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| 1 | Interleukin-6: a villain in the drama of pancreatic cancer development and progression显示文摘BACKGROUND: Pancreatic ductal adenocarcinoma(PDAC)is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6(IL-6), which plays an important role in a wide range of biologic activities.DATA SOURCES: A systematic search of PubMed was performed to identify relevant studies using key words such as interleukin-6,inflammatory cytokines, inflammation and pancreatic cancer or PDAC. Articles related to IL-6 and pancreatic cancer were systematically reviewed.RESULTS: IL-6 is elevated in the serum of pancreatic cancer patients and correlates with cachexia, advanced tumor stage and poor survival. Its expression is enhanced by hypoxia and proteins involved in pancreatic cancer development like Kras,mesothelin or ZIP4. IL-6 in turn contributes to the generation of a pro-tumorigenic microenvironment and is probably involved in angiogenesis and metastasis. In experimental mouse models of PDAC, IL-6 was important for the development and progression of precursor lesions.CONCLUSION: IL-6 emerges as a key player in pancreatic cancer development and progression, and hence should be considered as a new therapeutic target. | Reinhild Holmer Freya A Goumas Georg H Waetzig Stefan Rose-John Holger Kalthoff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 16 |
| 2 | Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis显示文摘AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as controls.RESULTS:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC. | Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein | 2010 | World Journal of Gastroenterology2010，16，8： | 13 |
| 3 | Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities显示文摘Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma(PRP) therapy is a promising treatment for musculoskeletal injuries.Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field.Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms.This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and(pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed. | Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs | 2017 | International Journal of Oral Science2017，9，1： | 10 |
| 4 | Sensory innervation around immediately vs. delayed loaded implants: a pilot study显示文摘Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks(third maxillary incisor, third and fourth mandibular premolar): immediate implant placement and immediate loading(IIP1IL);delayed implant placement and delayed loading(DIP1DL); delayed implant placement and immediate loading(DIP1IL); and natural extraction socket healing(control). Histomorphometry was performed in the peri-implant bone and soft tissues within 300 mm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP1 IL showed a higher innervation(in Nmm22, 5.9461.12 vs. 3.1560.63,P,0.001) and smaller fibre diameter(in mm, 1.3760.05 vs. 1.6460.13, P50.016), smaller axon diameter(in mm, 0.8960.05 vs.1.2460.10, P50.009) and g-ratio(0.6460.04 vs. 0.7660.05, P,0.001) in the middle region around the implants. Compared with DIP1 IL in the mandible, IIP1 IL had a higher nerve density(in Nmm22, 13.2362.54 vs. 9.6461.86, P50.027), greater fibre diameter(in mm, 1.3260.02 vs. 1.2060.04, P50.021), greater axon diameter(in mm, 0.9260.01 vs. 0.8960.03, P50.035) and lower g-ratio(0.6960.01 vs. 0.7460.01, P50.033) in the apical region around the implants. It may be assumed that the treatment protocol with IIP1 IL is the preferred method to allow optimized peri-implant re-innervation, but further functional measurements are still required. | Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs | 2015 | International Journal of Oral Science2015，7，1： | 7 |
| 5 | Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery显示文摘The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography(MSCT) and postoperative cone-beam computed tomography(CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients(11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure.A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter-and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant(P<0.05) mean bone volume decrease of 26.4% ± 11.4%(502.9 mm^3± 268.1 mm^3). No significant effects of side, sex or age were found. Good to excellent(ICC>0.6) intra-and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel(0.4 mm) for MSCT(0.3 mm ± 0.2 mm) and CBCT(0.4 mm ± 0.3 mm), thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption. | laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs | 2017 | International Journal of Oral Science2017，9，3： | 7 |
