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| 1 | Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity显示文摘The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no cure.Prematurity,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive impairment.In the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly vulnerable.Cell replacement therapy is often considered a viable option to replace progenitors that die due to glutamate excitotoxicity.We previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter injury.For that purpose,we used a well-established model of glutamate excitotoxic injury.Four-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain parenchyma.Energetics and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also ascertained.We found that OLPs did not survive in the excitotoxic environment when grafted alone.In contrast,when combined with TSC1,survival and integration of grafted OLPs was observed.Further,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by TSC1.The proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to N-methyl-D-aspartate.These changes were reversed in the presence of TSC1 and ubiquitination was decreased.The results obtained in this pre-clinical study indicate that the use of a combinatorial intervention including both trophic support and healthy OLPs constitutes a promising approach for long-term survival and successful graft integration.We established optimal conditioning of the host brain environment to promote long-term survival and integration of grafted OLPs into an inflamed neonate host brain.Experimental procedures were performed under the United States Public Health Service Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care Committee at(UCLA)(ARC#1992-034-61)on July 1,2010. | Megumi Hirose-Ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda Araceli Espinosa-Jeffrey | 2020 | Neural Regeneration Research2020，15，3： | 4 |
| 2 | Modelling of shallow landslides with machine learning algorithms显示文摘This paper introduces three machine learning(ML)algorithms,the‘ensemble'Random Forest(RF),the‘ensemble'Gradient Boosted Regression Tree(GBRT)and the Multi Layer Perceptron neural network(MLP)and applies them to the spatial modelling of shallow landslides near Kvam in Norway.In the development of the ML models,a total of 11 significant landslide controlling factors were selected.The controlling factors relate to the geomorphology,geology,geo-environment and anthropogenic effects:slope angle,aspect,plan curvature,profile curvature,flow accumulation,flow direction,distance to rivers,water content,saturation,rainfall and distance to roads.It is observed that slope angle was the most significant controlling factor in the ML analyses.The performance of the three ML models was evaluated quantitatively based on the Receiver Operating Characteristic(ROC)analysis.The results show that the‘ensemble'GBRT machine learning model yielded the most promising results for the spatial prediction of shallow landslides,with a 95%probability of landslide detection and 87%prediction efficiency. | Zhongqiang Liu Graham Gilbert Jose Mauricio Cepeda Asgeir Olaf Kydland Lysdahl Luca Piciullo Heidi Hefre Suzanne Lacasse | 2021 | Geoscience Frontiers2021，12，1： | 3 |
| 3 | Addition of ultralow dose naloxone to postoperative morphine PCA:unchanged analgesia and opioid requirement but decreased incidence of opioid side effects显示文摘 | Cepeda M S Alvarez H Morales 0 | 2004 | Pain2004，107，12： | 1 |
| 4 | Postcolumn excitation of aflatoxins using cyclodextrins in liquid chromatography for food analysis显示文摘 | Cepeda A Franco CM Fente CA | 1996 | J Chromatogr A1996，721，1： | 1 |
| 5 | Isolation of patients in single rooms or cohorts to reduce sp read of MRSA in intensive-care units:a respective two-centre study显示文摘 | Cepeda JA Whitehouse T Cooper B | 2005 | Lancet2005，365，： | 1 |
| 6 | Comparative study ofcellular and synaptic abnormalities in brain tissue samples frompediatric tuberous sclerosis complex and cortical dysplasia typeII显示文摘 | Cepeda C Andre VM Yamazaki I | 2010 | Epilepsia2010，51，3： | 1 |
| 7 | Some methodological points to consider when perform- ing systematic reviews in comparative effectiveness research显示文摘 | Berlin JA Cepeda MS | 2012 | Clin Trials2012，9，1： | 1 |
| 8 | Review of methods for analysis of carotenoids显示文摘 | Amorim-Carrilho KT Cepeda A Fente C | 2014 | Trac Trends in Analytical Chemistry2014，，： | 1 |
| 9 | Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive - care units : prospective two - centre study 显示文摘 | Cepeda JA Whitehouse T Cooper B | 2005 | Lancet2005，365，： | 1 |
| 10 | Dynamic Capabilities and Operational Capabilities: A Knowledge Management Perspective显示文摘 | Gabriel Cepeda Dusya Vera | 2007 | Journal of Business Research2007，60，： | 1 |
| 11 | Are cytomegalic neu-rons and balloon cells generators of epileptic activity in pediat-ric cortical dysplasia? 显示文摘 | Cepeda C Andre VM Vinters HV | 2005 | Epilepsia2005，46，5： | 1 |
| 12 | Finding a better drug for epilepsy: the mTOR pathway as an antiepilepto- genic target 显示文摘 | Galanopoulou AS Gorter JA Cepeda C | 2012 | Epilepsia2012，53，7： | 1 |
| 13 | Phosphorus fractions and dynamics in surface earthworm casts under native and improved grasslands in a Colombian savanna Oxisol显示文摘 | Jimenez J J Cepeda A Decaens T | 2003 | Soil Biology&Biochemistry2003，35，5： | 1 |
| 14 | Morphologicaland electrophysiological characterization of abnormal cell typesin pediatric cortical dysplasia显示文摘 | Cepeda C Hurst RS Flores-Hernandez J | 2003 | J Neurosci Res2003，72，4： | 1 |
| 15 | Dynamic capabilities and operational capabilities: A knowledge management perspective显示文摘 | Cepeda G and Vera D | 2007 | Journal of Business Research2007，60，5： | 1 |
| 16 | Augmentation of pulmonary epithelial cell IL-8 expression and permeability by pre-B-cell colony enhancing factor显示文摘 | Li H Liu P Cepeda J | | 0，，： | 1 |
| 17 | Changes in executive control across the life span:examination of task-switching performance 显示文摘 | Cepeda N J Kramer AF Gonzalez de Sather JC | 2001 | Dev Psychol2001，37，5： | 1 |
| 18 | Dynamic capabilities and operational capabilities: a knowledge management perspective显示文摘 | Cepeda G Vera D | 2007 | Journal of Business Research2007，60，3： | 1 |
| 19 | Music for pain relief显示文摘 | Cepeda Ms Carr DB Lau J | 2006 | Cochrane Database Syst Key2006，，00： | 1 |
| 20 | Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis 显示文摘 | Cepeda C Andre VM Levine MS | 2006 | Epilepsy Behav2006，9，2： | 1 |
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