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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Herbal supplement sales experience slight increase in 2008 显示文摘 | Cavaliere C Rea P Lynch ME | 2009 | Herbal Gram2009，82，： | 1 |
| 4 | Scribing of thin sapphire substrates with a 266nm Q- switched solid-state laser 显示文摘 | REA E C Jr | 2004 | Proceedings of the SPIE2004，5339，： | 1 |
| 5 | Herbal supplement sales rise in all channels in 2009 显示文摘 | Cavaliere C Rea P Lynch M E | 2010 | HerbalGram2010，86，2： | 1 |
| 6 | Pesticide sorption onto aquifer sediments 显示文摘 | Rea J E Cooper C S Parker A | 1998 | J of Geochemical Exploration1998，64，： | 1 |
| 7 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 8 | Adjuvant tamoxifen and ex- emcstane in early breast cancer (TEAM) : a randomised phase 3 trial 显示文摘 | Van De Velde C J Rea D Seynaeve C et at | 2011 | Lancet2011，377，9762： | 1 |
| 9 | Physiological response of 'Larry Ann' plums to cold storage and 1-MCP treatment显示文摘 | Larrigaudi~rea C Candanb AP Ubacha D | 2009 | Postharvest Biology and Technology2009，51，1： | 1 |
| 10 | The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis显示文摘 | Tunwell REA Wickenden C Bertrand BMA | 1996 | Biochem J1996，318，： | 1 |
| 11 | CPR with Chest Compression Alone or with Rescue Breathing 显示文摘 | Rea TD Fahrenbruch C Culley L | 2010 | N Engl J Med2010，363，5： | 1 |
| 12 | On-line combus- tion monitoring on dry low NO industrial gas tur bines显示文摘 | REA S JAMES S GOY C | 2003 | Measurement Science and Technology2003，14，7： | 1 |
| 13 | Efficacy of Immobilized Polyplexes and Lipoplexes fi-r Substrate-Mediated Gene Delivery 显示文摘 | Bengali Z Rea J C Gihly R F | 2009 | Biotechnol Bioeng2009，102，6： | 1 |
| 14 | Neodymium isotopic variation in North Pacific modern silicate sediment and the insignificance of detrital REE contributions to seawater显示文摘 | Jones C E Halliday A N Rea D K | 1994 | Earth and Planetary Science Letters1994，127，： | 1 |
| 15 | Herbal supplement sales rise in all channels in 2009 显示文摘 | Cavaliere C Rea P Lynch M E | 2010 | Herbal Gram2010，86，2： | 1 |
| 16 | Adjuvant tamoxifen and exemestane in early breast cancer (TEAM):A randomised phase 3 trial显示文摘 | van de Velde CJH Rea D Seynaeve C | 2011 | Lancet2011，377，： | 1 |
| 17 | Timing and sequence of the onset of overweight, dieting, and binge eating in overweight patients with binge eating disorder 显示文摘 | REAS D L GRILO C M | 2007 | Int J Eat Disord2007，40，2： | 1 |
| 18 | Results of enblock resection inpatients affected by primary lung cancer with chest wall invasion显示文摘 | Rea F Breda C Guanella G | 2003 | Lung Cancer2003，41，2： | 1 |
| 19 | CPR with chest compres- sion alone or with rescue breathing 显示文摘 | Rea TD Fahrenbruch C Culley L | 2010 | N Engl J Med2010，363，5： | 1 |
| 20 | Lung transplantation for lymphangioleiomyomatosis : the European experience 显示文摘 | Benden C Rea F Behr J | 2009 | J Heart Ltmg Transplant2009，28，1： | 1 |
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