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| 1 | Current global trends in the incidence of pediatric-onset inflammatory bowel disease显示文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts. | Josef Sykora Renta Pomahacov Marcela Kreslová Dominika Cvalínová Premysl Stych Jan Schwarz | 2018 | World Journal of Gastroenterology2018，24，25： | 27 |
| 2 | The Armed Services Blood Program: blood support to combat casulty care 2001 to 2011显示文摘 | Rentas E Lincoln D Harding A | 2012 | Trauma Acute Care Surg2012，73，65： | 1 |
| 3 | Inactivation of Orientia tsutsugamushi in red blood cells, plasma and platelets with riboflavin and light, as demonstrated in an animal model 显示文摘 | Rentas F Harman R Gomez C | 2007 | Transfusion2007，47，2： | 1 |
| 4 | Pathogen in- activation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultravi- olet light显示文摘 | Cardo LJ Rentas FJ Ketchum L | 2006 | Vox Sang2006，90，1： | 1 |
| 5 | Pathogen inactivation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light显示文摘 | Cardo LJ Rentas FJ Ketchum L | 2006 | Vox Sang2006，90，2： | 1 |
| 6 | Evidence of Trypanosoma cruzi infection (Chaga's disease) among patients undergoing cardiac surgery显示文摘 | Leiby DA Rentas FJ Nelson KE | 2000 | Circulation2000，102，24： | 1 |
| 7 | New insulation techunology provides next- generation containers for 'ieeIess' and lightweight transport of RBCs at I to 10 ℃in extreme tempera- tures for over 78 hours显示文摘 | RENTAS F J MACDONALD V W HOUCHENS D M | 2004 | Transfusion2004，44，： | 1 |
| 8 | Pathogen inactivation of Leishmania donovani infantum in plasma and platelet concentrates using riboflavin and ultraviolet light 显示文摘 | Cardo LJ Rentas FJ Ketchum L | 2006 | Vox Sang2006，90，2： | 1 |
| 9 | The armed services blood program:blood support to combat casualty care 2001 to 2011显示文摘 | Rentas F Lincoln D Harding A | | 0，，6： | 1 |
| 10 | RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfoldedprotein response pathway 显示文摘 | Ray A Zhang S Rentas C | 2014 | J Neurosci2014，34，16： | 1 |
| 11 | New method for isolation of immunologically pure pili from Escherichia coli显示文摘 | Korhonen T K Nurmiaho E L Renta H | 1980 | Infect Immun1980，27，： | 1 |
| 12 | New insulation technology provides next-generation containers for ' iceless' and lightweight transport of RBCs at 1 - 10℃ in extreme tempretures for over 78 hour显示文摘 | Rentas FJ Macdonald VW Houehens DM | 2004 | Transfusion2004，44，2： | 1 |
| 13 | New insulation technology provides next-generation containers for 'iceless' and lightweight transport of RBCs at 1 to 10℃ in extreme temperatures for over 78 hours显示文摘 | Rentas FJ Macdonald VW Houchens DM | | 0，，01： | 1 |
| 14 | The armed services blood program:blood support to combat casualty care 2001 to 2011显示文摘 | Rentas F Lincoln D Harding A | 2012 | J Trauma Acute Care Surg2012，73，： | 1 |
| 15 | The armed services blood program: blood support to combat casualty care 2001 to 2011显示文摘 | Rentas F Lincoln D Harding A | 2012 | J Trauma Acute Care Surg2012，73，65： | 1 |
| 16 | Constant challenges and evolution of US mili- tary transfusion medicine and blood operations in combat 显示文摘 | Spinella PC Dunne J Bielman GJ O'Connell ILl Borgman MA Cap AP Rentas F | 2012 | Transfusion2012，，52： | 1 |
| 17 | New insulation techunology provides next - generation containers for 'iceless' and lightweight transport of RBCs at 1 to 10 C in ex- treme temperatures for over 78 hours 显示文摘 | RENTAS F J MACDONALD V W HOUCHENS D M | 2004 | Transfusion2004，44，2： | 1 |
| 18 | Uric acid improves glucose-driven oxidative stress in human ischemic stroke显示文摘 | Amaro S Llull L Renta A | 2015 | Ann Neurol2015，77，： | 1 |
| 19 | The Armed Services Blood Program: blood support to combat casualty care 2001 to 2011 显示文摘 | Rentas F Lincoln D Harding A | 2012 | J Trauma Acute Care Surg2012，73，65： | 1 |
| 20 | Generation of superoxide anion and induction of superoxide dismutase and peroxidase in bean beaves infected with pathogenic fungi显示文摘 | Urbanek Henryh Ewa Gajewska Renta kavwowska and Marzena Wielanek | 1997 | Acta Biochemica Polonica1997，43，4： | 1 |
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