|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 基于精密单点定位技术的航空测量应用实践显示文摘讨论了基于精密单点定位技术来实现无地面基准站的航空测量。计算结果表明,用观测值的验后残差计算得到的实测动态及静态模拟动态进行精密单点定位的三维RMS均优于3 cm;用动态数据精密单点定位的结果同多基准站的双差解求较差计算出的RMS,南北分量和东西分量均优于5 cm,高程分量优于10cm;用基准站的静态数据模拟动态单点定位解算得到的坐标同已知坐标求较差计算出的RMS,南北分量和东西分量均优于3 cm,高程分量优于5 cm。 | 张小红 刘经南 Rene Forsberg | 2006 | 武汉大学学报(信息科学版)2006，31，1： | 150 |
| 2 | 中间偃麦草的GISH分析显示文摘以染色体组为 Ee Ee 的二倍体长穗偃麦草 (Thinopyrum elongatum,2 n=2 x=1 4)、染色体组为 Eb Eb的二倍体比萨偃麦草 (Th.bessarabicum,2 n=2 x=1 4)、染色体组为 St St St St的四倍体拟鹅冠草 (Pseudoroegneiria strigosa,2 n=4x=2 8)的总基因组 DNA为探针 ,对中间偃麦草 (Th.intermedium)进行 GISH分析。结果表明 ,中间偃麦草是由 2个亲缘关系较近的染色体组、1个亲缘关系较远的染色体组构成 ;中间偃麦草所含的亲缘关系较近的染色体组分别与二倍体长穗偃麦草染色体组 Ee、比萨偃麦草染色体组 Eb、以及 1个亲缘关系较远的染色体组与拟鹅冠草染色体组 St 基本相似 ,但不完全一样。因而 ,中间偃麦草的染色体组用Eet Eet Ebt Ebt St | 吉万全 薛秀庄 王秋英 王长有 FEDAK George PATROSKI Rene 刘广田 | 2001 | 西北植物学报2001，21，3： | 29 |
| 3 | 回交高代选择导入系的纹枯病抗性与抗旱性的遗传重叠研究显示文摘利用来自抗旱性较好的供体亲本(BG300和BG304)、具有两种遗传背景(IR64和特青)的水稻高代回交(BC2)抗旱选择导入系,通过人工接种的方法鉴定纹枯病抗性,考察纹枯病抗性与抗旱性之间可能存在的遗传重叠。通过与受体亲本的纹枯病抗性表现比较发现,具有特青背景的抗旱选择导入系倾向于纹枯病抗性的降低,而IR64背景的抗旱选择导入系则倾向于纹枯病抗性的增强。基于基因型与表型的方差分析共鉴测到6个与纹枯病抗性相关的位点,其中QSbr6在不同供体和背景的两个群体中分别检测到,而QSbr10则在同一供体的两个遗传背景下均检测到;有3个位点(QSbr6、QSbr8和QSbr10)与同一群体中检测到的抗旱性位点位置相近,很可能是两种抗性重叠的遗传基础。尽管方差分析的方法在选择导入系的非选择目标性状相关位点的鉴定中存在相当程度的偏低估计,本研究所检测到的纹枯病抗性位点,特别是那些与抗旱性重叠位点的分子标记以及相关的抗性株系仍将为进一步的水稻纹枯病抗性和抗旱性的多抗性育种和深入的遗传重叠研究提供有用的信息和材料。 | 郑天清 徐建龙 傅彬英 高用明 Satish VERUKA Renee LAFITTE 翟虎渠 万建民 朱苓华 黎志康 | 2007 | 作物学报2007，33，8： | 25 |
| 4 | The Stripe Rust Resistance Gene Yr10 Encodes an Evolutionary-Conserved and Unique CC-NBS-LRR Sequence in Wheat显示文摘对用一条基于地图的克隆途径从摩洛人小麦(Triticum aestivum L.) 孤立的条纹锈的第一棵幼苗或所有阶段抵抗(R) R 基因作为 Yr10 被识别。这基因的克隆 4B 编码一高度,进化保存和唯一的 CCNBSLRR 定序。克隆 4E, Yr10 的一个相当或相同的事物,而是缺乏的抄写开始地点(TSS ) 和通常认为的 TATA 盒子和 CAAT 盒子,是可能的非表示的 pseudogene。克隆 4B 和 4E 是 84% 在 intron 和 LRR 领域相同、分叉。基因 silencing 和 transgenesis 与无毒害、剧毒的条纹锈尽力表明 Yr10 功能的差别与接种一起被使用。Yr10 CCNBSLRR 顺序在在小麦的已知的 CCNBSLRR R 基因之中是唯一的,但是高度保存相当或相同的事物(E = 0.0 ) 包括 Hordeum vulgare 和 Brachypodium distachyon 在 Aegilops tauschii 和另外的 monocots 被识别。相关序列也在玉米的 genomic 数据库被识别,米饭,并且在里面蜀黍。这是在有在它的本国的主人的有限相同,但是与在为条纹锈是主人或非主人的相关 monocots 的众多的相应 R 基因的植物的 CCNBSLRR 抵抗基因的第一份报告。这些结果越过种类代表基因进化和分散的一个唯一的例子。 | Wei Liu Michele Frick Rene Huel Cory L. Nykiforuk Xiaomin Wang Denis A. Gaudet Francois Eudes Robert L. Conner Alan Kuzyk Zhensheng Kang Andre Laroche | 2014 | Molecular Plant2014，7，12： | 21 |
| 5 | 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances显示文摘3D printing,an additive manufacturing based technology for precise 3D construction,is currently widely employed to enhance applicability and function of cell laden scaffolds.Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering.Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting.Other important factors include but are not limited to printing fidelity,stability,crosslinking time,biocompatibility,cell encapsulation and proliferation,shear-thinning properties,and mechanical properties such as mechanical strength and elasticity.In this review,we recite recent promising advances in bioink development as well as bioprinting methods.Also,an effort has been made to include studies with diverse types of crosslinking methods such as photo,chemical and ultraviolet(UV).We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks. | Soroosh Derakhshanfar Rene Mbeleck Kaige Xu Xingying Zhang Wen Zhong Malcolm Xing | 2018 | Bioactive Materials2018，3，2： | 21 |
