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423篇 您的检索式：作者名="ROBLES M"

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	题名	作者	年代	出处	被引量
1	Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.	Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena	2007	World Journal of Gastroenterology2007，13，3：	18
2	High-throughput genetic mapping in Arabidopsos thaliana显示文摘	Ponce M R Robles P Micol J L	1999	Mol Gen Genet1999，261，：	2
3	Twotone distortion in the basilar membrane of the cochlea 显示文摘	ROBLES L RUGGERO M A RICH N C	1991	Nature1991，349，：	1
4	Preparation of nuclear transplant embryos by electroporation显示文摘	Fissore R Robl J M	1993	Anal Biochemistry1993，208，1：	1
5	Specific identification of Gallibacterium by a PCR using primers targeting the 16S rRNA and 23S rRNA genes显示文摘	Bojesen A M Vazquez M E Robles F	2007	Veterinary Microbiology2007，123，：	1
6	A method for the evaluation of the fatigue operational life of submarine pressure hulls 显示文摘	Robles L B R Buelta M A Goncalves E	2000	International Journal of Fatigue2000，22，：	1
7	Relationship between nuclear remodeling and development in nuclear transplant rabbit embryos显示文摘	Collas P Robl J M	1991	Biol Reprod1991，45，：	1
8	Cytological effects of 60 Hz magnetic fields on human lymphocytes in vitro: sister-chromatid exchanges, cell kinetics and mitotic rate 显示文摘	Heredia Rojas JA Rodriguez De La Fuente AO del Roble Velazco Campos M	2001	Bioelectromagnetics2001，22，3：	1
9	yon Willebrand factorcleaving Protease in thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome 显示文摘	Furlan M Robles R Galbusera M	1998	N Engl J Med1998，339，22：	1
10	The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes : cluster randomised controlled trial( DEPICTED study) 显示文摘	ROBLING M MCNAMARA R BENNERT K	2012	BMJ2012，344，：	1
11	Keloids: pathophysiology and management显示文摘	Robles DT Moore E Draznin M	2007	Dermatol Online J2007，13，3：	1
12	Electrically induced calcium elevation activation and parthenogenetic development of bovine oocytes 显示文摘	COLLAS P FISSORE R ROBL J M	1993	Mol Reprod Dev1993，34，：	1
13	Deficient activity of vonWillebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura显示文摘	Furlan M Robles R Solenthaler M	1997	Blood1997，89，9：	1
14	Production of triacylglycerols rich in palmitic acid at position 2 as intermediates for the synthesis of human milk fat substitutes by enzymatic acidolysis显示文摘	JIM(E)NEZ M J ESTEBAN L ROBLES A		0，，：	1
15	Development of mullite/zirconia composites from a mixture of aluminum dross and zircon 显示文摘	Castro M N I Robles J M A Hernndez D A C	2009	Ceramics International2009，35，2：	1
16	Prospects for the commercial cloning of animals by nuclear transplantation 显示文摘	Robl J M Stice S L	1989	Theriogenology1989，31，：	1
17	Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis显示文摘	Furlan M Robles R Lamie B	1996	Blood1996，87，11：	1
18	Synthesis of structured lipids by two enzymatic steps:ethanolysis of fish oils and esterification of 2-monoacylglycerols显示文摘	MU(N)(I)O M M ROBLES A ESTEBAN L		0，，：	1
19	Puerto rican drugs users, esperiences of physical and sexual abuse: comparisons based on sexual identities 显示文摘	FINLINSON H A ROBLES R R COLON H M	2003	J Sex Research2003，40，3：	1
20	Ethnopharmacology of Mexican Asteraceae (Compositae)显示文摘	Heinrich M Robles M West JE Ortiz de Montellano BR Rodriguez E	1998	Annu Rev Pharmacol Toxicol1998，38，6：	1

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