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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 3 | Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum 显示文摘 | Gookin J L Rhoads J M Argenzio R A | 2002 | American Journal of Physiology-Gastrointes- tinal and Liver Physiology2002，283，1： | 1 |
| 4 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P BURGE C B BARTEL B BARTEL D P | 2002 | Cell2002，110，4： | 1 |
| 5 | Genetic diversity of cultured Penaeus vannamei shrimp using three molecular genetic techniques显示文摘 | Garcia D K Faggart M A Rhoades L | 1994 | Molecular Mar Biol Biotecn1994，3，5： | 1 |
| 6 | The microRNAs of Caenorhabditiselegans显示文摘 | Lim L Lau N Weinstein E Abdelhakim A Yekta S Rhoades M Burge C Bartel D | 2003 | Genes & Dev2003，，： | 1 |
| 7 | Pre- diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 8 | Geneticdiversity of cultured Penaeus vannamei shrimp using three molecu-lar genetic techniques显示文摘 | GARCIA D K FAGGART M A RHOADES L | 1994 | Mol Mar Biol Biotechnol1994，3，5： | 1 |
| 9 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lira L P | 2002 | Cell2002，110，4： | 1 |
| 10 | Salicylic acid regulation of respiration in higher plants:alternative oxidase expression显示文摘 | RHOADS D M MCINTOSH L | 1992 | Plant Cell1992，4，9： | 1 |
| 11 | Genetic diversity of cultured Penaeus vannamei shrimp using three molecular genetic techniques显示文摘 | Garcia D K Faggart M A Rhoades L | 1994 | Molecular Mar Biotechm1994，3，5： | 1 |
| 12 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P | 2002 | Cell2002，110，4： | 1 |
| 13 | Pre diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，： | 1 |
| 14 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 15 | Salicylic acid regulation of respiration inhigher plants:alternative oxidase expression显示文摘 | RHOADS D M MCINTOSH L | 1992 | The Plant Cell Online1992，4，9： | 1 |
| 16 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 17 | An Analysis of Default Risk in Mobile Home Credit 显示文摘 | Lawrence E L Smith S Rhoades M | 1992 | Journal of Banking & Finance1992，，16： | 1 |
| 18 | Growth hormone receptor,insulin-like growth factor(IGF)-Ⅰ,and IGF-binding protein-2 expression in the reproductive tissues of early postpartum dairy cows显示文摘 | Rhoads M L Meyer J P Kolath S J | | 0，，05： | 1 |
| 19 | Prediction of plant mieroRNA targets显示文摘 | Rhoades M W Reinhart B J Lira L P | 2002 | Cell2002，110，4： | 1 |
| 20 | Prediction of plant mieroRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Ce112002，110，4： | 1 |
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