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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders显示文摘AIM:To explore associations between nonalcoholic fatty liver disease(NAFLD)and benign gastrointestinal and pancreato-biliary disorders.METHODS:Patient demographics,diagnoses,and hospital outcomes from the 2010 Nationwide Inpatient Sample were analyzed.Chronic liver diseases were identified using International Classification of Diseases,the 9thRevision,Clinical Modification codes.Patients with NAFLD were compared to those with other chronic liver diseases for the endpoints of total hospital charges,disease severity,and hospital mortality.Multivariable stepwise logistic regression analyses to assess for the independent association of demographic,comorbidity,and diagnosis variables with the event of NAFLD(vs other chronic liver diseases)were also performed.RESULTS:Of 7800441 discharge records,32347(0.4%)and 271049(3.5%)included diagnoses of NAFLD and other chronic liver diseases,respectively.NAFLD patients were younger(average 52.3 years vs55.3 years),more often female(58.8%vs 41.6%),less often black(9.6%vs 18.6%),and were from higher income areas(23.7%vs 17.7%)compared to counterparts with other chronic liver diseases(all P<0.0001).Diabetes mellitus(43.4%vs 28.9%),hypertension(56.9%vs 47.6%),morbid obesity(36.9%vs 8.0%),dyslipidemia(37.9%vs 15.6%),and the metabolic syndrome(28.75%vs 8.8%)were all more common among NAFLD patients(all P<0.0001).The average total hospital charge($39607 vs$51665),disease severity scores,and intra-hospital mortality(0.9%vs6.0%)were lower among NALFD patients compared to those with other chronic liver diseases(all P<0.0001).Compared with other chronic liver diseases,NAFLD was significantly associated with diverticular disorders[OR=4.26(3.89-4.67)],inflammatory bowel diseases[OR=3.64(3.10-4.28)],gallstone related diseases[OR=3.59(3.40-3.79)],and benign pancreatitis[OR=2.95(2.79-3.12)]on multivariable logistic regression(all P<0.0001)when the latter disorders were the principal diagnoses on hospital discharge.Similar relationships were observed when the latter disorders were associated diagnoses on hospital discharge.CONCLUSION:NAFLD is associated with diverticular,inflammatory bowel,gallstone,and benign pancreatitis disorders.Compared with other liver diseases,patients with NAFLD have lower hospital charges and mortality. | Srinevas K Reddy Min Zhan H Richard Alexander Samer S El-Kamary | 2013 | World Journal of Gastroenterology2013，19，45： | 4 |
| 3 | Bovine recombinant interleukin-2 augments immunity and risistance to bovine herpes virus infection显示文摘 | Reddy P G Blecha F Minocha H C | 1989 | Vet Immunol Immunopathol1989，23，： | 2 |
| 4 | Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs显示文摘AIM: To evaluate and compare the hepatoprotective and immunomodulatory effects of Curcuma longa (CL), Ocimum sanctum (OS), Tinospora cordifolia (TC) and Zizyphus mauritiana (ZM) on liver injury and immunosuppression induced by Isoniazid (INH), Rifampicin (RIF) and Pyrazinamide (PZA). METHODS: Duncan Hartley guinea pigs, weighing 700-1050 g, were treated orally with 50 mg/kg of INH, 100 mg/kg of RIF and 300 mg/Kg of PZA for 21-d. 200 mg/kg (bw) of each herb crude extract was administered to the herb control group and 2-h previous to INH + RIF + PZA (AKT) doses to the Herb + AKT groups. Serum alanine aminotransferase (ALT), aspertate aminotransferase (AST) bilirubin and Alkaline Phosphatase (ALP) were assessed on d 0 and 21 in all the groups. Phagocytic % (P%), Phagocytic Index (PI) and Chemotactic Index (CI) were also measured as immunologic parameters. Histological analysis was carried out to assess injury to the liver. RESULTS: The AKT treated control group showed hepatotoxicity as judged by elevated serum AST 5-fold, AST/ALT ratio 4-fold, ALP 2-fold and hepatological changes, such