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| 1 | Mesenchymal stromal cell-based therapy: Regulatory and translational aspects in gastroenterology显示文摘The past decade has witnessed an outstanding scientific production focused towards the possible clinical applications of mesenchymal stromal cells(MSCs) in autoimmune and chronic inflammatory diseases. This raised the need of novel standards to adequately address quality, efficacy and safety issues of this advanced therapy. The development of a streamlined regulation is currently hampered by the complexity of analyzing dynamic biological entities rather than chemicals. Although numerous pieces of evidence show efficacy in reducing intestinal inflammation, some inconsistencies between the mechanisms of action of rodent vs human MSCs suggest caution before assigning translational value to preclinical studies. Preliminary evidence from clinical trials showed efficacy of MSCs in the treatment of fistulizing Crohn's disease(CD), and preparations of heterologous MSCs for CD treatment are currently tested in ongoing clinical trials. However, safety issues, especially in longterm treatment, still require solid clinical data. In this regard, standardized guidelines for appropriate dosing and methods of infusion could enhance the likelihood to predict more accurately the number of responders and the duration of remission periods. In addition, elucidating MSC mechanisms of action could lead to novel and more reliable formulations such as those derived from the MSCs themselves(e.g., supernatants). | Giovanni Dothel Emanuel Raschi Roberto Rimondini Fabrizio De Ponti | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 2 | Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing显示文摘Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed. | Laura Ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini | 2021 | Bioactive Materials2021，6，5： | 2 |
| 3 | In vivo experimental study on hone regeneration in critical hone defects using an injectable biodegradable PLA/PGA copolymer显示文摘 | Rimondini L Nicoli-Aldini N Fini M | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，99，2： | 1 |
| 4 | Contribution of CT to treatment planning in patients with GIST 显示文摘 | Rimondini A Belgrano M Favretto G | 2007 | Radiol Med2007，112，5： | 1 |
| 5 | Contribution of CT to treatment planning in patients with GIST显示文摘 | Rimondini A Belgrano M Favretto G | 2007 | Radiol Med2007，112，10： | 1 |
| 6 | Current role of color Doppler ultrasound in acute renal failure显示文摘 | Bertolotto M Quaia E Rimondini A | 2001 | Radiol Med (Torino)2001，102，56： | 1 |
| 7 | Dental implants placed in grafted maxillary sinuses: a retrospective analysis of clinical outcome according to the initial clinical situation and a proposal of defect classification显示文摘 | Chiapasco M Zaniboni M Rimondini L | 2008 | Clin Oral Implants Res2008，19，4： | 1 |
| 8 | Communication skills in psychiatry residents-how do they handle patient concerns? An application of sequence analysis to interviews with simulated patients显示文摘 | Rimondini M Del Piccolo L Goss C | | 0，，03： | 1 |
| 9 | Spiral CT with multi-planar reconstructions(MPRS)in the evaluation of ureteral neoplasms:preliminary results显示文摘 | Rimondini A Morra A Bertalotto M | 2001 | Radiol Med2001，101，6： | 1 |
| 10 | Leptin suppression of hypothalamie NPY expression and feeding, but not amygdala NPY expression and experimental anxiety 显示文摘 | Thorsell A Caberlotto L Rimondini R | 2002 | Pharmacol Binchem Behav2002，71，3： | 1 |
| 11 | Prognostic factors in nonmetastatic Ewing' s sarcoma of bone treated with adjuvant chemotherapy: Analysis of 359 patients at the Istituto Ortopedico Rizzoli 显示文摘 | Bacci G Ferrari S Bertoni F Rimondini S Longhi A Bacchini P | 2000 | J Clin Oncol2000，18，1： | 1 |
| 12 | Dental implants placed in grafted maxillary sinuses:a retrospective analysis of clinical outcome according to the initial clinical situation and a proposal of defect classification显示文摘 | Chiapasco M Zaniboni M Rimondini L | 2008 | Clin Oral Implants Res2008，19，4： | 1 |
| 13 | Adenosine AZA agonists: a potential new type of atypical antipsychotic显示文摘 | Rimondini R Ferre S Ogren SO | 1997 | Neuropsychopharma- cology1997，17，2： | 1 |
| 14 | The effect of surface roughness on early in vivo plaque colonization on titanium显示文摘 | Rimondini L Fare S Brambilla E | 1997 | J Periodontol1997，68，6： | 1 |
| 15 | Contribution of CT to treaunent planning in patients with GIST显示文摘 | Rimondini A Belgrano M Favretto G | 2007 | Radiol Med2007，112，： | 1 |
| 16 | Acetylcholine receptors containing the b2 subunit are involved in the reinforcing properties of nicotine显示文摘 | PICCIOTFOM R ZOLI M RIMONDINI R | 1998 | Nature1998，391，： | 1 |
| 17 | Contribution of CT to Treatment Planning in Patients with GIST显示文摘 | Rimondini A Belgrano M Favretto G | 2007 | Radiol Med2007，112，10： | 1 |
| 18 | Hemofiltration as short-term treatment for refractory congestive heart failure显示文摘 | Rimondini A Cipolla CM Dorf H | 1987 | Am J Med1987，，83： | 1 |
| 19 | c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region显示文摘 | Hansson AC Sommer W Rimondini R | 2003 | J Neurosci2003，23，14： | 1 |
| 20 | Radiologic evaluation in planning surgery of renal tumors显示文摘 | Pozzi-Mucelli R Rimondini A Morra A | 2004 | Abdom Imaging2004，29，3： | 1 |
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