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| 1 | Effect of single subconjunctival injection of bevacizumab on primary pterygium:clinical,histopathological and immunohistochemical study显示文摘AIM:To evaluate the effect(clinically,histopathologically and immunohistochemically) and safety of a single intrapterygium injection of bevacizumab.METHODS:Prospective interventional study comprised 40 eyes of 40 patients with primary fleshy pterygia who attended the Outpatient Clinic of Department of Ophthalmology,Assiut University Hospitals,Egypt from May 2015 to May 2016.Patients were randomly classified into 2 groups:the first group received a single intralesional injection of bevacizumab(Avastin;Genentech,San Francisco,CA,USA);the second group comprised patients who did not receive subconjunctival bevacizumab.Excision of pterygium and conjunctival auto graft was done in both groups.The excised pterygium tissues were subjected to histopathological and immunohistochemical evaluation.RESULTS:The study comprised 40 eyes of 40 patients(33 men,7 women) of age range from 31-58 y.The study group included 22 eyes.The control group included 18 eyes.A decrease in the vascularity of the pterygium was noted in all injected cases.The mean vessel count was higher in non-injected pterygia than that in injected pterygia and the difference was statistically significant(P=0.001).Also,the mean vessel count in both groups was significantly higher than normal conjunctive(P=0.005 and 0.001).A statistically significant difference in vascular endothelial growth factor(VEGF) expression between injected and non-injected cases was detected in the epithelial,stromal and endothelial cells(P=0.0001,0.016,0.014).No serious intraoperative complications occurred in both groups.CONCLUSION:The use of single intra lesional injection of Avastin in pterygium decreased vascularity and decreased VEGF expression in injected pterygium after one month.Our study proved the effect of single intra lesional injection of Avastin on pterygium.Further studies may enable limiting the need for surgery and improve quality of life for patients with pterygia. | Tarek A Mohamed Wael Soliman Ahmed M.Fathalla Abeer El Refaie | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 2 | Lycopene attenuates thermal hy- peralgesia in a diabetic mouse model of neuropathic pain显示文摘 | A1-Malki AL Moselhy SS Refai MY | 2008 | Europe- an Journal of Pain2008，12，5： | 1 |
| 3 | Apolipoprotein CⅢpromotes Ca2+ dependent beta cell death in type 1 diabetes显示文摘 | Juntti-Berggren L Refai E Appelskog I | | 0，，： | 1 |
| 4 | Addition of dexm- edetomidine to bupivaeaine for greater palatine nerve block prolongs post-operative analgesia after cleft palate repair 显示文摘 | Obayah GM Refaie A Aboushanab O | 2010 | Eur J Anaesthesiol2010，27，3： | 1 |
| 5 | Polymers for colon specific drug delivery显示文摘 | Schacht Etienne Gevaert An Kenawy El Refaie | 1996 | J Controlled Release1996，，39： | 1 |
| 6 | Living -related -donor kidney transplantation outcome in recipients with primary focal - seg mental glomerulosclerosis 显示文摘 | Refaie A Sobh M Mousfafa F | 1999 | Am J Nephrol1999，19，1： | 1 |
| 7 | Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treament显示文摘 | Mikik K Al Refaie W Xu M | 2000 | Cancer Res2000，60，10： | 1 |
| 8 | The assessment o:' neutro- phil CD64 count as an early warning marker of joint replace- ment infection显示文摘 | Perry J Reed MR Refaie R | 2013 | Arch Orthop Trauma Surg2013，133，10： | 1 |
| 9 | Hydroconversion of C5 - C8 alkanes over Zr - containing supported catalysts prepared by metal vapor method显示文摘 | Akhmedov Vagif M Al - Khowaiter Soliman H Al - Refai Jamal K | 2003 | Applied catalysis A: General2003，252，： | 1 |
| 10 | Efficacy of anterior fissureless technique for right upper lobectomies: a case-matched analysis 显示文摘 | Refai M Brunelli A Salati M | 2010 | European journal of cardiothoracic surgery:official journal of the European Association for Cardio-thoracic Surgery2010，11，3： | 1 |
| 11 | Tuberculosis in Egyptian kidney trasplant recipients:study of clinical couse and outcome显示文摘 | el-Agroudy A E Refaie A F Moussa O M Ghoneim -M-A | 2003 | J Nephrol2003，16，3： | 1 |
| 12 | Crosslinking of partially carboxymethylated cotton fabric via cationization显示文摘 | Mohamed Hashem Rakia Refaie Ali Hebeish | 2005 | Journal of Cleaner Production2005，13，： | 1 |
| 13 | Understanding visual metaphor 显示文摘 | E1 Refaie E | 2003 | Visual Communication2003，2，1： | 1 |
| 14 | The influence of dilution of topical semisolid preparations on hydrocortisone permeation through excised human stratum corneum显示文摘 | REFAI H MuLLER-GOYMANN C C | 2002 | Eur J Pharm Biopharm2002，54，2： | 1 |
| 15 | Living- related - donor kidney transplantation outcome in recipients with primary focalsegment glom Crulosclerosis显示文摘 | REFAIE A SOBH M MOUSTAFA F | 1999 | Am J Nephrol1999，19，： | 1 |
| 16 | Spontaneous isolated con vexity subarachnoid hemorrhage: presentation, radiological findings, differential diagnosis, and clinical course 显示文摘 | Refai D Botros JA Strom RG | 2008 | J Neuro- surg2008，109，6： | 1 |
| 17 | Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events显示文摘 | Ridker PM Refai N Rose L | 2002 | N Engl J Med2002，347，4： | 1 |
| 18 | Fractional-slot concentrated-windings synchronous permanent magnet machines:opportunities and challenges显示文摘 | Refaie ELAM | 2010 | IEEE Transactions onIndustrial Electronic2010，57，1： | 1 |
| 19 | Giant cell tumor of the thoracic spine: case report and review of the literature显示文摘 | Refai D Dum G Pv Santiago P | 2009 | Surg Neurol2009，71，2： | 1 |
| 20 | Detection of residual stones after percutaneous nephrolithotomy:role of nonenhanced spiral computerized tomography显示文摘 | Osman Y El-Tabey N Refai H | 2008 | J Urol2008，179，1： | 1 |
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