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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Methods for the development and assessment of atrial fibrillation and heart failure dog models显示文摘与动物的发展报导 Medtronic 经验的目的用为 AF 模型,的为 CHF.Methods 的为 AF 和 microemboli 的高率的踱步为 atrial 纤维性颤动( AF )和长期的心失败( CHF )当模特儿一根 atrial 皮带被纳入 Medtronic 协同作用 neurostimulator ,它被规划在开关责任 cycle.Atrial natnuretic 肽( ANP )在 50 Hz 刺激,大脑 natriuretic 肽( BNP )和N终端职业人员大脑 natriuretic 肽( NT-proBNP )皮脂腺囊瘤;在精选时间 points.For CHF 模型,的 assayed 在 62,400 beads/mL 的 90 m 聚苯乙烯 microspheres 的连续注射( Polybead , Polysciences 公司)被执行导致全球局部缺血,有每周监视的任何一个和 embolization 时间表(集团 1 , n = 25 )或与监视的双周刊和 emboliation 时间表(集团 2 , n36 ) .Echocardiograms 每周与 ventriculograms 和磁性的回声成像扫描一起被使用估计心脏的功能和 ANP , BNP 和 NT-proBNP 是为 AF 模型的 monitored.Results ,为 CHF 模型,遇见 CHF 端点的日子在集团 2 .For 在集团 1 和 89 是 116 AF 和 CHF 模型, NT-proBNP 与在为动物的搜索的研究人员为估计基于设备的治疗的安全和功效建模的我们为 AF 和 CHF 狗模型的发展和评价的经验可以帮助的疾病 states.Conclusion 的发展相关很好。 | Jon F Urban Renee L Gerhart Jason R Krzeszak Corey R Leet Linnea R Lentz Carolyn B McClay | 2011 | Journal of Geriatric Cardiology2011，8，3： | 3 |
| 3 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 4 | Anti-Hu antibodies in patients with small-cell lung cancer:association with complete response to therapy and improved survival显示文摘 | Dalmou J Rene R | 1997 | J Clin Oncol1997，15，8： | 1 |
| 5 | RAPD variation among and within small and large populations of the rare clonal plant Ranunculm reptans(Ranuneulaeeae ) 显示文摘 | MARKUS F RENE H DANIEL P | 2000 | American Journal of Botany2000，87，： | 1 |
| 6 | Two-dimensional current percolation in nanocrystalline vana- dium dioxide films 显示文摘 | Rozen John Lopez Rene Haglund R F | 2006 | Applied Physics Letters2006，88，08： | 1 |
| 7 | Assess-ment methods used in texas public schools for the diagnosisof pervasive developmental disorders in children: a survey显示文摘 | Jeff F Maria Diana Gonzales Renee Wendel ^ al | 2009 | Texas journal of Audiology and Speech-LanguagePathdogy2009，2010，： | 1 |
| 8 | Identification of patients with high-risk lymph node-negative colorectal cancer and potential benefit from adjuvant chemotherapy显示文摘 | Luis F Onate O Rene M | 2004 | Jpn J Clin Oncol2004，34，： | 1 |
| 9 | A note on the freeze- drying conditions for improved aroma retention in cultivated mushrooms 显示文摘 | E Kompany F Rene | 1995 | Lebensm-Wiss u-Technol1995，28，： | 1 |
| 10 | Identification of patients with high-risk lymph node-negative colorectal cancer and potential benefit from adjuvant chemotherapy显示文摘 | LUIS F ONATE O RENE M | 2004 | Jpn J Clin Oncol2004，34，6： | 1 |
| 11 | Proteomic analysis of log to stationary growth phase Lactobacillus plantarum cells and a 2-DE database显示文摘 | COHEN D P A RENES J BOUWMAN F G | | 0，，： | 1 |
| 12 | Minimization of Torque Ripple in Brushless DC Motor Drives显示文摘 | Hoang L H Robert P Rene F | 1986 | IEEE Transactions on Industry Application1986，22，4： | 1 |
| 13 | Up-regulation of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis显示文摘 | Dupuis L di Scala F Rene F | | 0，，14： | 1 |
| 14 | Identification of patients with high-risk lymph node-negative colorectal cancer and potential benefit from adjuvant chemotherapy 显示文摘 | Luis F Onate O Rene M | 2004 | Jpn J Clin Oncol2004，34，6： | 1 |
| 15 | Up-regulation Of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis显示文摘 | Dupuis L di Scala F Rene F | 2003 | FASEB J2003，17，14： | 1 |
| 16 | Prognostic significance of type IV collagen and immunoreaetity IV inurothellal carcinoma of the bladder显示文摘 | RENE F M RUND P MICHAEL G | 1990 | Cancer J1990，12，： | 1 |
| 17 | Absence of an adipogenic effect of rosiglitazone on mature 3T3-L1 adipocytes:increase of lipid catabolism and reduction of adipokine expression显示文摘 | P Wang J Renes F Bouwman | 2007 | Diabetologia2007，50，： | 1 |
| 18 | The silence of the genes显示文摘 | Ronald HA Plasterk Rene F Ketting | 2000 | Current Opinoin in Genetics & Development2000，，10： | 1 |
| 19 | Anti-Hu-associated paraneoplastic encephalomyelitis:analysis of 200 patients显示文摘 | Graus F Keime-Guibert F Rene R | 2001 | Brain2001，124，6： | 1 |
| 20 | Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells显示文摘 | Van-Summeren A Renes J Bouwman F G | 2011 | Toxicol Sci2011，120，1： | 1 |
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