| 6 | Spatial patterns of plant diversity and communities in Alpine ecosystems of the Hengduan Mountains, northwest Yunnan, China显示文摘Aims Conduct a quantitative,but rapid,regional-level assessment of the alpine flora across northwest Yunnan(NWY)to provide a broadbased understanding of local and regional patterns of the composition,diversity and health of alpine ecosystems across NWY.Methods A stratified random sampling design was employed to select sites across the different mountain ranges of NWY.Vegetation was sampled by stratifying each site by the three major alpine vegetation community types:meadow,dwarf shrub and scree.Two 50-m transects were randomly located within each community type at each sampling site with 101-m^(2) subplots systematically placed along each transect.Environmental variables were recorded at each transect.Multivariate analyses were used to classify the major plant community assemblages and link community patterns to environmental and habitat variables.Important Findings Forb species richness varied from 19 to 105 species per site(21 sites total)with an average of 59 species per site(60 m^(2) sampled per site).Most species were patchily distributed with narrow distributions and/or small population sizes;over half the species occurred at only one or two sites.Distinct species assemblages were identified in the meadow vegetation that was strongly aggregated by geographic location suggesting the presence of distinct phytogeographic zones of the meadow alpine flora.Elevation and geographic location were the dominant environmental gradients underlying the variations in species composition.Jaccard’s coefficient of similarity averaged only 10%among sites indicating there was little similarity in the alpine flora across the region.The alpine vegetation is highly heterogeneous across the complex landscape of the Hengduan Mountains of NWY.Conservation strategies need to take into account the large geographic differences in the flora to maximize protection of biodiversity. | Ruth Sherman Renee Mullen Li Haomin Fang Zhendong Wang Yi | 2008 | Journal of Plant Ecology2008，1，2： | 20 |
| 7 | 遗传搭车与方差分析在水稻定向选择群体的抗旱性位点分析中的初步应用显示文摘水稻抗旱性属于复杂性状,近年的遗传研究日益关注胁迫下的产量相关位点。选用来自同一抗旱性较好的供体亲本(BG300),具有两种遗传背景(IR64和特青)和两种选择条件(低地和旱地)的4个水稻高代回交(BC2)抗旱性定向选择导入系群体。通过SSR分子标记,检测群体中供体等位基因的导入频率,分析了选择条件和遗传背景对供体等位基因导入频率的影响。在此基础上,利用基于遗传搭车原理的卡方检验对等位基因导入频率的偏离进行检测,同时结合表型-基因型方差分析(ANOVA)的方法,对上述群体进行了和抗旱性相关位点的QTL分析。共检测到显著位点24个,其中卡方检验发现20个,方差分析检测到8个。有4个被这两种方法都检测到,很可能是与胁迫下的产量直接相关的位点。同时也对非胁迫下的产量位点进行了检测,发现上述抗旱性位点与非胁迫下产量的关系不大。还就选择条件和遗传背景的效应等对目标性状QTL定位的影响进行了讨论。研究结果将为进一步的水稻抗旱性分子育种研究提供有用的信息和材料。 | 郑天清 徐建龙 傅彬英 高用明 Satish VERUKA Renee LAFITTE 翟虎渠 万建民 朱苓华 黎志康 | 2007 | 作物学报2007，33，5： | 19 |
