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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage显示文摘 | Cortes J Wiesmann K Roberts GA | 1995 | Science1995，268，5216： | 1 |
| 3 | Point-of-care genetic testing for person- alisat/on of antiplatelet treatment (RAPID GENE) : a prospective, randomised, proof-of-concept trial 显示文摘 | Roberts JD Wells GA le May MR | 2012 | Lancet2012，379，9827： | 1 |
| 4 | Sleep complaints and depression in an aging chart: a prospective perspective显示文摘 | Roberts RE Shema S J Kaplan GA | 2000 | Am J Psychiatry2000，157，： | 1 |
| 5 | Flower abscission in mutant tomato plants显示文摘 | TUCKER GA SCHINDLER BC ROBERTS JA | 1984 | Planta1984，160，： | 1 |
| 6 | Recombinant activated factor Ⅶ: its mechanism of action and role in the control of hemorrhage显示文摘 | Allen GA Hoffman M Roberts HR | 2002 | Can J Anaesth2002，49，： | 1 |
| 7 | The vascular endothelial growth factor family in adverse pregnancy outcomes显示文摘 | Andraweera PH Dekker GA Roberts CT | 2012 | Hum Reprod Update2012，18，4： | 1 |
| 8 | The vascular endothelial growth factor family in adverse pregnancy outcomes显示文摘 | Andraweera PH Dekker GA Roberts CT et a/ | 2012 | Hum Reprod Update2012，18，4： | 1 |
| 9 | Sleep complaints and depression in an aging cohort:A prospective perspective显示文摘 | Roberts RE Shema SJ Kaplan GA | 2000 | Am J Psychiatry2000，157，1： | 1 |
| 10 | Genetic evaluation of lipoprotein (a) in intracranial aneurysm disease显示文摘 | Corcoran BT Pfouts LL | 2001 | Neurosurgery2001，49，： | 1 |
| 11 | Are the obese at grea- ter risk for depression? 显示文摘 | Roberts RE Kaplan GA Shema SJ | 2000 | Am J Epidemiol2000，152，： | 1 |
| 12 | Genetic evaluation of lipoprotein-a intracranial aneurysm disease显示文摘 | Roberts GA Corcoran BT Pfouts LL | 2001 | Neurosurgery2001，49，： | 1 |
| 13 | Recombinant activated factor VII :its mechanism of action and role in the control of hemorrhage显示文摘 | Allen GA Hoffman M Roberts HR | 2002 | Can J Anaesth2002，，： | 1 |
| 14 | Sleep complaints and depression in an aging cohort:a prospective perspective显示文摘 | Robert RE Shema SJ Kaplan GA | 2000 | Am J Psychiatry2000，157，1： | 1 |
| 15 | Muhiplex PCR for diagnosis of AIDS-related central, nervous system lymphoma and toxoplasmosis 显示文摘 | Roberts T Storch GA | 1997 | J Clin Microbiol1997，35，1： | 1 |
| 16 | Sleep complaints and depression in an aging cohort:A prospective perspective显示文摘 | Robert RE Shema SJ Kaplan GA | 2000 | Am J Psychiatry2000，157，1： | 1 |
| 17 | Two eases of Wegener's granulomatosis involving the pituitary显示文摘 | Roberts GA Eren E Sinclair H | 1995 | Clin Endocrinol(Oxf)1995，42，： | 1 |
| 18 | Technique for monolithic fabrication of microlens array显示文摘 | Sprague Robert A Neville Connell GA | 1988 | Appl Opt1988，27，7： | 1 |
| 19 | Placebo controlled comparison of captopril, atenolol, labetolol, and pindolol in hy- pertension complicated by intermittent claudication 显示文摘 | Roberts DH Tsao Y McLoughlin GA | 1987 | Lancet1987，2，8560： | 1 |
| 20 | Novel mutations in the cellular retinaldehyde-binding protein gene (RLBP1) associated with retinitis punetata albescens: evidence of interfamilial genetic heterogeneity and fundus changes in heterozygotes显示文摘 | Fishman GA Roberts MF Derlacki D J | 2004 | Arch Ophthalmol2004，122，1： | 1 |
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