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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | ACCORD试验中的血糖治疗方案显示文摘高血糖与心血管疾病(CVD)之间存在独立的流行病学递增关系,然而,以当前应用的疗法降低血糖水平是否可降低CVD事件发生率仍不明确。ACCORD试验被设计用于解决2型糖尿病高危患者中的这一问题。ACCORD试验中。 | Gerstein H.C. Riddle M.C. Kendall D.M. 马超 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 3 |
| 3 | DGGE fingerprinting of bacteria in soils from eight ecologically different sites around Casey Station, Antarctica显示文摘 | C. W. Chong G. Y. Annie Tan Richard C. S. Wong Martin J. Riddle Irene K. P. Tan | 2009 | Polar Biology2009，，6： | 2 |
| 4 | A Study of electrocardiographic patterns in a population of commercial broiler chickens 显示文摘 | Olkowski A A Classen H L Riddle C | 1997 | Veterinary Research Communications1997，21，： | 2 |
| 5 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 6 | The Yale Global Tic Severity Scale:initial testing of a clinician-rated scale of tic severity显示文摘 | Leckman JF Riddle MA Hardin MT | 1989 | J Am Acad Child Adolesc Psychiatry1989，28，4： | 1 |
| 7 | Role of monoamine transporters in mediating psychostimulant effects显示文摘 | Riddle EL Fleckenstein AE Hanson GR | 2005 | AAPS J2005，7，4： | 1 |
| 8 | The treat to target trial :randomized addition Of glargine or humaⅡ NPH insulin to oral therapy of type 2diabetic patients 显示文摘 | Riddle MC Rosenstoek J Gerieh J | 2003 | Diabetes Care2003，26，11： | 1 |
| 9 | Comparisons between FLUENT and ADMS for atmospheric dispersion modeling显示文摘 | RIDDLE A CARRUTHERS D SHARPE A | 2004 | Atmospheric Environment2004，38，7： | 1 |
| 10 | Characterization of a gene cluster involved in bacterial degradation of the eyanobacterial toxin microcystin LR 显示文摘 | Brourne D G Riddles P Jones G J | 2001 | Environ Toxicol2001，16，6： | 1 |
| 11 | The Yale Global Tic Severity Scale: initial testing of a clini- cian-rated scale of tic severity 显示文摘 | Leckman JK Riddle MA Hardin MT | 1989 | J Am Acad Child Adolesc Psychiatry1989，28，4： | 1 |
| 12 | Maturation-dependent vulnerability of perinatal white matter in premature birth 显示文摘 | Back S A Riddle A McClure M M | 2007 | Stroke2007，38，2： | 1 |
| 13 | The chronic gastrointestinal consequences associated with campylobacter 显示文摘 | Riddle MS Gutierrez RL Verdu EF | 2012 | Curr Gastroenterol Rep2012，14，： | 1 |
| 14 | Theory of stagnation point heat transfer in dissociated air显示文摘 | Fay J A Riddle F R | 1985 | Journal of the Aeronautical Science1985，25，2： | 1 |
| 15 | Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes 显示文摘 | Janka HU Plewe G Riddle MC | 2005 | Diabetes Care2005，28，2： | 1 |
| 16 | Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images 显示文摘 | Peterson B Riddle MA Cohen DJ | 1993 | Neurology1993，43，5： | 1 |
| 17 | Impact of demographic and impairment-related variables on disability associated with plantar fasciitis显示文摘 | Riddle DL Pulisic M Sparrow K | | 0，，05： | 1 |
| 18 | Maturation-dependent vulnerability of perinatal white matter in premature birth显示文摘 | Back SA Riddle A McClure MM | | 0，，： | 1 |
| 19 | Risk factors of plantar fasciitis:a matched case-control study显示文摘 | Riddle DL Pulisic M Pidcoe P Johnson RE | 2003 | Bone Joint Surg Am2003，，5： | 1 |
| 20 | Combined therapy with insulin plus oral agents: is there any advantage? An argument in favor显示文摘 | Riddle MC | 2008 | Diabetes Care2008，31，2： | 1 |
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