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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 3 | IL-4 downregulates IL-1 and TNF gene expression in human monocytes显示文摘 | Essner R Rhoades K McBride WH | 1989 | J Immunol1989，142，11： | 1 |
| 4 | A role for HOX A5 in regulating angiogenesis and vascular patterning显示文摘 | Rhoads K Arderiu G Charboneau A | 2005 | Lymphat Res Biol2005，3，4： | 1 |
| 5 | Antecedents and Consequences of Burnout in Accounting:Beyond the Role Stress Model 显示文摘 | Fogarty T J Singh C Rhoads R K Moore | 2000 | Behavioral Research in Accounting2000，12，： | 1 |
| 6 | Does ambient air pollution trigger stillbirth?显示文摘 | Faiz AS Rhoads GG Demissie K | 2013 | Epidemiology2013，24，4： | 1 |
| 7 | a new capsule serogroup of Pasreurellu mullocida显示文摘 | Rimler R B Rhoades K R Serogroup F | 1987 | Clin Microbiol1987，25，： | 1 |
| 8 | Serologic types and physiologic characteristics of 46 avian Pasteurella anatipestifer eultures显示文摘 | Brogden K A Rhoades K R Rimler R B | 1982 | Avian Disease1982，26，4： | 1 |
| 9 | Does ambient air pollution trigger stillbirth? 显示文摘 | Faiz AS Rhoads GG Demissie K | 2013 | Epidemiology2013，24，4： | 1 |
| 10 | Genetic diversity of cultured Penaeus vannamei shrimp using three molecular genetic techniques显示文摘 | Garcia D K Faggart M A Rhoades L | 1994 | Molecular Mar Biol Biotecn1994，3，5： | 1 |
| 11 | Fowl cholera:Cross-protection induced by Pasteurella multocida separated from infected turkey blood显示文摘 | Rimler R B Rebers P A Rhoades K R | 1979 | Avian Dis1979，23，： | 1 |
| 12 | Geneticdiversity of cultured Penaeus vannamei shrimp using three molecu-lar genetic techniques显示文摘 | GARCIA D K FAGGART M A RHOADES L | 1994 | Mol Mar Biol Biotechnol1994，3，5： | 1 |
| 13 | Oligosaccharide - mediated inhibition of the adhesion of pathogenic Eseheriehia coil strains to human gut epithelial cells in vitro 显示文摘 | Rhoades J Manderson K Wells A Hotchkiss AT Gibson GR Formentin K Beer M Rastall RA | 2008 | Journal of Food Protection2008，71，11： | 1 |
| 14 | Modulation of cross-protection factors of avian Pasteurella multocida显示文摘 | Rimler R B Rebers P A Rhoades K R | 1979 | Avian Dis1979，23，： | 1 |
| 15 | Electro-optic charge injection and tramsport measurements in highly purified water and water/ethylene glycol mixtures显示文摘 | Zahn M Ohki Y Rhoads K | 1985 | IEEE Transactions on Electrical Insulation1985，20，2： | 1 |
| 16 | Conjugal transfer of an R-plasmid in Pasteurella multocida显示文摘 | Hirsh D C Martin L D Rhoades K R | 1981 | Antimicrob AgentsChemother1981，20，3： | 1 |
| 17 | Genetic diversity of cultured Penaeus vannamei shrimp using three molecular genetic techniques显示文摘 | Garcia D K Faggart M A Rhoades L | 1994 | Molecular Mar Biotechm1994，3，5： | 1 |
| 18 | Novel business models and radical technologies under capital con- straints: Complements or liabilities?显示文摘 | Rhoads K Townsend D Busenitz L | 2011 | Frontiers of En- trepreneurship Research2011，31，12： | 1 |
| 19 | Solubilizadon of membraneassociated cross-protection factor (s)of Pasteurella multoeida显示文摘 | Rimler R B Rhoades K R | 1989 | Avian Dis1989，33，： | 1 |
| 20 | Antecedents and Consequences of Burnout in Accounting:Beyond the Role Stress Model显示文摘 | Fogarty T J Singh J Rhoads G K | 2000 | Behav Res Account2000，12，： | 1 |
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