|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 3 | High-throughput genetic mapping in Arabidopsos thaliana显示文摘 | Ponce M R Robles P Micol J L | 1999 | Mol Gen Genet1999，261，： | 2 |
| 4 | Preliminary studies on the cryopreservation of gilthead seabream (Sparusaurata) embryos显示文摘 | Cabrita E Robles V Wallace J C | 2006 | Aquaculture2006，25，24： | 1 |
| 5 | Preparation of nuclear transplant embryos by electroporation显示文摘 | Fissore R Robl J M | 1993 | Anal Biochemistry1993，208，1： | 1 |
| 6 | Relationship between nuclear remodeling and development in nuclear transplant rabbit embryos显示文摘 | Collas P Robl J M | 1991 | Biol Reprod1991，45，： | 1 |
| 7 | TN100: Trunked System Commutation & Transmission显示文摘 | | 1993 | 15(2):71-781993，15，2： | 1 |
| 8 | Electrically induced calcium elevation activation and parthenogenetic development of bovine oocytes 显示文摘 | COLLAS P FISSORE R ROBL J M | 1993 | Mol Reprod Dev1993，34，： | 1 |
| 9 | Methylation status of MGMT gene promoter in meningiomas 显示文摘 | de Robles P Mcintyre J Kalra S | 2008 | Cancer Genet Cytogenet2008，187，： | 1 |
| 10 | Production of triacylglycerols rich in palmitic acid at position 2 as intermediates for the synthesis of human milk fat substitutes by enzymatic acidolysis显示文摘 | JIM(E)NEZ M J ESTEBAN L ROBLES A | | 0，，： | 1 |
| 11 | Development of mullite/zirconia composites from a mixture of aluminum dross and zircon 显示文摘 | Castro M N I Robles J M A Hernndez D A C | 2009 | Ceramics International2009，35，2： | 1 |
| 12 | Prospects for the commercial cloning of animals by nuclear transplantation 显示文摘 | Robl J M Stice S L | 1989 | Theriogenology1989，31，： | 1 |
| 13 | Growth, growth velocity and adult height in Mexican girls with Turner's syndrome显示文摘 | Robles Valdes Del Castillo Ruiz V Oyoqui J | 2003 | J Pediatr Endocrinol Endocrlnol Metab2003，16，8： | 1 |
| 14 | Spanish experience in liver transplantation for hilar and peripheral cholangiocareinoma 显示文摘 | Robles R Figueras J Turrian VS | 2004 | Ann Surg2004，239，2： | 1 |
| 15 | Characteristics of coal combustion products (CCPs) from Kentucky power plants, with emphasis on mercury content显示文摘 | Hower J C Robl T L Anderson C | 2005 | Fuel2005，84，11： | 1 |
| 16 | Diterpenes from Gnaphalium pellitum and Gnaphalium graveolens显示文摘 | TORRENEGRA R PEDROZO J ROBLES J | 1992 | Phytochemistry1992，31，7： | 1 |
| 17 | Production of triacylglycerols rich in palmitic acid at sn-2 position by lipase- catalyzed acidolysis显示文摘 | Jimenez M J Esteban L Robles A | 2010 | Biochemical Engineering Journal2010，51，3： | 1 |
| 18 | Enzymatic production of human milk fat substitutes containing palmitic and docosahexaenoic acids at Sn-2 position and oleic acid at Sn-1,3 positions显示文摘 | ROBLES A JIM(E)NEZ M J ESTEBAN L | | 0，，： | 1 |
| 19 | Management of bronchiolitis in the emergency department: impact of evidence- based guidelines? 显示文摘 | Johnson L W Robles J Hudgins A | 2013 | Pediatrics2013，131，1： | 1 |
| 20 | Factors activation of affecing the efficiency of nuclear transplantation in the rabbit embryo 显示文摘 | COLLS P ROBL J M | 1990 | Biol Reprod1990，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员