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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | A brief review on oral film technology 显示文摘 | Rathi V Senthil V Kammili L | 2011 | Int J Res Ayurv Pharm2011，2，4： | 1 |
| 3 | Allocating resources to support a multicommodity flow with time windows显示文摘 | Rathi A K Solanki R S Church R L | 1993 | Logistics and Transportation Review1993，28，1： | 1 |
| 4 | A finite element analysis of the convected acoustic wave motion in dissipative silencers 显示文摘 | Peat K S Rathi K L | 1995 | Journal of Sound and Vibration1995，184，3： | 1 |
| 5 | Pharmacophore identification and 3D-QSAR studies in N-(2-benzoyl phenyl)- L-tyrosines as PPAR agonists显示文摘 | Rathi L Kashaw S K Dixit A | 2004 | Bioorg Med Chem2004，12，1： | 1 |
| 6 | Allocating resources to support a multicommodity flow with time window显示文摘 | RATHI A K CHURCH R L SOLANKI R S | 1992 | Logistics and Transportation Review1992，28，： | 1 |
| 7 | Topical corticosteroid-induced rosacea-like dermatitis:a clinical study of 110 cases显示文摘 | Rathi S K Kumrah L | 2011 | Indian J Dermatol Venereol Leprol2011，77，1： | 1 |
| 8 | Allocating Resources to Support a Multi - Commodity Flow with Time Windows 显示文摘 | Rathi A K R L ChurCh R S Solanki | 1993 | Logistics and Transportation Review1993，28，： | 1 |
| 9 | Suppression of spermatogenesis before grafting increases survival and supports resurgence of spermatogenesis in adult mouse testis显示文摘 | Arregui L Rathi R Modelski M | 2012 | Fertil Steril2012，97，6： | 1 |
| 10 | Allocating resources to support a multicommodity flow with time windows显示文摘 | Rathi A K Church R L Solanki R S | 1993 | Logistics and Transportation Review1993，28，： | 1 |
| 11 | A finite element analysis of the convected acoustic wave motion in dissipative silencers 显示文摘 | Peat K S Rathi K L | 1995 | Journal of Sound and Vibration1995，184，： | 1 |
| 12 | A finite element analysis of the convected acoustic wave motion in dissipative silencers显示文摘 | Peat K S Rathi K L | 1995 | Journal of Sound and Vibration1995，184，3： | 1 |
| 13 | A finite element analysis of the convected acoustic wave motion in dissipative silencers显示文摘 | Peat K S Rathi K L | 1995 | Journal of Sound and Vibration1995，184，3： | 1 |
| 14 | Mycophenolate mofetil or standard therapy for membranous nephropathy and focal segmental glomerulosclerosis: a pilot study显示文摘 | Senthil Nayagam L Ganguli A Rathi M | 2008 | Nephrol Dial Transplant2008，23，6： | 1 |
| 15 | Topical corticosteroid-induced rosacea-like dermatitis:a clinical study of 110 cases显示文摘 | Rathi SK Kumrah L | 2011 | Indian J Dermatol Venereol Leprol2011，77，1： | 1 |
| 16 | Mycophenolate mofetil or standard therapy for membranous nephropathy and focal segmental glomernlosclerosis: a pilot study显示文摘 | Senthil Nayagam L Ganguli A Rathi M | 2008 | Nephrology Dialysis Transplantation2008，23，6： | 1 |
| 17 | Allocating resources to support a multicommodity flow with time windows 显示文摘 | Rathi A K Church R L Solanki R S | 1993 | Logistics and Transportation Review1993，28，1： | 1 |
| 18 | Allocating resource to support a multi-commodity flow with time windows 显示文摘 | Rathi A K Church R L Solanki R S | 1992 | Logis- tics and Transportation Review1992，，28： | 1 |
| 19 | Allocating resources to support a multi commodity flow with time windows 显示文摘 | Rathi A K Church R L Solanki R S | 1993 | Logistics and Transportation Review1993，28，： | 1 |
| 20 | Xenografting of sheep testis tissue and isolated cells as a model for preservation of genetic material from endangered ungulates显示文摘 | ARREGUI L RATHI R MEGEE S O | 2008 | Reproduction2008，136，1： | 1 |
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