| 6 | Validating cone-beam computed tomography for peri-implant bone morphometric analysis显示文摘Cone-beam computed tomography(CBCT) has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional(3D) peri-implant trabecular bone morphometry by comparing it to two-dimensional(2D) histology, 36 alveolar bone samples(with implants n527 vs. without implants n59) from six mongrel dogs, were scanned ex vivo using a high-resolution(80 mm)CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections(,6 mm)to obtain high contrast 2D images. By using CTAn imaging software, bone morphometric parameters including trabecular number(Tb.N), thickness(Tb.Th), separation(Tb.Sp) and bone volume fraction(BV/TV) were examined on both CBCT and corresponding histological images. Higher Tb.Th and Tb.Sp, lower BV/TV and Tb.N were found on CBCT images(P,0.001). Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation(r50.65–0.85). The Bland–Altman plots showed strongest agreement for Tb.Th followed by Tb.Sp, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation. | Yan Huang Jeroen Van Dessel Maarten Depypere Mostafa EzEldeen Alexandru Andrei Iliescu Emanuela Dos Santos Ivo Lambrichts Xin Liang Reinhilde Jacobs | 2014 | Bone Research2014，2，2： | 3 |
| 7 | Make and buy in innovation strategies: evidence from Belgian manufacturing firms显示文摘 | Reinhilde Veugelers Bruno Cassiman | 1999 | Research Policy1999，，1： | 2 |
| 8 | In-vitro comparison of 2 cone-beam computed tomography systems and panoramic imaging for detecting simulated canine impaction-induced external root resorption in maxillary lateral incisors显示文摘 | Ali Alqerban Reinhilde Jacobs Paulo Couto Souza Guy Willems | 2009 | American Journal of Orthodontics & Dentofacial Orthopedics2009，，6： | 1 |
| 9 | Reputation as Mechanism Alleviating Opportunistic Host Government Behavior Against MNEs 显示文摘 | Veugelers Reinhilde | 1993 | The Journal Industrial Economics1993，41，1： | 1 |
| 10 | R&D cooperation between firms and universities:Some empirical evidence from Belgian manufacturing显示文摘 | Reinhilde Veugelers Bruno Cassiman | 2005 | International Journal of Industrial Organization2005，，23： | 1 |
| 11 | Make and buy in innovation strategies:evidence from Belgian manufacturing finns显示文摘 | Veugelers Reinhilde Cassiman Bruno | 1999 | Research Policy1999，28，1： | 1 |
| 12 | European anti - dumping policy and the profitability of national and international collousion 显示文摘 | REINHILDE V HYLKE V | 1999 | European Economic Review1999，43，1： | 1 |
| 13 | Internal R & D expenditures and external technology sourcing显示文摘 | Reinhilde Veugelers | 1997 | Research Policy1997，，3： | 1 |
| 14 | Bargained shares in joint ventures among asymmetric partners: Is the matthew effect catalyzing?显示文摘 | Reinhilde Veugelers Katrien Kesteloot | 1996 | Journal of Economics Zeitschrift für National?konomie1996，，1： | 1 |
| 15 | Biomechanics and Biocompatibility of Woven Spider Silk Meshes During Remodeling in a Rodent Fascia Replacement Model显示文摘 | Franziska Sch?fer-Nolte Kathleen Hennecke Kerstin Reimers Reinhild Schnabel Christina Allmeling Peter M. Vogt Joern W. Kuhbier Ursula Mirastschijski | 2014 | Annals of Surgery2014，，4： | 1 |
| 16 | R&D Cooperation and Spillovers: Some Empirical Evidence 显示文摘 | Cassiman Bruno Reinhilde Veugelers | 2002 | American Economic Review2002，，92： | 1 |
| 17 | A comparison of jaw dimensional and quality assessments of bone characteristics with cone-beam CT, spiral tomography,and multi-slice spiral CT显示文摘 | Miel L Maria EG Reinhilde J | 2007 | Int J Oral Maxillofac Implants2007，22，3： | 1 |
| 18 | Reputation As A Mechanism Alleviating Opportunistic Host Government Behavior Against MNEs显示文摘 | Reinhilde Veugelers | 1993 | The Journal of Industrial Economics1993，，3： | 1 |
| 19 | For- eign subsidiaries as a channel of international technology diffusion: some direct firm level evidence from Belgium 显示文摘 | REINHILDE VEUGELERS BRUNO CASSIMAN | 2004 | European Economic Review2004，48，2： | 1 |
| 20 | R&Dcooperation between firms and universities: some empirical evi-dence from Belgian manufacturing 显示文摘 | REINHILDE VEUGELERS BRUNO CASSIMANA | 2005 | International Journal ofIndustrial Organization2005，，23： | 1 |
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