| 8 | Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage显示文摘Spontaneous intracerebral hemorrhage is a type of stroke associated with poor outcomes. Mortality is elevated, especially in the acute phase. From a pathophysiological point of view the bleeding must traverse different stages dominated by the possibility of re-bleeding, edema, intracranial hypertension, inflammation and neurotoxicity due to blood degradation products, mainly hemoglobin and thrombin. Neurological deterioration and death are common in early hours, so it is a true neurologicalneurosurgical emergency. Time is brain so that action should be taken fast and accurately. The most significant prognostic factors are level of consciousness, location, volume and ventricular extension of the bleeding. Nihilism and early withdrawal of active therapy undoubtedly influence the final result. Although there are no proven therapeutic measures, treatment should be individualized and guided preferably by pathophysiology. The multidisciplinary teamwork is essential. Results of recently completed studies have birth to promising new strategies. For correct management it's important to establish an orderly and systematic strategy based on clinical stabilization, evaluation and establishment of prognosis, avoiding secondary insults and adoption of specific individualized therapies, including hemostatic therapy and intensive control of elevated blood pressure. Uncertainty continues regarding the role of surgery. | Daniel Agustin Godoy Gustavo Rene Pi?ero Patricia Koller Luca Masotti Mario Di Napoli | 2015 | World Journal of Critical Care Medicine2015，4，3： | 14 |
| 9 | Disruptions in AUXl-Dependent Auxin Influx Alter Hypocotyl Phototropism in Arabidopsis显示文摘 | Bethany B. Stonea Emily L. Stowe-Evans Reneé M. Harper R. Brandon Celaya Karin Ljung Goran Sandbergc Emmanuel Liscum | 2008 | Molecular Plant2008，1，1： | 13 |
| 10 | 东方遇见西方:增龄性骨骼肌肉疾病的临床实践和策略显示文摘健康老龄化是指人在维持良好身体功能、保证生活质量前提下的衰老过程。这个过程能否实现取决于机体固有能力,一方面包括心理、生理能力,另一方面包括机体所处环境以及二者的相互作用。在老龄化进程中,骨骼肌肉健康是维持老年人身体功能的重要条件。全球肌少症、骨质疏松症和骨关节炎等老龄化相关的骨骼肌肉疾病及机体失能所致的负担正在增加,因此随着人口老龄化的加剧,防治这类疾病也尤为重要。以此为契机,中华医学会、中华医学会骨质疏松和骨矿盐疾病分会、欧洲骨质疏松和骨关节炎临床经济学会联合开设论坛,共同探讨增龄性肌肉骨骼疾病的现行临床诊治策略。本次会议邀请了中国和欧洲的专家到场,分享这3种疾病的临床诊治经验;双方通过经验交流、讨论异同以取长补短,从而实现对疾病的更佳防治,维持老年人的自身能力、延缓老龄化带来的身体功能退化。展望未来,希望双方经验及最佳临床实践的交流能推进全球战略,以减轻肌肉骨骼疾病的负担,促进符合个体化需求的健康老龄进程。 | 夏维波 Cyrus Cooper 李梅 徐苓 Rene Rizzoli 朱梅 林华 John Beard 丁悦 余卫 Etienne Cavalier 章振林 John A.Kanis 程群 王秋梅 Jean-Yves Reginster 冯亦鸣(翻译) | 2019 | 中华骨质疏松和骨矿盐疾病杂志2019，12，5： | 13 |
| 11 | Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner显示文摘AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain reaction.OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines.OPN expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture.Huh-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth.Expression of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and immunohistochemistry.RESULTS:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B and-C.OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue.Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium.Transfer of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner.Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect.OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative effect.CONCLUSION:This study demonstrates that OPN plays a significant role in the proliferation of HCC through interaction with the cell surface receptor CD44.Modulation of this interaction could represent a novel strategy for the control of HCC. | Renee J Phillips Karla J Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard | 2012 | World Journal of Gastroenterology2012，18，26： | 12 |
| 12 | 新技术应用——直接固体进样石墨炉分析显示文摘A new method, direct solid sampling graphite furnace AAS analysis, is introduced into real sample analysis. The determination of P in impregnated cotton and yarn (90 % cotton 10 % polyester) has been investigated as an example with the instrument of AAS vario 6, Analytik Jena AG. The RSD for 5 duplicates was between 2.3%~7.4%, comparable with liquid sampling graphite furnace AAS analysis. Direct solid sampling analysis can save a lot of work for sample processing, has benefits to avoid dilution and external contamination. | 赵泰 Rene Nowka | 2003 | 岩矿测试2003，22，1： | 11 |
| 13 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 14 | The role of the androgen receptor in prostate development and benign prostatic hyperplasia:A review显示文摘Benign prostatic hyperplasia(BPH)is a benign enlargement of the prostate in which incidence increases linearly with age,beginning at about 50 years old.BPH is a significant source of morbidity in aging men by causing lower urinary tract symptoms and acute urinary retention.Unfortunately,the etiology of BPH incidence and progression is not clear.This review highlights the role of the androgen receptor(AR)in prostate development and the evidence for its involvement in BPH.The AR is essential for normal prostate development,and individuals with defective AR signaling,such as after castration,do not experience prostate enlargement with age.Furthermore,decreasing dihydrotestosterone availability through therapeutic targeting with 5a-reductase inhibitors diminishes AR activity and results in reduced prostate size and symptoms in some BPH patients.While there is some evidence that AR expression is elevated in certain cellular compartments,how exactly AR is involved in BPH progression has yet to be elucidated.It is possible that AR signaling within stromal cells alters intercellular signaling and a“reawakening”of the embryonic mesenchyme,loss of epithelial AR leads to changes in paracrine signaling interactions,and/or chronic inflammation aids in stromal or epithelial proliferation evident in BPH.Unfortunately,a subset of patients fails to respond to current medical approaches,forcing surgical treatment even though age or associated co-morbidities make surgery less attractive.Fundamentally,new therapeutic approaches to treat BPH are not currently forthcoming,so a more complete molecular understanding of BPH etiology is necessary to identify new treatment options. | Renee E.Vickman Omar E.Franco Daniel C.Moline Donald J.Vander Griend Praveen Thumbikat Simon W.Hayward | 2020 | Asian Journal of Urology2020，7，3： | 11 |
