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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Adolescents with major depression demonstrate increased amygdala aetivation显示文摘 | Yang TT Simmons AN Matthews SC | 2010 | J Am Aead Child Adolesc Psychiatry2010，49，： | 1 |
| 3 | Long survival of patients with small cell lung Cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Cahnette-Gu rin 显示文摘 | Grant SC Kris MG Houghton AN | 1999 | Clin Cancer Res1999，5，6： | 1 |
| 4 | Safety and side effects of the insulin analogues显示文摘 | Kamal AD Dixon AN Bain SC | 2006 | Expert Opin Drug Saf2006，5，1： | 1 |
| 5 | Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Gu6rin显示文摘 | Grant SC Kris MG Houghton AN | 1999 | Clin Cancer Res1999，5，6： | 1 |
| 6 | Association of major depressive disorder with altered functional brain re- sponse during anticipation and processing of heat pain显示文摘 | Strigo A Simmons AN Matthews SC | 2008 | Arch Gen Psychiatry2008，65，11： | 1 |
| 7 | In vitro mechanism of inhibition of bacterial growth by allium显示文摘 | Feidberg GS Chang SC Kotik AN | 1988 | Agents Chemother1988，32，12： | 1 |
| 8 | Safety and effects of the insulin analogues显示文摘 | Kamal AD Dixon AN Bain SC | 2006 | Expert Opin Drug Saf2006，5，： | 1 |
| 9 | All wrapped up and nowhereto flow显示文摘 | Amir AN Brian AH John SC | 2012 | Am J Med2012，125，9： | 1 |
| 10 | Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder显示文摘 | Strigo lA Matthews SC Simmons AN | 2013 | Transl Psychiatry2013，3，： | 1 |
| 11 | Self -citation:com parisonetween Radiology, European Radiology and adiology for 1997-1998显示文摘 | Larcombe AN Voss SC | 2011 | Scientometrics2011，87，： | 1 |
| 12 | Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers显示文摘 | Matthews SC Simmons AN Strigo IA | | 0，，： | 1 |
| 13 | Triple combinations of neuraminidase inhibitors,statins and fibrates benefit the survival of patients with lethal avian influenza pandemic显示文摘 | An SC Xu LL Li FD | 2011 | Med Hypotheses2011，77，6： | 1 |
| 14 | Twenty years' ex- perience of steroids in infantile hemangioma -- a developing country's perspective显示文摘 | Pandey A Gangopadhyay AN Gopal SC | 2009 | J Pediatr Surg2009，44，4： | 1 |
| 15 | Effects of stir- ring and fluid perfusion on the in vitro degradation of Calci- um phosphate eement/PLGA composites 显示文摘 | An J Leeuwenburgh SC Wolke JG | 2015 | Tissue Eng Part C Methods2015，21，11： | 1 |
| 16 | Role of fibrin glue as a sealant to esophageal anastomosis in cases of congenital esophageal atresia with racheoesophageal fistula显示文摘 | Upadhyaya VD Gopal SC Gangopadhyaya AN | 2007 | World J Surg2007，31，： | 1 |
| 17 | Pigment epithelial-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells 显示文摘 | Cheung LW Au SC Cheung AN | 2006 | Endocrinology2006，147，： | 1 |
| 18 | Twenty years'experience of steroids in infantile hemangioma-A developing country perspective 显示文摘 | Pandey A Gangopadhuay AN Gopal SC | 2009 | Ped Surg2009，44，4： | 1 |
| 19 | Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress显示文摘 | Luo DD An SC Zhang X | | 0，，01： | 1 |
| 20 | Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells显示文摘 | Cheung LW Au SC Cheung AN | | 0，，： | 1 |
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