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| 1 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 2 | Carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference显示文摘 | Wang SC Liu H Ren LF | 2008 | Neoplasia2008，10，4： | 1 |
| 3 | Effect of cisaprlde on intestinal bacterial and endotoxin translocation in cirrhosis显示文摘 | ZHANG SC WANG W REN WY | | 0，，03： | 1 |
| 4 | The prevention of endermic enffusion after cranioplasty 显示文摘 | Zhang J Huang SC Ren LZ | 2001 | Anthlo Med2001，5，4： | 1 |
| 5 | Inhibiting Colorectal Carcinoma Growth and Metastasis By Blocking the Expression of VEGF Using RNA Interference 显示文摘 | Wang SC Liu H Ren LF | 2008 | Neoplasia2008，10，4： | 1 |
| 6 | The prevention of endermic effusion after cranioplasty显示文摘 | Zhang J Huang SC Ren LZ | | 0，，04： | 1 |
| 7 | Thulium laser resection via a flexible cystoscope for recurrent non-muscle-invasive bladder cancer:initial clinical experience显示文摘 | Gao X Ren SC Xu CL | 2008 | BJM Int2008，102，9： | 1 |
| 8 | Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians显示文摘 | Chu W Ren Q | 2002 | Clin Endocrinol Metab2002，87，： | 1 |
| 9 | RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex显示文摘 | Tang H Park S Sun SC Trumbly R Ren G Tsung E | 2010 | FEBS Lett2010，584，4： | 1 |
| 10 | Role of calpain 10 in genevariation in familial type 2 diabetes in Caucasians 显示文摘 | Elbein SC Chu W Ren Q | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 11 | Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference 显示文摘 | WANG SC LIU H REN LF | 2008 | Neoplasia2008，10，4： | 1 |
| 12 | Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians显示文摘 | Elbein SC Chu W Ren Q | 2002 | J Clin Endocrinol Metab2002，87，2： | 1 |
| 13 | Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians显示文摘 | Elbein SC Chu W Ren Q | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 14 | Hyperactive phosphoinositide signaling pathway in platelets of depressed patients:effect of desipramine treatment显示文摘 | Pandey GN Ren X Pandey SC | 2001 | Psychiatry Research2001，105，12： | 1 |
| 15 | Progressive alterations of hipp- ocampal CA3-CA1 synapses in an animal model of depressian显示文摘 | Qiao H An SC Ren W | 2014 | Behav Brain Res2014，275，： | 1 |
| 16 | Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish显示文摘 | Ren C Xin SC Li S | 2011 | PLoS One2011，6，20： | 1 |
| 17 | Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference显示文摘 | Wang SC Liu H Ren LF | | 0，，04： | 1 |
| 18 | Inhibito-ry effects of30kinds of Chinese herbal medicine on bacteria in food显示文摘 | REN SC FAN YC LI CC | 2010 | Medici-nal Plant2010，1，5： | 1 |
| 19 | Vasovagal syncope显示文摘 | Fenton AM Hammill SC Ren RF | 2000 | Ann Intern Med2000，133，9： | 1 |
| 20 | Schiff base of aminohydroxy guanidine as inhibitors of growth/replication & QSAR analysis 显示文摘 | Ren Shijun Tokes Zoltan A | 2002 | Med Chem Resear2002，11，3： | 1 |
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