunological homologies between wheat gluten and starch granule proteins显示文摘 | Skerritt J H Frend A J Robson L G | 1990 | J Cereal Sci1990，，12： | 2 |
| 3 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 4 | Transforming growth factor beta expression in human placenta and placental bed during early pregnancy 显示文摘 | Simpson H Robson SC Bulmer JN | 2003 | Placenta2003，23，1： | 1 |
| 5 | The ultraviolet sensitivity of Kevlar 149 and teehnora fibres 显示文摘 | DOBB M G ROBSON R M ROBERTYS A H | 1993 | Journal of Materials Science1993，28，3： | 1 |
| 6 | Discussion 显示文摘 | Robson H | 1998 | Microporous and Mesoporous Materials1998，22，46： | 1 |
| 7 | The E-NTPDase family of ectonueleotidases: structure function relationships and pathophysiological significance 显示文摘 | Robson SC Sevigny J Zimmermann H | 2006 | Purinergic Signal2006，2，： | 1 |
| 8 | Thyroid hormones regulate hypertrophic chondro-cyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation显示文摘 | Stevens DA Hasserjian RP Robson H Siebler T Shalet SM Williams GR | | 0，，： | 1 |
| 9 | Natural products:potential for developing PheUodendron amurense Bark ex-tract for prostate cancer management显示文摘 | Kumar A P Graham H Robson C | 2010 | Mini Reviews inMedicinal Chemistry2010，10，5： | 1 |
| 10 | Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate显示文摘 | Siebler T Robson H Shalet SM | 2001 | Horm Res2001，56，1： | 1 |
| 11 | Altered expression of inter-leukin-6,interleukin-8 and their receptors in decidua of women withsporadic miscarriage显示文摘 | Pitman H Innes BA Robson SC e( al | 2013 | Hum Reprod2013，28，8： | 1 |
| 12 | Leaf senescence is delayed in maize expressing the Agrobacterium IPT gene under the control of a novel maize senescence-enhanced promoter 显示文摘 | ROBSON P R H DONNISON I S WANG K | 2004 | Plant Biotechnology Journal2004，，2： | 1 |
| 13 | Interactions between GH,IGF-I,glucoeorticoids,and thyroid hormones during skeletal growth显示文摘 | Robson H Siebler T Shalet SM | 2002 | Pediatr Res2002，52，： | 1 |
| 14 | Effects of interleukin-6 on extravillous trophoblast invasion in early hu- man pregnancy 显示文摘 | CHAMPION H INNES B A ROBSON S C | 2012 | Mol Hum Reprod2012，18，8： | 1 |
| 15 | Attenuation of virus diarrhea virus(strain Oregon C24V) for vaccine purposes显示文摘 | COGGINS L GILLESPIE J H ROBSON D S | 1961 | Cornell Vet1961，54，： | 1 |
| 16 | ,How to read a patent显示文摘 | Robson H | 1998 | Microporous and Mesoporous Materials1998，22，： | 1 |
| 17 | The management of rhinitis in patients with functional epiphora:a randomized controlled crossover trial显示文摘 | McNeill EJ Kubba H Bearn MA Robson AK | 2005 | Am J Rhinol2005，19，6： | 1 |
| 18 | Thyroid hormone acts di- rectly on growth platech and rocytes to promote hypertrophic differ- entiation and inhibit clonal expansion and cell proliferation 显示文摘 | Robson H Siebler T Stevens DA | 2000 | En- docrinology2000，141，10： | 1 |
| 19 | Induction of mitochondrial alternative oxidase in response to a cell signal pathway down-regnlating the cytochrome pathway prevents programmed cell death显示文摘 | VANLERBERGHE G C ROBSON C A YIP J Y H | 2002 | Plant Physiol2002，129，4： | 1 |
| 20 | Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth显示文摘 | Robson H Siebler T Shalet SM | 2002 | Pediatr Res2002，52，2： | 1 |
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