| 15 | Magnetic resonance imaging in assessment of stress urinary incontinence in women: Parameters differentiating urethral hypermobility and intrinsic sphincter deficiency显示文摘AIM: To define the magnetic resonance imaging(MRI) parameters differentiating urethral hypermobility(UH) and intrinsic sphincter deficiency(ISD) in women with stress urinary incontinence(SUI).METHODS: The static and dynamic MR images of 21 patients with SUI were correlated to urodynamic(UD) findings and compared to those of 10 continent controls. For the assessment of the urethra and integrity of the urethral support structures, we applied the highresolution endocavitary MRI, such as intraurethral MRI, endovaginal or endorectal MRI. For the functional imaging of the urethral support, we performed dynamic MRI with the pelvic phased array coil. We assessed the following MRI parameters in both the patient and thevolunteer groups:(1) urethral angle;(2) bladder neck descent;(3) status of the periurethral ligaments,(4) vaginal shape;(5) urethral sphincter integrity, length and muscle thickness at mid urethra;(6) bladder neck funneling;(7) status of the puborectalis muscle;(8) pubo-vaginal distance. UDs parameters were assessed in the patient study group as follows:(1) urethral mobility angle on Q-tip test;(2) Valsalva leak point pressure(VLPP) measured at 250 cc bladder volume; and(3) maximum urethral closure pressure(MUCP). The UH type of SUI was defined with the Q-tip test angle over 30 degrees, and VLPP pressure over 60 cm H2 O. The ISD incontinence was defined with MUCP pressure below 20 cm H2 O, and VLPP pressure less or equal to 60 cm H2 O. We considered the associations between the MRI and clinical data and UDs using a variety of statistical tools to include linear regression, multivariate logistic regression and receiver operating characteristic(ROC) analysis. All statistical analyses were performed using STATA version 9.0(Stata Corp LP, College Station, TX).RESULTS: In the incontinent group, 52% have history of vaginal delivery trauma as compared to none in control group(P < 0.001). There was no difference between the continent volunteers and incontinent patients in body habitus as assessed by the body mass index. Pubovaginal distance and periurethral ligament disruption are significantly associated with incontinence; periurethral ligament symmetricity reduces the odds of incontinence by 87%. Bladder neck funneling and length of the suprapubic urethral sphincter are significantly associated with the type of incontinence on UDs; funneling reduced the odds of pure UH by almost 95%; increasing suprapubic urethral sphincter length at rest is highly associated with UH. Both MRI variables result in a predictive model for UDs diagnosis(area under the ROC = 0.944). CONCLUSION: MRI may play an important role in assessing the contribution of hypermobility and sphincteric dysfunction to the SUI in women when considering treatment options. | Katarzyna Jadwiga Macura Richard Eugene Thompson David Alan Bluemke Rene Genadry | 2015 | World Journal of Radiology2015，7，11： | 10 |
