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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Effectiveness of non-invasive pressure ventilation differs between decompensated chronic restrictive and obstructive pulmonary disease patients显示文摘 | Robino C Faisy C Didhl JL | 2003 | Intensive Care Med2003，29，4： | 1 |
| 3 | On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-stalding cholestasis 显示文摘 | Parola M Leonaroluzzi G Robino G | 1996 | Free Radical Biol Med1996，20，3： | 1 |
| 4 | Oxidative stress-related molecules and liver fibrosis显示文摘 | Maurizio Parola Gaia Robino | 2001 | Journal of Hepatology2001，，2： | 1 |
| 5 | Axial length in patients with diabetes 显示文摘 | Pierro L Brancato R Robino X | 1999 | Retina1999，19，5： | 1 |
| 6 | Thrombopoielin stimulates migration and activates multiple signaling pathways in hepatoblas/oma cells 显示文摘 | Romanelli RG Petrai I Robino G | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，1： | 1 |
| 7 | The stress-relief cracking suscepbility of a new ferritic steel-Part 1:single-pass heat affected zone simulations显示文摘 | NAWROCK J DUPONT J N ROBINO C V | 2000 | Welding Journal2000，79，12： | 1 |
| 8 | Axial length in patients with diabetes显示文摘 | Pierro L Brancato R Robino X | 1999 | Retina1999，19，： | 1 |
| 9 | The stress-relief crocking susceptibility of a new ferritic steel-partl : single-pass heat-affected zone simulations 显示文摘 | Nawrocki J G Dupont J N ROBINO C V | 2000 | Welding Re- search Supplement2000，，： | 1 |
| 10 | The stress-relief cracking susceptibility of a new ferritic steel-partl : multiple -pass heat-affected zone sim ulations 显示文摘 | Nawrocki J G Dupont J N Robino C V | 2001 | Welding Research Supplement2001，，： | 1 |
| 11 | The post heat-treatment response of simulated coarse-grained heat-affected zones in a new ferritic steel显示文摘 | Nawrocki J G Dupont J N Robino C V | 2001 | Metallurgical and Materials Transactions A2001，32，： | 1 |
| 12 | Intracellular bacteria in the pathogenesis of Escherichia coli urinary tract infection in children 显示文摘 | Robino L Scavone P Araujo L | 2014 | Clin Infect Dis2014，59，11： | 1 |
| 13 | Solidification and weldability of Nb-bearing superalloys 显示文摘 | Dupont J N Robino C V Marder A R | 1999 | Welding Journal1999，88，8： | 1 |
| 14 | The stress-relief cracking susceptibility of a new ~erritic steel-part 2 : multi-pass heat-affected zone simulations显示文摘 | NAWROCKI J G DUPONT J N ROBINO C V | 2001 | Welding Jour- nal2001，80，1： | 1 |
| 15 | The stress-relief cracking susceptibility of a new ferritic steel-part 1: single-pass heat-affected zone simulations 显示文摘 | NAWROCKI J G DUPONT J N ROBINO C V etal | 2000 | Welding Journal2000，79，12： | 1 |
| 16 | Development of an Italian RM Y-STR haplotype database:Results of the 2013GEFI collaborative exercise显示文摘 | ROBINO C RALF A PASINO S | 2015 | Forensic Sci Int Genet2015，15，： | 1 |
| 17 | The mechanism of stress-relief cracking in a ferritic alloy steel显示文摘 | NAWROCKI J G DUPONT J N ROBINO C V etal | 2003 | Welding Journal2003，82，2： | 1 |
| 18 | Oxidative stress-related molecules and liver fibrosis显示文摘 | Parola M Robino G | 2001 | J Heptol2001，35，2： | 1 |
| 19 | Dehydroepiandrosterone modulates nuclear factor-κB activation in hippocampus of diabetic rat显示文摘 | Mastrocola R Brignardello E Catalano M Robino G Manti R | 2002 | Endocrinology2002，143，： | 1 |
| 20 | Analysis of Y- chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample显示文摘 | Robino C Crobu F Di Gaetano C | 2008 | Int J Legal Med2008，122，： | 1 |
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