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| 1 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 2 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption polyelectrolyte coating method显示文摘 | Liu Q Rauth A M Wu X Y | 2007 | International Journal of Pharmaceutics2007，339，2： | 1 |
| 3 | Fatigue behavior of oblique nozzles on cylindrical shells submitted to internal pres-sure and axial forces显示文摘 | Wei(3 E Rauth M Rudolph J | 1998 | International Journal of Pressure Vessels and Piping1998，75，6： | 1 |
| 4 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsoiptionpolyelectrolyte coating method显示文摘 | Liu Q Rauth A M Wu X Y | 2007 | International Journal of Pharmaceutics2007，339，12： | 1 |
| 5 | A NovelAmine-Dioxime Chelator for Technetium-99m:Syn-thesis and Evaluation of 2-Nitroimidazole-ContainingAnalogues as Markers for Hypoxic Cells显示文摘 | Su Z F Ballinger J R Rauth A M | 2000 | Bio-conjug Chem2000，11，5： | 1 |
| 6 | In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin 显示文摘 | CHEUNG R Y RAUTH A M RONALDSON P T | 2006 | European Journal of Pharmaceutics and Biophamaceuties2006，62，： | 1 |
| 7 | Birreductive therapies: an overview of drugs and their mechanisms of action显示文摘 | Rauth A M Melo T Misra V | 1998 | Int J Radiat Oncol Biol Phys1998，42，4： | 1 |
| 8 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectrolyte coating method显示文摘 | Liu Q Rauth A M Wu X Y | 2007 | International Journal of Pharmaceutics2007，339，： | 1 |
| 9 | Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro显示文摘 | Misra V Klamut H J Rauth A M | 2002 | Cancer Gene Ther2002，9，2： | 1 |
| 10 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectrolyte coating method 显示文摘 | Liu Q Rauth A M Wu X Y | 2007 | International Journal of Pharmaceutics2007，339，： | 1 |
| 11 | Biodegradable dextran-based microspheres for delivery of anticancer drug mitomycin C显示文摘 | Cheung R Y Ying Y Rauth A M | 2005 | Biomaterials2005，26，26： | 1 |
| 12 | A model intercomparison study of climate change-signals in extratropical circulation 显示文摘 | Rauthe M Hense A Paeth H | 2004 | Int J Climatol2004，24，： | 1 |
| 13 | Chemotherapy with a nticancer drugs encapsulated in solid lipid nanoparticles 显示文摘 | Wong H L Bendayan R Rauth A M | 2007 | Adv Drug Deliver Rev2007，59，6： | 1 |
| 14 | Characterization of a microsphere formulation containing glucose oxidase and its in vivo efficacy in a murine solid tumor model显示文摘 | Liu Q Rauth A M Liu J | 2009 | Pharm Res2009，26，10： | 1 |
| 15 | A mechanistic study of enhanced doxorubicin uptake and re- tention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system显示文摘 | WONG H L BENDAYAN R RAUTH A M | 2006 | The Journal of Pharmacology and Experimental Therapeutics2006，317，： | 1 |
| 16 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectro-]yte coating method显示文摘 | Liu Q Rauth A M Wu X Y | 2007 | International Journal of Pharmaceutics2007，339，12： | 1 |
| 17 | A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymerlipid hybrid nanoparticle system 显示文摘 | Wong H L Bendayan R Rauth A M | 2006 | J Pharmacol Exp Ther2006，317，3： | 1 |
| 18 | A New Polymer-Lipid Hybrid Nanoparticle System Increases Cytotoxicity of Doxorubiein against Multidrug-Resistant Human Breast Cancer Cells显示文摘 | Wong H L Rauth A M Bendayan R | 2006 | Pharm Res2006，23，7： | 1 |
| 19 | Development of solid lipid nanoparticles containing ionically complexed chemotherapeutic drugs and chemosensitizers 显示文摘 | Wong H L Bengavan R Rauth A M | 2004 | J Pharm Sci2004，93，： | 1 |
| 20 | Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-intemal gelation-adsorption-polyelectiolyte coating method 显示文摘 | LIU Q RAUTH A M WU X Y | 2007 | International Journal of Pharmaceutics2007，339，12： | 1 |
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