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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Racial identity, African self- conscious- hess, and career decision making in African American college women显示文摘 | Carla J Reginald J | 1998 | Journal of M- ulticuhural Counseling and Devel- opment1998，，1： | 1 |
| 3 | Anatomy of the calcaneus显示文摘 | Reginald L Hall MD Michael J | 1993 | Clin Othop1993，293，： | 1 |
| 4 | Racial identity,African self- consciousness, and career decision making in African American college women显示文摘 | Carla J Reginald J | 1998 | Journal of Multicultural Counseling and Development1998，26，1： | 1 |
| 5 | Clinical features of women with chronic lower abdominal pain and pelvic congestion显示文摘 | Beard RW Reginald PW Wadsworth J | 1985 | BrJObstet Gynaecol1985，95，2： | 1 |
| 6 | Racial Identity, African Self-consciousness,and Career Decision Making in African American College Women 显示文摘 | CARLA J REGINALD J | 1998 | Journal of Multicural Counseling and Development1998，26，1： | 1 |
| 7 | Medroxyprogesterone acetate in the treatment of pelvic pain due to venous congestion显示文摘 | Reginald PW Adams J Franks S | 1989 | Br J Obs--tet Gynecol1989，96，： | 1 |
| 8 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 9 | Racial Identity, African Self- con- sciousness, and Career Decision Making in Afiican American College Women显示文摘 | Carla J Reginald J | 1998 | Journal of Multicultural Counseling and Development1998，26，1： | 1 |
| 10 | Racial identity,African selfconsciousness,and career decision making in African American college women显示文摘 | Carla J Reginald J | 1998 | Journal of Multicultural Counseling and Development1998，26，1： | 1 |
| 11 | Algorithms for obtaining atmospheric surface-layer fluxes from scintillation measurements显示文摘 | Reginald J Hill | 1997 | Journal of Atmospheric and Oceanic Technology1997，14，： | 1 |
| 12 | Low ERCC 1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell Lung cancer 显示文摘 | Reginald V Lord N Brabender J | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 13 | Three-dimensional nonlinear seismic performance evaluation of retrofit measures for typical steel girder bridges显示文摘 | Padgett J E Reginald D | 2008 | Engineering Structures2008，30，10： | 1 |
| 14 | Racial identity,African self-consciousness,and career decision making in African American college women显示文摘 | Carla J Reginald J | 1998 | Journal of Muhicultural Counseling and Development1998，26，1： | 1 |
| 15 | Clinical features of women with chronic lower abdominal pain and pelvic congestion显示文摘 | Beard WR Reginald WP Wadsworth J | 1988 | Br J Obstet Gynaecol1988，95，2： | 1 |
| 16 | Racial identity, African self-con- sciousness, and career decision making in African Ameri- can college women 显示文摘 | Cara J Reginald J | 1998 | Journal of Multieuhural Counse- ling and Development1998，，26： | 1 |
| 17 | ERCC1 expression correlates with prdonged survival after cisplatin plus gemcitahine chemotherapy in non - small cell lung cancer显示文摘 | Reginald V Lord N Brabender J | 2007 | Ctin Cancer Res2007，8，： | 1 |
| 18 | Clinical features of womenwith chronic lower abdominal pain and pelvic congestion显示文摘 | Beard RW Reginald PW Wadsworth J | 1988 | Br JObstet Gynaecol1988，95，2： | 1 |
| 19 | Uterine size and endometrial thickness and the significance of cystic ovaries in women with pelvic pain due to congestion显示文摘 | Adams J Reginald PW Frandks S | 1990 | Br J Obstet Gvnaecol1990，97，： | 1 |
| 20 | Racial Identity, African Self-con- sciousness, and Career Decision Making in African Ameri- can College Women 显示文摘 | Carla J Reginald J | 1998 | Journal of Muhicultural Counse-ling and Development1998，26，1： | 1 |
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