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| 1 | Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma显示文摘AIM: To study the implication of prokineticin 1 (PK1/EG- VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. METHODS: The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR. Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an endothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry. RESULTS: PK2/Bv8 mRNA but not PK1/EG-VEGF was expressed in all types of normal liver samples examined. In the context of liver tumor development, we reported that PK2/Bv8 correlates only with CD68 and showed a significant decrease in expression as the pathology evolves towards cancer. Whereas, VEGF and vWF mRNA were significantly upregulated in both fibrosis and HCC,as expected. In addition, out of all isolated liver cells examined, only Kupffer cells (liver resident macrophages) express significant levels of PK2/Bv8 and its receptors, prokineticin receptor 1 and 2. CONCLUSION: In normal liver PK2/Bv8 and its receptors were specifically expressed by Kupffer cells. PK2/Bv8 expression decreased as the liver evolves towards cancer and did not correlate with HCC angiogenesis. | Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clément Bruno Turlin Nathalie Théret Michel Samson | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 2 | CO2加氢催化剂Cu/ZrO2/SiO2上Zr(IV)表面位对甲醇生成速率的影响(英文)显示文摘Cu/ZrO2/SiO2是有效的CO2选择加氢制甲醇催化剂.为了理解混合氧化物基催化剂中ZrO2的作用,在Cu和Zr的K边进行了原位X-射线吸收光谱测试.在反应条件下, Cu保持金属态,而Zr以三类配位环境的形式存在:体相ZrO2,配位饱和的、以及不饱和的Zr(Ⅳ)表面位.配位不饱和Zr表面位可通过线性拟合参比的X射线吸收近边结构光谱进行定量,发现其数量与甲醇生成速率有关,因而表明Zr(Ⅳ)Lewis酸表面位在驱动选择生成甲醇反应中的重要性.这与提出的机理是一致的:在裂解H2的Cu纳米颗粒与稳定反应中间体的Zr(Ⅳ)表面位之间的界面上进行CO2加氢. | Erwin Lam Kim Larmier Shohei Tada Patrick Wolf Olga V. Safonova Christophe Copéret | 2019 | Chinese Journal of Catalysis2019，40，11： | 2 |
| 3 | BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation显示文摘 | Retting KN Song B Yoon BS | 2009 | Development2009，136，7： | 1 |
| 4 | Rickets Caused by Vitamin D deficiency in breastfed infants in the Southern United States显示文摘 | Bhowmick SK Johnson KR Retting KR | 1991 | AJDC1991，145，： | 1 |
| 5 | Iatrogenic ureteral lesions and repair: A review forgynecologists 显示文摘 | DE CICCO C RET DA VALOS M L VAN CLEYNENBREUGEL B | 2007 | J Minim Invasive Gynecol2007，14，4： | 1 |
| 6 | miRNA signature as- sociated with outcome of gastric cancer patients following chemotherapy 显示文摘 | Kim CH Kim HK Retting RL | 2011 | BMC Med Genomics2011，4，11： | 1 |
| 7 | The value of the world's ecosystem services and natural capital显示文摘 | d' ArgeR de Groot Ret al | 1997 | Nature1997，387，： | 1 |
| 8 | Optimal therapeutic strategies in ovarian epithelial cancer in 1997显示文摘 | Piccart MJ Noga ret JM | 1997 | Rev Med Brus1997，18，： | 1 |
| 9 | Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantation显示文摘 | Patel AM Cahill LD Ret J | 2007 | Arch Otolaryngol Head Neck Surg2007，133，7： | 1 |
| 10 | Open reduction and internal fixation of acute displaced scaphoid waise fractures显示文摘 | Retting ME Kozin SH Coeney WP | 2002 | J Hand Surg (Am)2002，26，2： | 1 |
| 11 | Influence Signal Timing on Red Light Running and Potential Vehicle Conflicts at Urban Intersections显示文摘 | Retting R A Greene M A | 1997 | Transportation Research Record1997，，1595： | 1 |
| 12 | Interactions between the sympathetic nervous sys- tem and the kidneys in arterial hypertension 显示文摘 | Grisk O Retting R | 2004 | Cardiovasec Res2004，61，2： | 1 |
| 13 | Validity of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy:a multicentre European study显示文摘 | Rajabally YA Nicolas G Piéret F | 2009 | J Neurol Neurosurg Psychiatry2009，80，12： | 1 |
| 14 | Red Light Running and Sensible Countermeasures:Summary of Research Finding显示文摘 | Retting R A Williams A F Greene M A | 1998 | Transportation Research Record1998，，1640： | 1 |
| 15 | Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I显示文摘 | Ei MM Nogueira V Fontaine E Avéret N Rigoulet M Leverve X | 2000 | J Biol Chem2000，275，1： | 1 |
| 16 | Sulfur isotope fraction- ation during bacterial reduction and disproportionation of thiosul- fate and sulfite 显示文摘 | Habicht K Canfield D E Ret hemeier J | 1998 | Geochimica et Cosmochimica Acta1998，62，15： | 1 |
| 17 | Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock显示文摘 | Jordan E T Williams N J Watt ret A | 2005 | Vet Rec2005，157，19： | 1 |
| 18 | Comparison of Real-Time Three-Dimensional Speckle Tracking to Magnetic Resonance Imaging in Patients With Coronary Heart Disease显示文摘 | Delphine Hayat Martin Kloeckner Julien Nahum Emmanuelle Ecochard-Dugelay Jean-Luc Dubois-Randé Deux Jean-Fran?ois Pascal Guéret Pascal Lim | 2012 | The American Journal of Cardiology2012，，2： | 1 |
| 19 | Simple clinicalpredictors may obviate urgent endoscopy in selected patientswith nonvariceal upper gastrointestinal tract bleeding显示文摘 | Romagnuolo J Barkun A N Enns Ret a l | 2007 | Arch Intern M ed2007，167，3： | 1 |
| 20 | Expression of P21 in normed and malignant human tissues, Lack of association with proliferation and malignaney显示文摘 | Retting W J Melaned M R | 1987 | Prol Natl Acad Sci USA1987，84，： | 1 |
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