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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 6 |
| 3 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 2 |
| 4 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | 2011 (9785)2011，，9785： | 2 |
| 5 | Governing the surgical count through communication interactions: implications for patient safety显示文摘 | RILEY R MANIAS E POLGLASE A | 2006 | Qual Saf Health Care2006，15，5： | 1 |
| 6 | Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy显示文摘 | Riley SC Crossley JA Ritoe SC Horne A Shade M Ellis PM Aitken DA Groome NP | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 7 | Observation of the autumn migration of the rice leaf roller Cnahalocrocis medinalis (Lepidoptera: Pyralidae) and other moths in eastern china 显示文摘 | Riley J R Reynolds D R Smith A D | 1995 | Bull Ent Res1995，85，： | 1 |
| 8 | The international index of erectile function(IIEF) : a multidimensional scale for assessment of erectile dysfunction显示文摘 | Rosen RC Riley A Wagner G | 1997 | Urology1997，49，6： | 1 |
| 9 | Obstetric anesthesia controversies vasopressor choice for postspinal hypotension during cesarean delivery显示文摘 | Macarthur A Riley ET | 2007 | Int Anesthesiol Clin2007，45，1： | 1 |
| 10 | Pathogenesis of virulent Newcastle disease in chickens显示文摘 | Cheville N F Riley J Ritchie A E | 1972 | J Am Vet Med Assoc1972，，： | 1 |
| 11 | The Seasat Scanning Multichannel Microwave Radiometer(SMMR):Radio-metric Calibration Algorithm Development and Perfo-rmance显示文摘 | SWANSON P RILEY A L | 1980 | IEEE Journal of Oceanic Engineering1980，5，2： | 1 |
| 12 | Genetically engineered bacteriocins and their potential as the next generation of antimierobials显示文摘 | GILLOR O NIGRO L M RILEY M A | 2005 | Current Pharmaceutical Design2005，11，： | 1 |
| 13 | The international index of erectile function(IIEF) : A multidimensional scale for assessment of erectile dysfunction显示文摘 | Rosen RC Riley A Wagner G | 1997 | Urology1997，49，6： | 1 |
| 14 | Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight显示文摘 | Riley D A Bain J L Thompson J L | 2000 | J Appl Physiol2000，88，2： | 1 |
| 15 | Rhizobium gone native:unexpected plasmid stability of indigenous Rhizobium leguminosarum显示文摘 | WERNEGREEN J J HARDING E E RILEY M A | 1997 | Proc Natl Acda Sci U S A1997，94，： | 1 |
| 16 | The international in- dex of erectile function (IIEF) : a multidimensional scale for assessment of erectile dysfunction 显示文摘 | Rosen RC Riley A Wagner G | 1997 | Urology1997，49，6： | 1 |
| 17 | Temporal changes in the prevalence of community-acquired anti- microbial-resistant urinary tract infection affected by Escherichia eoli clonal group composition显示文摘 | SMITH S P MANGES A R RILEY L W | 2008 | Clin In- feet Dis2008，46，： | 1 |
| 18 | Physical and biogeochemical controls over terrestrial ecosystem responses to nitrogen deposition显示文摘 | ASNER G P TOWNSEND A RILEY W J | 2001 | Biogeochemistry2001，54，： | 1 |
| 19 | Estimated genetic parameters for carcass traits of Brahman cattle 显示文摘 | RILEY A C CHASE C C Jr HAMMOND A C | 2002 | Journal of Animal Science2002，80，： | 1 |
| 20 | Late Jurassic macrosofossil assemblage from Jason Peninsula,Graham Land:evidence for a significant northward extension of the Latady Formation显示文摘 | RILEY T R CRAME J A THOMSON M R A | 1997 | Antartic Science1997，9，4： | 1 |
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