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69篇 您的检索式：作者名="Riddles P"

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	题名	作者	年代	出处	被引量
1	Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH.	Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle	2014	Bone Research2014，2，1：	2
2	Characterization of a gene cluster involved in bacterial degradation of the eyanobacterial toxin microcystin LR 显示文摘	Brourne D G Riddles P Jones G J	2001	Environ Toxicol2001，16，6：	1
3	Risk factors of plantar fasciitis:a matched case-control study显示文摘	Riddle DL Pulisic M Pidcoe P Johnson RE	2003	Bone Joint Surg Am2003，，5：	1
4	Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160 显示文摘	Gregory T J Riddle L	1990	Nature1990，345，：	1
5	Experiment and theory highlight role of native state topolopy in SH3 folding显示文摘	RIDDLE D S GRANTCHAROVA V P SANTIAGO J V	1999	Nat Struct Biol1999，6，11：	1
6	Modeling the impact of direct phototransformation on predicted environmental concentrations(PECs) of propranolol hydrochloride in UK and US rivers显示文摘	Robinson P F Liu Q T Riddle T	2007	Chemosphere2007，66，4：	1
7	Characterization of a gene cluster involvedin bacterial degradation of the cyanobacterial toxin microcystin LR显示文摘	Bourne D G Riddles P Jones G J	2001	Environ Toxicol2001，16，：	1
8	Risk factor for Plantar fasciitis:a matched case-control study显示文摘	Riddle D L Pulisic M Pidcoe P	2003	Bone Joint Surg Am2003，，：	1
9	A radomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes 显示文摘	Rendell M Riddle MC	2001	Diabetes Care2001，24，：	1
10	Characterization of a gene cluster involved'in bacterial degradation of the cyanobacterial toxin microcystin LR显示文摘	BOURNE D G RIDDLES P JONES G J	2001	Environ Toxico2001，，16：	1
11	A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes显示文摘	Raskin P Rendell M Riddle MC	2001	Diabetes Care2001，24，7：	1
12	Reassessment of Ellman's reagent显示文摘	Riddles P W Blakeley R L Zerner B	1983	Methods Enzymol1983，91，：	1
13	A randomized trial of rosiglitazone therapy in patients with inadequately con-trolled insulin-treated type 2 diabetes显示文摘	Rendell M Riddle MC	2001	Diabetes Care2001，24，：	1
14	Characterisati- on of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR 显示文摘	Bourne D G Riddles P Jones G J	2001	Environmen- tal Toxicology2001，16，6：	1
15	Characterization of a Gene Cluster Involved in Bacterial Degradation of the Cyanobacterial Toxin Microcystin LR 显示文摘	BOURNE D G RIDDLES P JONES G J	2001	Environ Toxicol2001，16，：	1
16	A randomized trial of nMiglita- zone therapy in patients with inadequately cnntrolled insulin- treatd type 2 diabetes显示文摘	Raskin P Rendell M Riddle MC	2001	Diabetes Care2001，24，07：	1
17	Biodegra- dation of the cyanobacterial toxin microcystin LR in natu- ral water and biologically active slow sand filters 显示文摘	Bourne D G Blakeley R L Riddles P	2006	Water Research2006，40，6：	1
18	Objective evaluation of a behavior enrichment device for captive chimpanzees(Pan troglodytes)显示文摘	Bloomstrand M Riddle K Alford P		0，，03：	1
19	Estimating the Capacity of Freight Transportation Systems: A Model and Its Application in Transport Planning and Logistics显示文摘	MORLOK E K RIDDLE S P	1999	Transportation Research Record1999，，1653：	1
20	Sensitivity to change of the Roland- Morris Back Pain Questionnaire : part 2 显示文摘	Riddle D L Stratford P W Binkley J M	1998	Phys Ther1998，78，11：	1

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