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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 3 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 4 | Why we milk sows显示文摘 | G REINER ETAL | 1995 | Pig International1995，，： | 1 |
| 5 | ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the man- agement of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)显示文摘 | Reiner Catapano AL De Backer G | 2011 | Eu- ropean heart journal2011，32，14： | 1 |
| 6 | Emerging roles of caspase-3 in apoptosis显示文摘 | Alan G Porter Reiner U | 2006 | Cell Death Different2006，6，2： | 1 |
| 7 | Biota and the world carbon budget 显示文摘 | Woodwell G M Whitaker R H Reiners W A | 1978 | Science1978，199，4325： | 1 |
| 8 | Encephalo-myelo-radiculo- ganglionitis presenting as pandysautonomia 显示文摘 | Stoll G Thomas C Reiners K et ol | 1991 | Neurology1991，41，5： | 1 |
| 9 | SC/EAS Guidelines for the management of dyslipidaemias显示文摘 | Reiner Z Catapano AL De Backer G | 2011 | Eur Heart J2011，32，： | 1 |
| 10 | Decorative optical coatings 显示文摘 | Reiners G Beck U Jehn H A | 1994 | Thin Solid Films1994，253，： | 1 |
| 11 | The biota and the world carbon budget 显示文摘 | Woodwell G M Whittaker R H Reiners W A | 1978 | Science1978，199，： | 1 |
| 12 | The biota and the world carbon budget显示文摘 | Woodwel G M Whittacker R H Reiners W A etal | 1978 | Science1978，199，： | 1 |
| 13 | Mechanical properties of SiO2 and Si3N4 coatings: a BAM/ NIST co-operative project 显示文摘 | BECK U SMITH D T REINERS G | 1998 | Thin Solid Films1998，332，12： | 1 |
| 14 | Distribution of of porcine circovi- boars and domestic pigs in Germany显示文摘 | Reiner G Bronnert B et ORF2 and ORF3 genotypes rus type2(PCV2) in wild al | 2011 | Vet Microbiol2011，148，37： | 1 |
| 15 | Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression显示文摘 | MARTINS G A HUTCHINS A S REINER S L | 2005 | J Immunol2005，175，9： | 1 |
| 16 | ESC/EAS guidelines for the management of dyslipidaemias: The task force for the management of dyslipidaemias of the European Society of Cardiology ( ESC ) and the European Atherosclerosis Society ( EAS ) 显示文摘 | Catapano A L Reiner Z De Backer G | 2011 | Atherosclerosis2011，217，1： | 1 |
| 17 | ESC/EAS Guidelines for the management of dyslipidaemias:the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)显示文摘 | Reiner Z Catapano AL De Backer G | | 0，，14： | 1 |
| 18 | Advanced modelling for CAD/CAM systems显示文摘 | Hans G rabowski Reiner Anderl Michael J Pratt | 1991 | Research Reports ESPRIT1991，7，1： | 1 |
| 19 | The biota and the world carbon budget显示文摘 | WOODWELL G M WHITAKER R H REINERS W A | 1978 | Science1978，199，： | 1 |
| 20 | Robust Dynamic Inversion for Control of Highly Maneuverable Aircraft显示文摘 | REINER J BALAS G J WILLIAM L G | 1995 | Journal of Guidance Control and Dynamics1995，18，1： | 1 |
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