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| 1 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 2 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 3 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 4 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 5 | Immunomagnetic cell enrichment detects more disseminated cancer cells than immunocytochemistry in vitro显示文摘 | Zigeuner RE Riesenberg R Pohla H | 2000 | J Urol2000，164，： | 2 |
| 6 | Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice显示文摘 | Christophe Combadière Stéphane Potteaux Mathieu Rodero Tabassome Simon Adeline Pezard Bruno Esposito Régine Merval Amanda Proudfoot Alain Tedgui Ziad Mallat | 2008 | Circulation2008，，13： | 2 |
| 7 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 8 | Outcome and reproduction function after conservative surgery for bordline ovarian tumors 显示文摘 | Leek R Scully RE | 2000 | Am J Surg Pathol2000，24，11： | 1 |
| 9 | Effect of cetyhrimethyl ammonium bromide (CTAB) in determination of dopamine and ascorbic acid using carbon paste electrode modified with tin hexacyanoferrate显示文摘 | Hosseinzadeh R Sabzi RE Ghasemlu K | 2009 | Colloid Surface B Biointegraces2009，68，2： | 1 |
| 10 | Laulimalides:new potent cytotoxic rnacrolides from a marine sponge and a nudibranch predator 显示文摘 | Corley DC Herb R Moore RE | 1988 | J Org Chem1988，53，： | 1 |
| 11 | and stereospecific align-characteristic of P53 DNA-binding consensus sequence homologies显示文摘 | COOK JL RE R Distance constraintsment requirements GIARDINA JF | 1995 | Oncogene1995，11，4： | 1 |
| 12 | Left ventricular contractility is impaired following myocardial infarction in the pig and rat:assessment by the end systolic pressure-volume relation using a singlebeat estimation technique and cine magnetic resonance显示文摘 | Setser R Henson RE Allen JS | 2000 | Imaging Ann Biomed Eng2000，28，5： | 1 |
| 13 | Isolation of circulating cancer cells from whole blood by immunomagnetic cell enrichment and unenriched immunocytochemistry in vitro 显示文摘 | Zigeuner RE Riesenberg R Pohla H | 2003 | J Urol2003，169，2： | 1 |
| 14 | En- terovirus infections of the central nervous system 显示文摘 | Rhoades RE Tabor-Godwin JM Tsueng G Feuer R | 2011 | Virol- ogy2011，411，2： | 1 |
| 15 | Antioxidant ac- tivity applying an improved ABTS radical cation decolorization assay显示文摘 | RE R PELLEGRINI N PROTEGGENTE A | 1999 | Free Radical Biology and Medicine1999，26，910： | 1 |
| 16 | The ileal neo- bladder:complications and functional results in 363 patients af- ter 11 years of followup显示文摘 | Hautmann RE de Petriconi R Gottfried HW | 1999 | J Urol1999，161，2： | 1 |
| 17 | Antioxidant activity ap- plying an improved ABTS radical cation decolorization assay 显示文摘 | RE R PELI_EGRINI N PROTEGGENTE A | 1999 | FreeRadical Biology and Medicine1999，26，910： | 1 |
| 18 | Characterization of ‘safe sites’ for pioneers in primary succession on recently deglaciated terrain 显示文摘 | Jumpponen A V?re H Mattson KG Ohtonen R Trappe JM | 1999 | J Ecol1999，87，1： | 1 |
| 19 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 20 | Productivity growth,technical progress,and efficiency change in industrialized countries显示文摘 | F?re R Grosskopf S Norris M | 1994 | The American Economic Review1994，，1： | 1 |
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