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| 1 | Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53- dependent regulation of migrating cardiac neural crest 显示文摘 | Morgan SC Lee HY Relaix F | 2008 | Mech Dev2008，125，910： | 1 |
| 2 | Pw1/Peg3 is a potential cell death mediator and cooperates with Siam a in p53-mediated apoptosis 显示文摘 | Relaix F Wei X Li W | 2000 | Proc Natl Acad Sci U S A2000，97，： | 1 |
| 3 | Master regulators of skeletal muscle lineage development and pluripotent stem cells differentiation显示文摘In vertebrates, the skeletal muscles of the body and their associated stem cells originate from muscle progenitor cells,during development. The specification of the muscles of the trunk, head and limbs, relies on the activity of distinctgenetic hierarchies. The major regulators of trunk and limb muscle specification are the paired-homeobox transcriptionfactors PAX3 and PAX7. Distinct gene regulatory networks drive the formation of the different muscles of thehead. Despite the redeployment of diverse upstream regulators of muscle progenitor differentiation, the commitmenttowards the myogenic fate requires the expression of the early myogenic regulatory factors MYF5, MRF4, MYOD andthe late differentiation marker MYOG. The expression of these genes is activated by muscle progenitors throughoutdevelopment, in several waves of myogenic differentiation, constituting the embryonic, fetal and postnatal phases ofmuscle growth. In order to achieve myogenic cell commitment while maintaining an undifferentiated pool of muscleprogenitors, several signaling pathways regulate the switch between proliferation and differentiation of myoblasts.The identification of the gene regulatory networks operating during myogenesis is crucial for the development ofin vitro protocols to differentiate pluripotent stem cells into myoblasts required for regenerative medicine. | Joana Esteves de Lima Frederic Relaix | 2021 | Cell Regeneration2021，10，1： | 1 |
| 4 | Pax3 and pax7 have distinct and overlapping functions in adult muscle progenitor cells显示文摘 | Relaix F Montarras D Zaffran S | 2006 | J Cell Biol2006，172，1： | 1 |
| 5 | pax7 and myogenic progression in skeletal muscle satellite cells显示文摘 | Zammit PS Relaix F Nagata Y | 2006 | J Cell Sci2006，119，9： | 1 |
| 6 | Pax3 and Pax7 have distinct and overlapping function in adult muscle progenitor cells显示文摘 | RELAIX F MONTARRAS D ZAFFRAN S | | 0，，01： | 1 |
| 7 | Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage显示文摘 | Relaix F Zammit PS | 2012 | Development2012，139，16： | 1 |
| 8 | HACD1,a regulator of membrane composition and fluidity,promotes myoblast fusion and skeletal muscle growth显示文摘The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies,yet the underlying cellular and molecular mechanisms remain elusive.In this study,we investigate the role of HACD1/PTPLA,which is involved in the elongation of the very long chain fatty acids,in muscle fibre formation.In humans and dogs,HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscleweakness.Throughanalysis of HACD1-deficient Labradors,Hacd1-knockout mice,and Hacd1-deficient myoblasts,we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration.We further demonstrate that in normal differentiating myoblasts,expression of the catalytically active HACD1 isoform,which is encoded by a muscle-enriched splice variant,yields decreased lysophosphatidylcholine content,a potent inhibitor of myoblast fusion,and increased concentrations of≥C18 and monounsaturated fatty acids of phospholipids.These lipid modifications correlate with a reduction in plasma membrane rigidity.In conclusion,we propose that fusion impairment constitutes a novel,non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. | Jordan Blondelle Yusuke Ohno Vincent Gache Stephane Guyot Sebastien Storck Nicolas Blanchard-Gutton Ines Barthelemy Gemma Walmsley Anaelle Rahier Stephanie Gadin Marie Maurer Laurent Guillaud Alexandre Prola Arnaud Ferry Genevieve Aubin-Houzelstein Jean Demarquoy Frederic Relaix Richard JPiercy Stephane Blot Akio Kihara Laurent Tiret Fanny Pilot-Storck | 2015 | Journal of Molecular Cell Biology2015，7，5： | 1 |
| 9 | A Pax3/pax7-dependent population of skeletal muscle progenitor cells显示文摘 | Relaix F Rocancourt D Mansouri A | 2005 | Nature2005，435，7044： | 1 |
| 10 | The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions 显示文摘 | Buckingham M Relaix F | 2007 | Annu Rev Cell Dev Biol2007，23，1： | 1 |
| 11 | Pax7 and myogenic progression in skeletal muscle satellite cells 显示文摘 | Zammit PS Relaix F Nagata Y | 2006 | J Cell Science2006，119，9： | 1 |
| 12 | Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects显示文摘 | Morgan SC Relaix F Sandell LL | 2008 | Birth Defects Res A Clin Mol Teratol2008，82，6： | 1 |
| 13 | Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells显示文摘 | Relaix F Montarras D Zaffran S | 2008 | Journal of Cell Biology2008，172，1： | 1 |
| 14 | Divergent functions of murine Pax3 and Pax7 in limb muscle development显示文摘 | Relaix F Rocancourt D Mansouri A | 2004 | Genes Dev2004，18，9： | 1 |
| 15 | A Pax3/Pax7- dependent population of skeletal muscle progenitor cells显示文摘 | Relaix F Rocancourt D Buckingham M | 2005 | Nature2005，435，7044： | 1 |
| 16 | The role of Pax genes in the developmentof tissues and organs : Pax3 and Pax7 regulate muscle progenitor cell functions 显示文摘 | Buckingham M Relaix F | 2007 | Annu Rev Cell Dev Biol2007，23，： | 1 |
| 17 | Pax3 GFP , a new reporter for the melanocyte lineage, highlights novel aspects of PAX3 expression in the skin显示文摘 | Johanna Djian‐Zaouche Cécile Campagne Edouard Reyes‐Gomez Stéphanie Gadin‐Czerw Florence Bernex Anne Louise Frédéric Relaix Margaret Buckingham Jean‐Jacques Panthier Geneviève Aubin‐Houzelstein | 2012 | Pigment Cell & Melanoma Research2012，，5： | 1 |
| 18 | A Pax3/Pax7-dependent Population of Skeletal Muscle Progenitor Cells显示文摘 | RELAIX F ROCANCOURT D MANSOURI A | 2005 | Nature2005，435，7044： | 1 |
| 19 | Broadband reflective cholesteric liquid crystalline gels : Volume distri- bution of reflection properties and polymer network in rela- tion with the geometry of the cell photopolymerization 显示文摘 | RELAIX S BOURGERETrE C MITOV M | 2007 | Liquid Crystals2007，34，9： | 1 |
| 20 | Pax7 and myogenic progression in skeletal muscle satellite cells显示文摘 | Zammit PS Relaix F Nagata Y | 2006 | J Cell Sci2006，119，9： | 1 |
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