| 16 | Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism显示文摘We report an unusual case of spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma in an adult,non-pregnant woman.Her condition was triggered by unrecognized primary hypothyroidism,which regressed after thyroid hormone replacement therapy.This case highlights the need for clinicians and radiologists to familiarize themselves with the clinical and imaging features detected in case of these complications of primary hypothyroidism,which are not well known in the medical and radiological profession.Such improved knowledge will help avoid delays in diagnosis,progression to lifethreatening complications,and unnecessary surgery. | Rene Epunza Kanza Sylvain Gagnon Helene Villeneuve David Laverdiere Isabelle Rousseau Edith Bordeleau Michel Berube | 2013 | World Journal of Radiology2013，5，1： | 8 |
| 17 | 对转基因食品在日本消费者中认知程度和偏好的分析显示文摘对日本消费者关于转基因食品的态度进行实证研究。通过抽样调查,结果显示,由于出于不同考虑日本消费者对转基因食品表现出了不同程度的认可与兴趣。超过30%的调查对象既不愿意为转基因食品支付额外费用,也不愿意以折扣价格购买,这说明日本的消费者还没有确立转基因食品在他们消费意识中的位置。然而,结果也显示,如果转基因食品能够满足消费者特殊消费效用,并使消费者得到其相关的信息,那么,第二代转基因食品在日本是有潜力的。其中具有医学效用的转基因食品、转基因水果和蔬菜是最受日本消费者欢迎的转基因食品类型。 | Renee Kim 张峭 潘月红 | 2006 | 农业展望2006，2，11： | 8 |
| 18 | Trithorax Group Proteins Act Together with a Polycomb Group Protein to Maintain Chromatin Integrity for Epigenetic Silencing during Seed Germination in Arabidopsis显示文摘Polycomb 组(PcG ) 和蛋白质被给看了反对地行动 epigenetically 在优核质调整基因表示的 trithorax 组(trxG ) 。trxG 蛋白质在另外的发展过程在 Arabidopsis,而是他们的角色抵抗调停 PcG 的花的压抑糟糕被理解。我们调查了在 trxG 之间的相互作用基因, TRITHORAX1 (ATX1 ) 的 ARABIDOPSIS 相当或相同的事物和 ULTRAPETALA1 (ULT1 ) ,和 PcG 基因胚胎的花 1 (EMF1 ) 在早开发期间。出人意料地,我们发现在 trxG 基因的变化没能救 emf1 异种的早花的显型。相反, emf1 atx1 ult1 幼苗显示出新奇的肿的根显型和基因表示的巨大的解除管制。在 emf1 atx1 ult1 的规章的基因比在 emf1 单身者异种增加两倍的种子主人的更大的宫外的表示一起显示那 PcG 和 trxG 因素镇压在萌芽以后的种子基因表示。而且,我们发现普遍基因 derepression 与 H3K27me3 的减少的层次被联系, epigenetic 基因表示的压抑的标记,并且与全球性改变的染色质组织。EMF1, ATX1,和 ULT1 能绑种子基因的染色质, ULT1 能身体上与 ATX1 和 EMF1 交往,建议 trxG 和 EMF1 蛋白质直接在为调停 EMF1 的基因 silencing 的目标基因 loci 联系。因此,当 ATX1, ULT1,和 EMF1 反对地交往调整 flowering 时,他们一起工作维持染色质完整并且在萌芽以后阻止早熟的种子基因表示。 | Fan Xu Tony Kuo Yenny Rosli Mao-Sen Liu Limin Wu Long-Fang Oliver Chen Jennifer C. Fletcher Zinmay Renee Sung Li Pu | 2018 | Molecular Plant2018，11，5： | 8 |
| 19 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 20 | Modeling sarcomagenesis using multipotent mesenchymal stem cells显示文摘因为他们的唯一的性质,间充质的干细胞(MSC ) 代表最有希望的成年干细胞之一在临床的应用的一个宽数组全球正在被使用的 multipotent。总的来说,引人注目的证据支持前 vivo 的长期的安全扩展了人的 MSC,它不似乎自发地转变。然而,试验性的数据表明在 MSC 和癌症之间的一个连接,和 MSC 被报导了禁止或支持肿瘤生长取决于还未定义的条件。有趣地,稳固的证据为某些肉瘤基于转基因的老鼠和 MSC 的基因干预把这些房间放作为起源的最可能的房间。这个研究区域逐渐地正在被探索开发 sarcomagenesis 的精确基于 MSC 的模型,它将在关于间充质的癌症的病原学和致病提供更好的理解无疑是珍贵的,最后导致更特定的治疗的发展对开始肉瘤的房间指导了。不幸地,仍然,很少对位于 MSC 转变下面的机制被知道,进一步的研究被要求基于人的 MSC 开发真正的肉瘤模型。这里,我们包括地考察存在肉瘤的基于 MSC 的模型并且讨论导致 MSC 和 sarcomagenesis 的 tumoral 转变的最普通的机制。 | Rene Rodriguez Ruth Rubio Pablo Menendez | 2012 | Cell Research2012，22，1： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员