|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The therapeutic implications of immunosuppressive tumor aerobic glycolysis显示文摘In 2011,Hanahan and Weinberg added“Deregulating Cellular Energetics”and“Avoiding Immune Destruction”to the six previous hallmarks of cancer.Since this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather interdependent.The following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and progression.The mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and metabolites.From this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer metabolism.These types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity. | Bradley I.Reinfeld WKimryn Rathmell Tae Kon Kim Jeffrey C.Rathmell | 2022 | Cellular & Molecular Immunology2022，19，1： | 3 |
| 2 | New roles for pyruvate kinase M2: working out the Warburg effect显示文摘 | Emily C. Ferguson Jeffrey C. Rathmell | 2008 | Trends in Biochemical Sciences2008，，8： | 2 |
| 3 | CD95 (Fas)-dependen elimination of self-reactive B cells upon interaction with CD4+T cells 显示文摘 | Rathmell JC Cooke M P Ho W Y et aI | 1995 | Nature1995，376，6536： | 1 |
| 4 | CD95 (Fas)-dependent elimination of self-relative B cells,upon interaction with CD4+ T cells显示文摘 | Cooke MP Ho WY | 1995 | Nature1995，376，： | 1 |
| 5 | Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glutl activity and trafficking显示文摘 | Wieman HL Wofford JA Rathmell JC | 2007 | Mol Biol Cell2007，18，4： | 1 |
| 6 | VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment显示文摘 | Rathmell W K Chen S | 2008 | Expert Rev Antieaneer Ther2008，8，1： | 1 |
| 7 | The molecular biologyof renal cell carcinoma显示文摘 | Keefe SM Nathanson KL Rathmell WK | 2013 | Semin Oncol2013，40，4： | 1 |
| 8 | High-dose-intensity MVAC for Advanced Renal Medullary Carcinoma:Report of Three Cases and Literature Review显示文摘 | Rathmell WK Monk JP | | 0，，03： | 1 |
| 9 | Basic research inkidney cancer显示文摘 | Oosterwijk E Rathmell WK Junker K | 2011 | Eur Urol2011，60，4： | 1 |
| 10 | Growth factors can influence cell growth and survival through effects on glucose metabolism显示文摘 | Vander Heiden MG Plas DR Rathmell JC | 2001 | Mol Cell Biol2001，21，17： | 1 |
| 11 | Phase Ⅱ trial of sorafenib plus interferon alfa-2b as firstor second- line therapy in patients with metastatic renal cell cancer 显示文摘 | Jared A Gollob W Kimryn Rathmell W | 2007 | J Clin Oncol2007，25，22： | 1 |
| 12 | Pathways of apoptosis in lymphocyte development, homeostasis, and disease 显示文摘 | Rathmell JC Thompson CB | | Cell0，109，： | 1 |
| 13 | The central effectors of cell death in the iMMune system显示文摘 | Rathmell JC Thompson CB | 1999 | Annu Rev IMMunol1999，17，： | 1 |
| 14 | High-dose-intensity MVAC for Advanced Renal Medullary Carcinoma: Report of Three Cases and Literature Review 显示文摘 | Rathmell W K Monk J P | 2008 | Urology2008，72，3： | 1 |
| 15 | The growth mechanism of copper nanowires and their properties in flexible, transparent conducting films显示文摘 | RATHMELL A R BERGIN S M HUA Y L | 2010 | Adv Mater2010，22，： | 1 |
| 16 | Molecularly targeted therapy in renal cell carcinoma显示文摘 | Rathmell WK Wright TM Rini BI | 2005 | Expert Rev Anticancer Ther2005，5，6： | 1 |
| 17 | What is meant by service? 显示文摘 | Rathmell J M | 1966 | Journal of Mar- keting1966，30，： | 1 |
| 18 | Molecularly targeted therapy in renal cell carcinoma显示文摘 | Rathmell WK Wright TM Rini BI | 2005 | Expert Rev Anticancer Ther2005，5，6： | 1 |
| 19 | Renal cell carcinoma显示文摘 | Jonasch E Gao J Rathmell W K | 2014 | BMJ2014，10，： | 1 |
| 20 | Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis显示文摘 | Rathmell JC Lindsten T Zong WX | 2002 | Nat Immunol2002，3，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员