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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 3 | Radiofrequency volumetrictissue reduction of the palate in subjects with sleep-disorderedbreathing显示文摘 | Powell N B Riley R W Troell R J | 1998 | Chest1998，113，： | 1 |
| 4 | Distributed Fault- Tolerance for Event Detection Using Heterogeneous Wireless Sensor Networks 显示文摘 | Ould-Ahmed-Vall E Heck Ferri B Riley G | 2012 | Mobile Computing IEEE Transaction on2012，11，12： | 1 |
| 5 | Comparison of postoperative pain between laser assisted uvulopalatoplasty,uvulopalatopharyngoplasty and radiofrequency volumetric tissue reduction of the palate显示文摘 | Troell T J Powell N B Riley T W | 2000 | Otolaryngol Head Neck Surg2000，122，： | 1 |
| 6 | Cobalt requirement for nodule development and function in Lupinus angustifolius 显示文摘 | Riley B T Ditworth M J | 1985 | New Physiologhist1985，100，： | 1 |
| 7 | Replication of association between schizophrenia and ZNFS04A in the Irish case-control stud- y of schizophrenia sample显示文摘 | Riley B Thiselton D Mahcr BS | 2009 | Molecular Psychiatry2009，15，： | 1 |
| 8 | Mechanism of action of Melaleuca alternifolia(tea tree) oil on Staphylococcus aureus determined by time-kill,Lysis,leakage,and salt tolerance assays and electron microscopy显示文摘 | Carson C F Mee B J Riley T V | 2002 | Antimicrob Agents Chemother2002，46，6： | 1 |
| 9 | Obstructive sleep apnea syndrome following surgery for mandibular prognathism显示文摘 | Riley R W Powell N B Guilleminault C | | 0，，5： | 1 |
| 10 | Radiofrequency volumetric reduction of the tongue显示文摘 | POWELL N B RILEY R W TROELL R J | 1997 | Chest1997，111，： | 1 |
| 11 | The determination of purines in fresh and seawater by eathodic stripping voltammetry after complexation with copper(I) 显示文摘 | Househam B C Van Den C M G Riley J P | 1987 | Analytica Chimica Acta1987，200，1： | 1 |
| 12 | Distraction osteogenesis in adult obstructive sleep apnea surgery:a preliminary report显示文摘 | Li K K Powell N B Riley R W | 2002 | J Oral Maxillofac Surg2002，60，1： | 1 |
| 13 | Mechanical proper- ties of magnesispinel composites 显示文摘 | AKSEL C RAND B RILEY F L | 2002 | J Eur Ceram Soc2002，22，5： | 1 |
| 14 | Hetastarch co-loading is as effective as pre-loading for the prevention of hypotension following spinal anesthesia for cesarean delivery显示文摘 | Carvalho B Mercier FJ Riley ET | | 0，，02： | 1 |
| 15 | Echinococcus granulosus infection in mice:host responses during primary and secondary infection显示文摘 | Riley E M Dixon J B Jenkins P | 1986 | Paeasitology1986，92，： | 1 |
| 16 | Radiofrequency tongue base reduction in sleep -disordered breathing: a pilot study显示文摘 | POWELL N B RILEY R W GUILLEMINAULT C | 1999 | Otolaryngol Head Neck Surg1999，120，： | 1 |
| 17 | The spectrophotometric deter- mination of nitrate in natural waters, with particular reference to sea-water 显示文摘 | Mullin J B Riley J P | 1955 | Analytica Chimica Acta1955，12，： | 1 |
| 18 | Building and maintaining a library Gopher:traditional skills applied to emerging resources显示文摘 | Riley R A Shipman B L | | 0，，： | 1 |
| 19 | Changes in the volatile hydrocarbon content of Prudhoe bay crude oil treated under different simulated weathering conditions 显示文摘 | Riley R G Thomas B L Anderson J W | 1980 | Marine Environmental Research1980，4，： | 1 |
| 20 | Use of the BacT/Alert blood culture system for culture of sterile body fluids other than blood显示文摘 | Bourbeau P Riley J Heiter B J | 1998 | J Clin Microbiol1998，36，11： | 1 |
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