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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 3 | Fenton and photo-Fenton oxidation of textile effluents显示文摘 | Péreza M Torradesa F Domenechb X | 2002 | Water Research2002，36，： | 1 |
| 4 | Application of MM5 and CAMx4 to local scale dispersion of particulate matter for the city of Christchurch, New Zealand 显示文摘 | Titov M Sturman A P Zawar- Reza P | 2007 | At- mospheric Environment2007，41，： | 1 |
| 5 | Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis显示文摘 | Suárez-SantamaríaM SantolariaF Pérez-RamírezA | 2010 | Eur Cytokine Netw2010，21，1： | 1 |
| 6 | Glow- discharge treated piezoelectric quartz crystals as immumo - sensors for HSA detection显示文摘 | Reza S Selma M Erhan P | 2002 | Biosensors and Bioelectronics2002，17，： | 1 |
| 7 | Improvement of pre- dicted fine and total particulate matter (PM) composition by applying several different chemical seenarios:A winter 2005 case study 显示文摘 | Titov M Sturman A Zawar - Reza P | 2007 | Science of the Total Environment2007，385，： | 1 |
| 8 | Water and pollution discharge permit allocation to agricultural zones:application of game theory and min-max regret analysis显示文摘 | Hamed P S Reza K Mohammad R N | 2012 | Water Resources Management2012，26，14： | 1 |
| 9 | The effects of dietary protein and lysine levels on broiler performance,carcass characteristics and N excretion显示文摘 | Rezaei M Moghaddam H N Reza J P | 2004 | International Journal of Poultry Science2004，2，： | 1 |
| 10 | CUDA Implementation of FDTD Solution of Maxwell's Equations in Dispersive Media显示文摘 | Mohammad Reza Zunoubi Jason Payne William P Roach | | 0，，1536： | 1 |
| 11 | Separation of 1-lysine from dilute aqueous solution using molecular imprinting technique显示文摘 | Reza P Ebrahim V F Seyed A S | 2007 | Biochemical Engineering Journal2007，，35： | 1 |
| 12 | The effects of nanoscale expansive agents on the mechanical properties of non-shrink cement-based composites:the influence of nano-MgO addition显示文摘 | Reza M Ehsan T N Tayebeh P | 2013 | Composites:Part B2013，55，： | 1 |
| 13 | Solving a multi-objective open shop scheduling problem by a novel hybrid ant colony optimization显示文摘 | HADI P REZA T M | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 14 | Effect of emulsifier and guar gum on micro structural,rheological and baking performance of frozen bread dough显示文摘 | P D Ribottaa G T Péreza A E Leóna M C Anónb | 2004 | Food Hydrocolloids2004，18，： | 1 |
| 15 | The effects of dietary protein and lysine levels on broiler performance,carcass characteristics and N excretion显示文摘 | Rezaei M Moghaddam H N Reza J P | 2004 | Int J Poult Sci2004，3，2： | 1 |
| 16 | Realiability and failure analyses of thermal cycled ball grid array assemblies 显示文摘 | Reza Ghaffarian Namsoo P kim | 2000 | IEEE transactions on components and packaging technologies2000，23，3： | 1 |
| 17 | Characterization of surface-breaking cracks using one tangential component of magnetic leakage field measurements显示文摘 | Reza Khalaj Amineh Natalia K Nikolova James P Reilly | 2008 | IEEE Transactions on Magnetics2008，44，4： | 1 |
| 18 | Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue 显示文摘 | REZA I CYNTHIA T BINDIYA P | 2006 | J Cell Biochem2006，99，： | 1 |
| 19 | Ultrahigh purcell factors and lamb shifts in slow-light metamaterial waveguides显示文摘 | Yao P J Vlack C V Reza A | | 0，，： | 1 |
| 20 | A two-dimensional flow model for the process simulation of complex shape composite laminates 显示文摘 | Hubert P Reza V Anoush P | 1999 | International Journal of Numerical Mathematic Engineer1999，44，1： | 1 |
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