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177篇 您的检索式：作者名="Robles J M"

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	题名	作者	年代	出处	被引量
1	Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.	Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena	2007	World Journal of Gastroenterology2007，13，3：	18
2	High-throughput genetic mapping in Arabidopsos thaliana显示文摘	Ponce M R Robles P Micol J L	1999	Mol Gen Genet1999，261，：	2
3	Preparation of nuclear transplant embryos by electroporation显示文摘	Fissore R Robl J M	1993	Anal Biochemistry1993，208，1：	1
4	Relationship between nuclear remodeling and development in nuclear transplant rabbit embryos显示文摘	Collas P Robl J M	1991	Biol Reprod1991，45，：	1
5	Electrically induced calcium elevation activation and parthenogenetic development of bovine oocytes 显示文摘	COLLAS P FISSORE R ROBL J M	1993	Mol Reprod Dev1993，34，：	1
6	Production of triacylglycerols rich in palmitic acid at position 2 as intermediates for the synthesis of human milk fat substitutes by enzymatic acidolysis显示文摘	JIM(E)NEZ M J ESTEBAN L ROBLES A		0，，：	1
7	Development of mullite/zirconia composites from a mixture of aluminum dross and zircon 显示文摘	Castro M N I Robles J M A Hernndez D A C	2009	Ceramics International2009，35，2：	1
8	Prospects for the commercial cloning of animals by nuclear transplantation 显示文摘	Robl J M Stice S L	1989	Theriogenology1989，31，：	1
9	Production of triacylglycerols rich in palmitic acid at sn-2 position by lipase- catalyzed acidolysis显示文摘	Jimenez M J Esteban L Robles A	2010	Biochemical Engineering Journal2010，51，3：	1
10	Enzymatic production of human milk fat substitutes containing palmitic and docosahexaenoic acids at Sn-2 position and oleic acid at Sn-1,3 positions显示文摘	ROBLES A JIM(E)NEZ M J ESTEBAN L		0，，：	1
11	Factors activation of affecing the efficiency of nuclear transplantation in the rabbit embryo 显示文摘	COLLS P ROBL J M	1990	Biol Reprod1990，43，：	1
12	Adaptive muhiresolu- tion non-local means filter for three-dimensional magnetic resonance image denoising显示文摘	COUPE P MANJON J V ROBLES M	2012	IET Image Processing2012，6，5：	1
13	The effect protein supplements,phosphate and glucose on the in vivo development of IVM-IVF bovine oocytes显示文摘	Robl J M	1991	Theriogenology1991，35，：	1
14	Ab initio study of the reactivity and plausible polymerization process of a labdatriene monomer显示文摘	J Robles A Martinez-Richa M Villanueva	2000	Computational and Theoretical Polymer Science2000，10，6：	1
15	Transgenic animal production and animal biotechnology显示文摘	Robl J M Wang Z Kasinathan P	2007	Theriogenology2007，67，1：	1
16	An RNAi screen of the RRM-domain proteins of Trypanosoma brucei显示文摘	Wurst M Robles A Po J	2009	Mol Biochem Parasitol2009，163，1：	1
17	Stability of BacteriumMercury complexes and speciation of Soluble Inorganic Mercury Species显示文摘	ALLER A J LUMBRERAS J M ROBLES L C	1996	Anal Chim Acta1996，330，1：	1
18	Feature selection formulti-label naive Bayes classification显示文摘	Zhang M L Peia J M Robles V	2009	Information Sci- ences2009，179，19：	1
19	High-throughput genetic mapping in Arabidopsos thaliana 显示文摘	Ponce M R Robles P Micol J L	1999	Mol Gen Genet1999，261，：	1
20	Nuclear reprograrmmng in nuclear transplant rabbit embryos显示文摘	Stice S L Robl J M	1988	Biology of reproduction1988，39，3：	1

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