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| 1 | Hepatocellular adenoma: An unsolved diagnostic enigma显示文摘Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization. | Matteo Renzulli Alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri | 2019 | World Journal of Gastroenterology2019，25，20： | 12 |
| 2 | Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?显示文摘AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging(7T-MRI)in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.GroupⅠ underwent inferior mesenteric artery(IMA)ligation followed by macroscopic observations and histological analysis.In groupⅡ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation;the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings. | Francesca Iacobellis Daniela Berritto Francesco Somma Carlo Cavaliere Marco Corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，13： | 7 |
| 3 | 神经内镜经鼻蝶入路鞍区及鞍旁区手术的进展显示文摘真正意义上的神经内镜经鼻蝶入路手术开始于20世纪90年代,并且伴随着医学设备、器械的进步,这种技术方式发展非常迅猛,正在受到越来越多的关注。和常规显微镜手术比较,神经内镜鞍区及鞍旁区手术有着较独特的优点,但是也存在相对的局限性,随着医生经验的积累和科技的进步,这种局限性正在缩小。该文就其历史发展现状和前景做一综述。 | 展如才 Cappabianca Paolo | 2011 | 中国内镜杂志2011，17，7： | 4 |
| 4 | Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting显示文摘Pediatric neuroblastomas(NBs)are heterogeneous,aggressive,therapy-resistant embryonal tumours that originate from cells of neural crest(NC)origin and in particular neuroblasts committed to the sympathoadrenal progenitor cell lineage.Therapeutic resistance,post-therapeutic relapse and subsequent metastatic NB progression are driven primarily by cancer stem cell(CSC)-like subpopulations,which through their self-renewing capacity,intermittent and slow cell cycles,drug-resistant and reversibly adaptive plastic phenotypes,represent the most important obstacle to improving therapeutic outcomes in unfavourable NBs.In this review,dedicated to NB CSCs and the prospects for their therapeutic eradication,we initiate with brief descriptions of the unique transient vertebrate embryonic NC structure and salient molecular protagonists involved NC induction,specification,epithelial to mesenchymal transition and migratory behaviour,in order to familiarise the reader with the embryonic cellular and molecular origins and background to NB.We follow this by introducing NB and the potential NC-derived stem/progenitor cell origins of NBs,before providing a comprehensive review of the salient molecules,signalling pathways,mechanisms,tumour microenvironmental and therapeutic conditions involved in promoting,selecting and maintaining NB CSC subpopulations,and that underpin their therapy-resistant,self-renewing metastatic behaviour.Finally,we review potential therapeutic strategies and future prospects for targeting and eradication of these bastions of NB therapeutic resistance,post-therapeutic relapse and metastatic progression. | Antonietta Rosella Farina Lucia Annamaria Cappabianca Veronica Zelli Michela Sebastiano Andrew Reay Mackay | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 5 | Simultaneous presentation of meningiomas with other intraeranial tumours显示文摘 | Maiuri F Cappabianca P Iaconetta G | 2005 | Br J Neurosurg2005，9，4： | 1 |
| 6 | Sellar repair in endoscopic endonasal transsphenoidal surgery: results of 170cases 显示文摘 | Cavallo LM Esposito F | 2002 | Neurosurgery2002，51，6： | 1 |
| 7 | Very delayed hy- ponatremia after surgery and radiotherapy for pituitary macroade- noma 显示文摘 | Fillipella M Cappabianca P Cavallo LM | 2002 | J Endocrinol Invest2002，25，2： | 1 |
| 8 | The medical treatment of Cushing's disease:effectiveness of chronic treat- ment with the dopamine agonist cabergoline in patients unsuc- cessfully treated by surgery显示文摘 | Pivonello R De Martino MC Cappabianca P | 2009 | J Clin Endocrinol Metab2009，94，1： | 1 |
| 9 | Endoscopic endonasal transsphenoidal surgery显示文摘 | de Divitiis E Cappabianca P | 2002 | Adv Tech Stand Neurosurg2002，27，： | 1 |
| 10 | Easy sellar reconstruction in endoscopic endonasal transsphenoidal surgery with polyester-silicone dural substitute and fibrin glue:technical note 显示文摘 | Cavallo LM Mariniello G | 2001 | Neurosurgery2001，49，2： | 1 |
| 11 | Very delayed hyponatremia after surgery and radiotherapy for a pituitary macroadenoma显示文摘 | Cappabianca P Cavallo LM | 2002 | J Endocrinol Invest2002，25，2： | 1 |
| 12 | Surgical com- plications associated with the endoscopic endonasal trans- sphenoidal approach for pituitary adenomas 显示文摘 | Cappabianca P Cavallo LM Colao A | 2002 | Neuro- surg2002，97，2： | 1 |
| 13 | Extendedendoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors:part 2显示文摘 | de Divitiis E Cavallo LM Cappabianca P | 2007 | Neurosurgery2007，60，1： | 1 |
| 14 | Extended endoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors:part 2显示文摘 | De Divitiis E Cavallo LM Cappabianca P | | 0，，01： | 1 |
| 15 | Cranio- pharyngiomas显示文摘 | CAPPABIANCA P CAVALLO L M ESPOSITO F | 2008 | J Neurosurg2008，109，1： | 1 |
| 16 | Ogilvie's syndrome (acute colonic pseudo-obstruction):review of the literature and report of 6additional cases显示文摘 | Grassi R Cappabianca S Porto A | 2005 | Radiol Med2005，109，4： | 1 |
| 17 | Role of multidetector row computed tomography in the management of mandible traumatic lesions显示文摘 | Remeo A Pinto A Cappabianca $ | 2009 | Semin Ultrasound CT MR2009，30，17： | 1 |
| 18 | Endoscopic pitu-itary surgery 显示文摘 | Cappabianca P Cavallo LM de Divitiis O | 2008 | Pituitary2008，11，4： | 1 |
| 19 | Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas显示文摘 | Cappabianca P Cavallo LM Colao A | 2002 | J Neurosurg2002，97，2： | 1 |
| 20 | Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions 显示文摘 | Cappabianca P Cavallo LM | 2002 | Neurosurgery2002，51，3： | 1 |
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