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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | A Study of electrocardiographic patterns in a population of commercial broiler chickens 显示文摘 | Olkowski A A Classen H L Riddle C | 1997 | Veterinary Research Communications1997，21，： | 2 |
| 3 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 4 | Echocardiogr aphic evaluation of the cardiovascular effects of short-duration spaceflight显示文摘 | John B Charles Jeanne M Riddle | 1991 | J Clin Pharmacol1991，31，10： | 1 |
| 5 | Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160 显示文摘 | Gregory T J Riddle L | 1990 | Nature1990，345，： | 1 |
| 6 | Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins 显示文摘 | Aiello LP Pierce EA Foley ED Takagi H Chen H Riddle L et oi | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 7 | Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa 显示文摘 | Tolar J Xia L Riddle MJ | 2011 | J Invest Dermatol2011，131，4： | 1 |
| 8 | Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation显示文摘 | JENSEN V L GALLO M RIDDLE D L | 2006 | Exp Gerontol2006，41，10： | 1 |
| 9 | Multi- tasking RGS proteins in the heart: The next therapeutic target? 显示文摘 | RIDDLE E L SCHWARTZMAN R A BOND M | 2005 | Circ Res2005，96，4： | 1 |
| 10 | Schiflett Potential contributions of rough sets data analysis to training evaluations显示文摘 | DAWN L RIDDLE MICHAEL D COOVERT LINDA R ELLIOTT etal | 2003 | Military Psychology2003，15，： | 1 |
| 11 | Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa 显示文摘 | Tolar J Xia L Riddle M J | 2011 | J Invest Dermatol2011，131，4： | 1 |
| 12 | Efficacy of glyphosate and five surfactants for controlling giant salvinia显示文摘 | Fairchild J F Allert A L Riddle J S | 2002 | J Aquat Plant Manage2002，40，： | 1 |
| 13 | Interfacial interactions between self-associated polar liquids and squalane used to test equations for solidliquid interfacial interactions显示文摘 | FOWKES F M RIDDLE F L Jr PASTORE W E | 1990 | Colloids and Surfaces1990，2，43： | 1 |
| 14 | In search of the molecular basis of heterosis显示文摘 | BIRCHLER J A AUGER D L RIDDLE N C | | 0，，： | 1 |
| 15 | New insights into the mechanism of action of amphetamines显示文摘 | Fleckenstein A E Volz T J Riddle E L | 2007 | Annu Rev Pharmacol Toxicol2007，47，： | 1 |
| 16 | Risk factor for Plantar fasciitis:a matched case-control study显示文摘 | Riddle D L Pulisic M Pidcoe P | 2003 | Bone Joint Surg Am2003，，： | 1 |
| 17 | Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins显示文摘 | Aiello LP Pierce EA Foley ED Takagi H Chen H Riddle L | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 18 | Enzyme leaching of surficial geochemical samples for defecting hydromorphic trace-element anomalies associated with precious-metal mineralized bedrock buried beneath glacial overburden in northern Minnesota显示文摘 | Clark J R Meier A L and Riddle | 1990 | In: GOLD'' 901990，，： | 1 |
| 19 | Reassessment of Ellman's reagent显示文摘 | Riddles P W Blakeley R L Zerner B | 1983 | Methods Enzymol1983，91，： | 1 |
| 20 | Contri-butions of descending and ascending pathways to corticomus-cular coherence in humans 显示文摘 | WITHAM C L RIDDLE C N BAKER M R | 2011 | J Physiol2011，589，15： | 1 |
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