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| 1 | ConservativeapproachinPeutz-JeghersSyndrome:Single-balloon enteroscopyandsmallbowelpolypectomy显示文摘AIM: To assess the usefulness of the balloon assisted enteroscopy in preventing surgical intervention in pa-tients with Peutz-Jeghers syndrome (PJS) having a small bowel large polyps. METHODS: Seven consecutive asymptomatic pts(age 15-38 years) with PJS have been collected; six under-went polypectomy using single balloon enteroscopy(Olympus SIF Q180) with antegrade approach using push and pull technique. SBE system consists of the SIF-Q180 enteroscope, an overtube balloon control unit(OBCU Olympus Balloon Control Unit) and a dispos-able silicone splinting tube with balloon(ST-SB1). All procedures were performed under general anesthesia. Previously all pts received wireless capsule endos-copy(WCE). Prophylactic polypectomy was reservedmainly in pts who had polyps > 15 mm in diameter. The balloon is inflated and deflated by a balloon control unit with a safety pressure setting range from-6.0 kPa to +5.4 kPa. Informed consent has been obtained from pts or parents for each procedure.RESULTS: Six pts underwent polypectomy of small bowel polyps; in 5 pts a large polyp > 15 mm(range 20-50 mm in diameter) was resected; in 1 patient with WCE negative, SBE was performed for previous surgi-cal resection of gastrointestinal stromal tumors. In 2 pts endoscopic clips were placed due to a polypectomy. No surgical complication have been reported. SBE with resection of small bowel large polyps in PJS pts was useful to avoid gastrointestinal bleeding and emergency laparotomy due to intestinal intussuscep-tions. No gastrointestinal tumors were found in sub-sequent enteroscopic surveillance in all seven pts. In order surveillance, all pts received WCE, upper en-doscopy, ileocolonoscopy every 2 years. No pts had extraintestinal malignant lesions. SBE was performed when WCE was positive for significant polyps(> 15 mm).CONCLUSION: The effective of prophylactic polyp-ectomy of small bowel large polyps(> 15 mm) could be the first line treatment for conservative approach in management of PJS patients. | Torroni F Romeo E Rea F De Angelis P Foschia F Faraci S Federici di Abriola G Contini AC Caldaro T Dall’Oglio L | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，3，： | 3 |
| 4 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 5 | 初始降压治疗策略与治疗惰性:基于人群的大型队列研究证据显示文摘尽管由于治疗惰性导致血压控制不佳,但许多高血压患者的治疗并未升级。在实际诊疗中,这种现象有多普遍还没有具体的数据。研究者纳入来自Lombardy地区(意大利)开始降压治疗采用1种(100982例)或2种药物固定剂量或自由联合(24653例)的患者125635例(年龄40~85岁)。采用对数二项式回归模型评估联合治疗所占比例与初始治疗策略的关系。 | 赵狄 练桂丽 Rea F Corrao G Merlino L Mancia G | 2018 | 中华高血压杂志2018，26，10： | 2 |
| 6 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift and cooling of the Northern Hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，： | 1 |
| 7 | Desmopressin and oxybutynin in monosymptomatie nocturnal enuresis : a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors 显示文摘 | Montaldo P Tafuro L Rea M | 2012 | BJU Int2012，110，8： | 1 |
| 8 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，3： | 1 |
| 9 | Experience with the 'da Vinci' robotic system for thymectomy in patients with myasthenia gravis:report of 33 cases显示文摘 | Rea F Marulli G Bortolotti L | 2006 | Ann Thorac Surg2006，81，2： | 1 |
| 10 | Industrial experiments on pulse simultaneous removal of NOx and SO2, from flue gas显示文摘 | Dinelli G Civitano L Rea M | 1990 | IEEE Trans1990，25，1： | 1 |
| 11 | Response of bushbean exposed to acid rain mist显示文摘 | Hindawi I J Rea J A Griffis W L | 1980 | American Journalof Botany1980，67，2： | 1 |
| 12 | Late Cenozoic eolian deposition in the North Pacific: Asia drying, Tibetan uplift and cooling of the Northern Hemisphere显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，： | 1 |
| 13 | CPR with Chest Compression Alone or with Rescue Breathing 显示文摘 | Rea TD Fahrenbruch C Culley L | 2010 | N Engl J Med2010，363，5： | 1 |
| 14 | The VMP1-Beelin 1 inter- action regulates autophagy induetion显示文摘 | Molejon MI Ropoloa ReA L | 2013 | Sei Rep2013，3，： | 1 |
| 15 | Long electron-hole separation of ZnO-CdS core-shell quantum dots 显示文摘 | XU F VOLKOV V ZHU Y BAI H Y REA A VALAPPIL N V SU W GAO X Y KUSKOVSKY I L MATSUI H | 2009 | Journal of Physical Chemistry C2009，113，19： | 1 |
| 16 | Industrial experiments on pulse simultaneous removal of NOx and SOx from flue gas显示文摘 | Dinelli G Civitano L Rea M | 1990 | IEEE Trans Ind Appl1990，26，3： | 1 |
| 17 | Timing and sequence of the onset of overweight, dieting, and binge eating in overweight patients with binge eating disorder 显示文摘 | REAS D L GRILO C M | 2007 | Int J Eat Disord2007，40，2： | 1 |
| 18 | The clinical utility of long term humidification therapy in chronic airway disease 显示文摘 | Rea H McAuley S Jayaram L | 2010 | Respir Med2010，104，4： | 1 |
| 19 | Lensless light focusing with the centric marine diatom Coscinodiscus walesii显示文摘 | DE STEFANO L REA I RENDINA I | 2007 | Optics Express2007，15，18： | 1 |
| 20 | Industrial experiments on pulse corona simuhaneous removal of NOx and SO2 from flue gas 显示文摘 | Dinelli G Civitano L Rea M | 1990 | IEEE Transaction on Industry Application1990，26，3： | 1 |
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