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| 1 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 4 | Effect of pH on saturated hydraulic conductivity and soil dispersion显示文摘 | Suarez D L Rhoades J D Savado R | 1984 | Soil Sci Soc Am J1984，，48： | 1 |
| 5 | Potyviral proteins share amino acid sequence homology with picorna-, como-, and caulimo viral proteins 显示文摘 | Domier L L Shaw J G Rhoads R E | 1987 | Virology1987，158，： | 1 |
| 6 | Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum 显示文摘 | Gookin J L Rhoads J M Argenzio R A | 2002 | American Journal of Physiology-Gastrointes- tinal and Liver Physiology2002，283，1： | 1 |
| 7 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P BURGE C B BARTEL B BARTEL D P | 2002 | Cell2002，110，4： | 1 |
| 8 | Extrude hone abrasive flow machining : adecade of progress 显示文摘 | RHOADES L J | 1980 | Abrasive Engineering SocietyMagazine1980，14，5： | 1 |
| 9 | Pre- diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 10 | Leaching requirement for soil salinity control: Steady-state versus transient mod- els显示文摘 | Corwin D L Rhoades J D Simunek J | 2007 | Agricultural Water Management2007，90，3： | 1 |
| 11 | Prediction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lira L P | 2002 | Cell2002，110，4： | 1 |
| 12 | Effect of rock stress on gas production from low-permeability from res- ervoirs显示文摘 | Vairogs J Hearn C L Dareing D W Rhoades V W | 1971 | Journal of Petroleum Technology1971，9，： | 1 |
| 13 | Prediction of plant microRNA targets显示文摘 | RHOADES M W REINHART B J LIM L P | 2002 | Cell2002，110，4： | 1 |
| 14 | Pre diction of plant microRNA targets显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，： | 1 |
| 15 | Measurement of inverted electrical conductivity profiles using electromagnetic induction显示文摘 | Corwin D L Rhoades J D | 1984 | Soil Science Society of America1984，48，： | 1 |
| 16 | Potyviral proteins share amino acid sequence homology with pi- corn-, como-, and caulimo-viral proteins显示文摘 | Domier L L Shaw J G Rhoads R E | 1987 | Virology1987，158，11： | 1 |
| 17 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 18 | Does pay for performance increase or decrease perceived self - determination and intrinsic motivation? 显示文摘 | EISENBERGER R RHOADES L CAMERON J | 1999 | Journal of Personality and Social Psychology1999，77，： | 1 |
| 19 | Abrasive Flow Machining:a Case Study显示文摘 | Rhoads L J | 1991 | Journal of Materials Processing Technology1991，28，2： | 1 |
| 20 | Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress显示文摘 | Rhoads R P Baumgard L H Suagee J K | 2013 | Advances in Nutrition2013，，3： | 1 |
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