as focal necrosis, portal triaditis and steatosis. Immune function was suppressed as judged by decreased P% (51.67 ?1.68 vs 40.61 ?1.28, P < 0.01), PI (2.0725±0.05 vs 0.61±0.05, P < 0.001) and CI (1.8525±0.04 vs 0.695±0.07, P < 0.001). All four herb treated groups showed normal liver histology, enzyme levels and increased P%, while PI and CI were enhanced in the TC and ZM treated groups, respectively. CL + AKT, TC + AKT and ZM + AKT showed nearly normal histology with minimal inflammation and microvesicular steatosis, while OS + AKT showed partial protection. Hepatotoxicity was prevented by restricting the rise of AST by 2-fold in CL + AKT and TC + AKT groups and by 3-fold in OS + AKT and ZM + AKT groups, AST/ALT by 2-fold and ALP to normal levels in all four groups. All four herb + AKT groups showed normal to enhanced neutrophil function. CONCLUSION: All four herbs showed hepatoprotective potential and prevented immunosuppression. CL and TC showed the highest hepatoprotective activity, while TC and ZM showed strong immunostimulatory activity. | Meghna R Adhvaryu Narsimha Reddy Minoo H Parabia | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 5 | Human lens epithelial cell line显示文摘 | Ibaraki N Chen SC Lin LR Okamoto H Pipas JM Reddy VN | 1998 | Exp Eye Res1998，67，5： | 1 |
| 6 | Indium(llI) chloride/2-iodoxybenzoic acid: a novel reagent system for the conversion of indoles into isatins显示文摘 | Yadav JS Reddy B V S Reddy C h S | 2007 | Synthesis2007，5，： | 1 |
| 7 | Analysis of piezoelectrically actuated beams using a layer-wise displacement theory显示文摘 | Robbins D H Reddy J N | 1991 | Comput Struct1991，41，2： | 1 |
| 8 | Indentation penetration and perforation of composite laminates and sandwich panels under quasi-static and projectile loading显示文摘 | Wen H M Reddy T Y Reid S R | 1998 | Key Eng Mater1998，，1： | 1 |
| 9 | Selectivity of 4,5,6,7 -tetrabromo-benzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ( Ca-sein kinase-2')显示文摘 | Samo S Reddy H Meggio F | 2001 | FEBS Lett2001，496，1： | 1 |
| 10 | Promoting effect of bile acids in colon carcinogenensis in germ-flee and conventional F344 rats显示文摘 | Reddy B S Watanabe K Weisburger J H | | 0，，37： | 1 |
| 11 | Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression 显示文摘 | Anderson H Patch TC Reddy PN | 2015 | Blood2015，126，26： | 1 |
| 12 | Chemoprevention of colon carcinogenesis by dietary perillyl alcohol显示文摘 | Reddy B S Wang C X Samaha H | 1997 | Cancer Res1997，57，3： | 1 |
| 13 | Penetration and perforation of composite sandwich panels by hemispherical and conical projectiles显示文摘 | Reddy T Y Wen H M Reid S R | 1998 | Trans ASME J Pres Ves Tech1998，120，2： | 1 |
| 14 | Naturally occurring anticarcinogenic substances in foodstuffs显示文摘 | Fiala E S Reddy B S Weisburger J H | 1985 | Annu Rev Nutr1985，5，： | 1 |
| 15 | Phosphorus retention capacity of root bed media of sub-surface flow construeted wetlands 显示文摘 | PANT H K REDDY K R LEMON E | 2001 | Ecological Engineering2001，17，4： | 1 |
| 16 | Deformation and failure of clamped beams under low speed impact loading 显示文摘 | Wen H M Reddy T Y Reid S R | 1995 | Int J Impact Eng1995，16，3： | 1 |
| 17 | Nitrification and denitrification at the plant root and sediment interfaces in wetlands显示文摘 | Reddy K R Patrick W H Lindau C W | | 0，，： | 1 |
| 18 | Emulsion sta- bility-theoretical studies on simultaneous flocculation and creaming显示文摘 | REDDY S R MELIK D H FOGLER H S | 1981 | J Colloid Interface Sci1981，82，1： | 1 |
| 19 | Dynamin -related protein 1 and mitochondrial fragmentation in neurodegenerative dis- eases显示文摘 | REDDY P H REDDY T P MANCZAK M | 2011 | Brain Res Rev2011，67，12： | 1 |
| 20 | Nano Li Mn2O4with spherical morphology synthesized by a molten salt method as cathodes for lithium ion batteries显示文摘 | Zhao X Reddy M V Liu H X | 2012 | Rsc Advances2012，2，19： | 1 |
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